Building Brazil’s National Action Plan: lessons learned and opportunities

Brazil’s National Action Plan on Women, Peace and Security (NAP) was launched on 8 March 2017 – International Women’s Day – in the midst of a major political crisis that affected the content of the Plan and engagement of key institutions such as the Ministry of Justice (MoJ) and the Secretariat for Women’s Policies (SPM, from Portuguese). Still, active engagement by the military and foreign service and compromises between stakeholders enabled the development of the Plan. While a strong emphasis on Brazil’s international undertakings was upheld, the domestic challenges confronted by Brazilian women living in extremely unsafe areas of the country were left out, as were other central issues, including trafficking of women, the impact of armed violence and organised crime. Towards the end of the process, civil society participation and the inclusion of a monitoring and evaluation system were undermined by the rise of a conservative tone within ministries participating in the ministerial working group tasked with the responsibility of drafting the NAP

A Compton reflection dominated spectrum in a peculiar accreting neutron star

We report on a puzzling event occurred during a long BeppoSAX observation of the slow-rotating binary pulsar GX 1+4. During this event, lasting about 1 day, the source X-ray flux was over a factor 10 lower than normal. The low-energy pulsations disappeared while at higher energies they were shifted in phase. The spectrum taken outside this low-intensity event was well fitted by an absorbed cut-off power law, and exhibited a broad iron line at ~6.5 keV probably due to the blending of the neutral (6.4 keV) and ionised (6.7 keV) K_alpha iron lines. The spectrum during the event was Compton reflection dominated and it showed two narrow iron lines at ~6.4 keV and ~7.0 keV, the latter never revealed before in this source. We also present a possible model for this event in which a variation of the accretion rate thickens a torus-like accretion disc which hides for a while the direct neutron star emission from our line of sight. In this scenario the Compton reflected emission observed during the event is well explained in terms of emission reflected by the side of the torus facing our line of sight.Comment: 10 pages; to be published in MNRA

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Characterization of Indoor Air Quality in the Cities of São Paulo and Rio de Janeiro, Brazil

Levels of several gas- and particle-phase substances present in indoor air in nonindustrial office workplaces and in restaurants was acquired during the Southeastern Brazil lndoor Air Quality Study (SEBIAQS) carried out in the summer of 1993. Simultaneous indoor and outdoor samples collected in 12 sites in the cities of São Paulo and Rio de Janeiro and in a rural area were analyzed for inhalable particulate matter (IPM dp < 15 µm), inhalable volatilizable particulate organic carbon, black (soot) carbon, trace metals, UV-RSP (d_(50) < 3.5 µm) as a marker for environmental tobacco smoke (ETS), formaldehyde, acetaldehyde, carbon monoxide, and nicotine. Indoor levels were generally higher. Alcohol-fueled vehicle emissions contributed to indoor acetaldehyde. The major sources of trace elements indoors and outdoors were respectively soil dust and combustion, resuspension, and vehicles. Dry deposition indoors was observed for S (mainly sulfate), AI, Fe, and Mn

Characterization of Indoor Air Quality in the Cities of São Paulo and Rio de Janeiro, Brazil

Levels of several gas- and particle-phase substances present in indoor air in nonindustrial office workplaces and in restaurants was acquired during the Southeastern Brazil lndoor Air Quality Study (SEBIAQS) carried out in the summer of 1993. Simultaneous indoor and outdoor samples collected in 12 sites in the cities of São Paulo and Rio de Janeiro and in a rural area were analyzed for inhalable particulate matter (IPM dp < 15 µm), inhalable volatilizable particulate organic carbon, black (soot) carbon, trace metals, UV-RSP (d_(50) < 3.5 µm) as a marker for environmental tobacco smoke (ETS), formaldehyde, acetaldehyde, carbon monoxide, and nicotine. Indoor levels were generally higher. Alcohol-fueled vehicle emissions contributed to indoor acetaldehyde. The major sources of trace elements indoors and outdoors were respectively soil dust and combustion, resuspension, and vehicles. Dry deposition indoors was observed for S (mainly sulfate), AI, Fe, and Mn

PROFILE OF PATIENTS WITH OSTEOPOROTIC FRACTURES AT A TERTIARY ORTHOPEDIC TRAUMA CENTER

<div><p>ABSTRACT Objective: To evaluate the profile of patients with osteoporotic fractures treated at a tertiary orthopedic hospital. Methods: Using questionnaires, 70 patients with osteoporotic fractures (OF) were compared with 50 outpatients with multiple osteoarthritis (OA) followed through an outpatient clinic. Results: The OF group was older (p <0.001), less heavy (p=0.003), had lower BMI (p=0.006), was more likely to be white (p=0.011), was less likely to be married (p=0.008), and had previous falls, previous fractures, old fractures (>1 year), falls in the last 12 months, fractures due to falls, and needed more assistance (p<0.05). They also had lower Lawton & Brody Instrumental Activities of Daily Living scores (p <0.05) and reported less lower limb disability, foot pathology, muscle weakness, hypothyroidism, and vitamin D intake than patients in the OA group. White race, previous falls, and previous fractures increase the risk of osteoporotic fractures by 10.5, 11.4, and 4.1 times, respectively. The chance of fracture dropped 29% for each one-unit increase in Lawton & Brody IADL score. Married participants had fewer fractures than participants with other marital status. Conclusion: Together, race, marital status, previous falls, foot pathologies, previous fractures, and IADL scores define the profile of patients with osteoporotic fractures. Level of Evidence III; Case control study.</p></div

Densitometria clínica: posições oficiais 2006 Clinical densitometry: official positions 2006

Descrevemos as posições oficiais da Sociedade Brasileira de Densitometria Clínica (SBDens) para a realização e o relato do exame de densitometria óssea. Essas posições foram obtidas por consenso em encontro realizado em São Paulo no ano de 2006. A SBDens contou com o apoio de várias sociedades científicas descritas no texto.<br>We describe the official positions of the Brazilian Society for Clinical Densitometry (SBDens) for the performance and report of the bone mineral density testing. These positions were obtained by consensus in a meeting at São Paulo in 2006. SBDens positions were supported by other scientific societies described in the text

Particle emission from heavy-duty engine fuelled with blended diesel and biodiesel

In this study, particulate matter (PM) were characterized from a place impacted by heavy-duty vehicles (Bus Station) fuelled with diesel/biodiesel fuel blend (B3) in the city of Londrina, Brazil. Sixteen priority polycyclic aromatic hydrocarbons (PAH) concentrations were analyzed in the samples by their association with atmospheric PM, mass size distributions and major ions (fluorite, chloride, bromide, nitrate, phosphate, sulfate, nitrite, oxalate; fumarate, formate, succinate and acetate; lithium, sodium, potassium, magnesium, calcium and ammonium). Results indicate that major ions represented 21.2% particulate matter mass. Nitrate, sulfate, and ammonium, respectively, presented the highest concentration levels, indicating that biodiesel may also be a significant source for these ions, especially nitrate. Dibenzo[a,h]anthracene and indeno[1,2,3,-cd]pyrene were the main PAH found, and a higher fraction of PAH particles was found in diameters lower than 0.25 mu m in Londrina bus station. The fine and ultrafine particles were dominant among the PM evaluated, suggesting that biodiesel decreases the total PAH emission. However, it does also increase the fraction of fine and ultrafine particles when compared to diesel.National Institute of Science and Technology for Energy and Environment (INCTEA)National Institute of Science and Technology for Energy and Environment (INCT-EA) [15/2008