Trees of my life’ : an art-education experience that seeks to develop the look of the student’s living space

We intend to present a work done with classes of students of the 4th year of Elementary School I in Brazil, at Colégio de Aplicação João XXIII (Universidade Federal de Juiz de Fora). The theme -- tree -- had been proposed in class, as a triggering element of the process. As a kind of methodology and practice, this process can be applied to other topics in class, involving art and the spatial perception of the student universeinfo:eu-repo/semantics/publishedVersio

Artesanato e fé : narrativas de uma Mestra Griô sobre romarias e o Santuário de Padre Cícero

This article aims to reflect about the religious phenomenon and the sacred that encompasses the atmosphere of faith and devotion in Juazeiro do Norte, in the state of Ceará, Brazil. Through the embroidered, words woven and the master Griô’s narrative – ‘Dona Fanca’, the pilgrimages and the sanctuary of Padre Cícero demonstrate the look of one who makes from the narratives, its manual work, of witness of fait

Latin Ponchos : an artistic experience of creation and collective expression in the classroom

This project was developed with students of 8th-grade from Colégio dos Jesuítas’s Elementary School II, Juiz de Fora, Brazil. The intention is to reflect on how students, based on a sensitization, appreciation and contextualization, related to a thematic proposed by the teacher, develop their own ideas in groups, for the accomplishment of collective artistic works, where the authorship becomes dilutedinfo:eu-repo/semantics/publishedVersio

A pro-inflammatory microenvironment triggers overexpression of tumor-related RAC1B in polarized colorectal cancer cells

Understand how tumor cells respond to a pro-inflammatory microenvironment with changes in the alternative splicing of RAC1B.FCTN/

Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells

Simple Summary: Tumours are now known to develop more quickly when the tumour cell mass is located in a tissue that shows signs of chronic inflammation. Under such conditions, inflammatory cells from the surrounding tumour microenvironment provide survival signals to which cancer cells respond. We have previously found that some colorectal tumours overexpress the protein RAC1B that sustains tumour cell survival. Here we used a colon mucosa-like in vitro cell model and found that the presence of cancer-associated fibroblasts and pro-inflammatory macrophages stimulated colorectal cells to increase their RAC1B levels. Under these conditions, the secreted survival signals were analysed, and interleukin-6 identified as the main trigger for the increase in RAC1B levels. The results contribute to understand the tumour-promoting effect of inflammation at the molecular level.Abstract: An inflammatory microenvironment is a tumour-promoting condition that provides survival signals to which cancer cells respond with gene expression changes. One example is the alternative splicing variant Rat Sarcoma Viral Oncogene Homolog (Ras)-Related C3 Botulinum Toxin Substrate 1 (RAC1)B, which we previously identified in a subset of V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF)-mutated colorectal tumours. RAC1B was also increased in samples from inflammatory bowel disease patients or in an acute colitis mouse model. Here, we used an epithelial-like layer of polarized Caco-2 or T84 colorectal cancer (CRC) cells in co-culture with fibroblasts, monocytes or macrophages and analysed the effect on RAC1B expression in the CRC cells by RT-PCR, Western blot and confocal fluorescence microscopy. We found that the presence of cancer-associated fibroblasts and M1 macrophages induced the most significant increase in RAC1B levels in the polarized CRC cells, accompanied by a progressive loss of epithelial organization. Under these conditions, we identified interleukin (IL)-6 as the main trigger for the increase in RAC1B levels, associated with Signal Transducer and Activator of Transcription (STAT)3 activation. IL-6 neutralization by a specific antibody abrogated both RAC1B overexpression and STAT3 phosphorylation in polarized CRC cells. Our data identify that pro-inflammatory extracellular signals from stromal cells can trigger the overexpression of tumour-related RAC1B in polarized CRC cells. The results will help to understand the tumour-promoting effect of inflammation and identify novel therapeutic strategies.Work in the authors’ laboratory was supported by Fundação para a Ciência e Tecnologia (FCT) (through grant UID/MULTI/04046/2019 to Research Unit BioISI, grant PTDC/BIA-MOL/28386/2017, and fellowship BD/109162/2015 to J.F.S.P.) and by the Portuguese association of the intestinal inflammatory disease (grant GEDII 2013 to P.J.).info:eu-repo/semantics/publishedVersio

A violência está no ar

Este artigo apresenta uma reflexão sobre o propósito das imagens e a origem de modelos compositivos, a partir da iconografia da violência coletiva. Procura-se ainda, propor um modelo de intencionalidade das imagens na arte antiga do mediterrâneo e na arte do Brasil, desde a pré-história ao século XXI

The looks on the portuguese art : students of the Portuguese Culture Studies at the University Mohammed V, of Rabat, Morocco

We intend to reflect on the teaching of Portuguese Art History and the importance of this discipline in the knowledge of a culture, from the analysis of the works presented by students of the Degree in Portuguese Studies, University Mohammed V in Rabatinfo:eu-repo/semantics/publishedVersio