Facial anthropometry in an adult male with Sotos syndrome

Introduction: Sotos Syndrome is a dominant autossomic disease caused by a mutation in NSD1 gene localized in chromosome 5. The craniofacial phenotype of Sotos Syndrome is quite distinctive, especially in the young child, and includes macrocephaly, widelyspaced eyes, prominent chin and mandible, high and curved forehead, palpebral slits oblique and downward, long and narrowface. This phenotype plays an important role in the identification of this syndrome. Objective: The aim of this study was to analyze the craniofacial anthropometric landmarks of a young adult male with medical diagnosis of Sotos Syndrome. Material and methods: Using noninvasive method of craniofacial anthropometry, twenty five anthropometric measurements were taken of the individual and compared with the facial pattern of non-syndromic individuals,matched in gender and age. The findings were standards and converted to Z-scores. Results: the data analysis showed that the majority of variables were in supernormal range (greater than +2 standard deviation (SD). None none of them was in the subnormal range (less than –2SD). Conclusion: Anthropometric analysis of Sotos Syndrome demonstrated the usefulness of craniofacial analysisin defining abnormal craniofacial dimensions.Introduction: Sotos Syndrome is a dominant autossomic disease caused by a mutation in NSD1 gene localized in chromosome 5. The craniofacial phenotype of Sotos Syndrome is quite distinctive, especially in the young child, and includes macrocephaly, widelyspaced eyes, prominent chin and mandible, high and curved forehead, palpebral slits oblique and downward, long and narrowface. This phenotype plays an important role in the identification of this syndrome. Objective: The aim of this study was to analyze the craniofacial anthropometric landmarks of a young adult male with medical diagnosis of Sotos Syndrome. Material and methods: Using noninvasive method of craniofacial anthropometry, twenty five anthropometric measurements were taken of the individual and compared with the facial pattern of non-syndromic individuals,matched in gender and age. The findings were standards and converted to Z-scores. Results: the data analysis showed that the majority of variables were in supernormal range (greater than +2 standard deviation (SD). None none of them was in the subnormal range (less than –2SD). Conclusion: Anthropometric analysis of Sotos Syndrome demonstrated the usefulness of craniofacial analysisin defining abnormal craniofacial dimensions

APLICABILIDADE DE TEORIA DE ENFERMAGEM PARA INTERVENÇÃO PRÁXICA NA ATENÇÃO PRIMÁRIA À SAÚDE: REVISÃO INTEGRATIVA

Objetivo: analisar as evidências científicas acerca do uso da Teoria de Intervenção Práxica da Enfermagem em Saúde Coletiva na atenção primária à saúde por meio de estudos de fontes primárias. Método: trata-se de uma revisão integrativa, sem delimitação de tempo e idiomas, com pesquisas nas bases de dados LILACS, MEDLINE/PubMED, CINAHL, SCOPUS, EMBASE e Web of Science e na biblioteca eletrônica SciELO. Resultados: foram incluídos 15 artigos, que se restringiram às fases de captação (nas dimensões estrutural, particular e singular) e interpretação da realidade objetiva, o que evidenciou uma lacuna de conhecimentos quanto à efetividade da teoria em relação à intervenção na realidade objetiva. Considerações finais: a análise das evidências científicas ratificou, apesar da utilização discreta e pontual da Teoria de Intervenção Práxica da Enfermagem em Saúde Coletiva, o seu potencial para o direcionamento das práticas dos enfermeiros na atenção primária à saúde

Prevalência do uso de tabaco e sua relação com a autopercepção de depressão: uma análise de dados secundários

Considerando as consequências intrínsecas dos sintomas depressivos ao bem-estar e a relação de possível causalidade e agravamento entre depressão e uso de tabaco, o objetivo geral do presente estudo foi verificar as características pessoais e de saúde dos tabagistas, analisando a prevalência global do uso de produtos derivados do tabaco e sua correlação com as alterações de humor, especificamente, com a autopercepção de depressão por meio de dados secundários. Para tal, foi realizado um estudo transversal, quantitativo e descritivo durante o mês de Agosto e Setembro de 2023, com dados secundários disponíveis no DATASUS. Para análise dos dados utilizou-se de um tratamento descritivo e inferencial das variáveis, compreendendo um nível de significância de p<0,05. Em 2013, cerca de 14,7% da população brasileira eram fumantes, com uma prevalência maior naqueles de 18 a 59 anos (14,3%) e no sexo masculino (18,87%). Quanto aos problemas de depressão, 21,48% dos brasileiros se auto declararam com sintomas depressivos, com prevalência naqueles com 60 anos ou mais (23,5%) e nas mulheres (27,74%). Tanto o uso de tabaco quanto a autopercepção de problemas de depressão foram inversamente proporcionais ao nível de escolaridade. Não houve significância estatística na correlação do perfil sociodemográfico com o tabagismo ou com a depressão. Apesar da literatura apresentar uma relação de influência mútua entre o uso do tabaco e os sintomas depressivos, não foi possível correlacionar diretamente ambas condições clínicas devido a precariedade dos dados disponíveis. Ainda assim, evidencia-se a necessidade de políticas públicas mais efetivas e atuais, pois trata-se de um problema relevante. Ademais, sugere-se uma maior eficácia no processo de  notificação, disponibilização e atualização dos dados provenientes do DATASUS para um melhor direcionamento de estudos futuros

Vivências do cuidado de enfermagem em unidade de diálise: relato de experiência

Objetivo: Relatar a experiência vivenciada por uma discente de enfermagem ao cuidar de pacientes renais em hemodiálise. Método: Estudo descritivo do tipo relato de experiência realizado em uma unidade de diálise na região Nordeste do Brasil. Resultados: Os profissionais de enfermagem desenvolvem assistência direta aos pacientes, antes, durante e após a sessão de hemodiálise, com ênfase na monitoração dos sinais vitais e na prevenção de complicações. Conclusão: A discente vivenciou o processo de trabalho da equipe de enfermagem no cuidado ao paciente renal, atuando na prevenção e atendimento das principais complicações decorrentes do procedimento dialítico, visando a reduzir danos e a elevar a qualidade assistencial

Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.

Submitted by Nuzia Santos ([email protected]) on 2018-12-21T18:22:41Z No. of bitstreams: 1 Inhibition of tissue inflammation and bacterial translocation.pdf: 5745525 bytes, checksum: 20ce864a4910ae14276121be266f2f73 (MD5)Approved for entry into archive by Nuzia Santos ([email protected]) on 2018-12-21T18:27:26Z (GMT) No. of bitstreams: 1 Inhibition of tissue inflammation and bacterial translocation.pdf: 5745525 bytes, checksum: 20ce864a4910ae14276121be266f2f73 (MD5)Made available in DSpace on 2018-12-21T18:27:26Z (GMT). No. of bitstreams: 1 Inhibition of tissue inflammation and bacterial translocation.pdf: 5745525 bytes, checksum: 20ce864a4910ae14276121be266f2f73 (MD5) Previous issue date: 2013Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFaculdade de Fármacia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilGrowing evidences suggest that Saccharomyces boulardii (SB) is efficacious against bacterial infections and inflammatory bowel diseases. This study investigated the effects of treatment with SB provided in a murine model of typhoid fever. Mice were divided into two groups: (1) control animals challenged with Salmonella Typhimurium (ST), and (2) animals receiving SB, and then challenged with ST. At days 0, 1, 5, 10 and 15 post-challenge, animals were euthanized and tissues collected to analyze bacterial translocation, cytokines, signaling pathways and histological analysis. Survival rate and animal weight were also evaluated. Treatment with SB increased survival rate and inhibited translocation of bacteria after ST challenge. Histological data showed that SB also protected mice against liver damage induced by ST. SB decreased levels of inflammatory cytokines and activation of mitogen-activated protein kinases (p38, JNK and ERK1/2), phospho-IκB, p65-RelA, phospho-jun and c-fos in the colon, signal pathways involved in the activation of inflammation induced by ST. Further experiments revealed that probiotic effects were due, at least in part, to the binding of ST to the yeast. Such binding diminishes ST translocation, resulting in decreased activation of signaling pathways which lead to intestinal inflammation in a murine model of typhoid fever

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field