Exploitation and Processing of Online Information for Annotating and Generating Texts Adapted to the User

La gran cantidad de información disponible en Internet está dificultando cada vez más que los usuarios puedan digerir toda esa información, siendo actualmente casi impensable sin la ayuda de herramientas basadas en las Tecnologías del Lenguaje Humano (TLH), como pueden ser los recuperadores de información o resumidores automáticos. El interés de este proyecto emergente (y por tanto, su objetivo principal) viene motivado precisamente por la necesidad de definir y crear un marco tecnológico basado en TLH, capaz de procesar y anotar semánticamente la información, así como permitir la generación de información de forma automática, flexibilizando el tipo de información a presentar y adaptándola a las necesidades de los usuarios. En este artículo se proporciona una visión general de este proyecto, centrándonos en la arquitectura propuesta y el estado actual del mismo.The great amount of available online information is making increasingly more and more difficult that users can assimilate such as volume of information, being this almost inconceivable without using Human Language Technologies (HLT) tools, for instance, information retrieval systems or automatic summarisers. The interest of this emerging project (and therefore its main goal) is precisely motivated by the need to define and create a HLT-based technological framework, able to process and semantically annotate all this information, allowing also the automatic generation of information, and making the type of information to be presented more flexible by adapting it to the users' needs. This article provides an overview of this project, focusing on the proposed architecture and its current status.Este proyecto ha sido financiado por la Universidad de Alicante a través del proyecto emergente “Explotación y tratamiento de la información disponible en Internet para la anotación y generación de textos adaptados al usuario” (GRE13-15) y su temática se enmarca en el contexto de los proyectos “DIIM2.0: Desarrollo de técnicas Inteligentes e Interactivas de Minería y Generación de Información sobre la Web 2.0” (PROMETEOII/2014/001) financiado por la Generalitat Valenciana y el proyecto “Técnicas de Deconstrucción en la Tecnologías del Lenguaje Humano” (TIN2012-31224) financiado por Ministerio de Economía y Competitividad del Gobierno de España

Intelligent information processing to support decision-making

Proyecto emergente centrado en el tratamiento inteligente de información procedente de diversas fuentes tales como micro-blogs, blogs, foros, portales especializados, etc. La finalidad es generar conocimiento a partir de la información semántica recuperada. Como resultado se podrán determinar las necesidades de los usuarios o mejorar la reputación de diferentes organizaciones. En este artículo se describen los problemas abordados, la hipótesis de trabajo, las tareas a realizar y los objetivos parciales alcanzados.This project is focused on intelligent information processing using different sources such as micro-blogs, blogs, forums, specialized websites, etc. The goal is to obtain new knowledge using semantic information. As a result we can determine user requirements or improve organizations reputation. This paper describes the problems faced, working hypothesis, tasks proposed and goals currently achieved

Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells

Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines; however, uncontrolled virus replication in vulnerable tissues can give pathology and often restricts the use of potent strains. Increased knowledge of tissue-selective microRNA expression now affords the possibility of engineering replicating viruses that are attenuated at the RNA level in sites of potential pathology, but retain wild-type replication activity at sites not expressing the relevant microRNA. To assess the usefulness of this approach for the DNA virus adenovirus, we have engineered a hepatocyte-safe wild-type adenovirus 5 (Ad5), which normally mediates significant toxicity and is potentially lethal in mice. To do this, we have included binding sites for hepatocyte-selective microRNA mir-122 within the 39 UTR of the E1A transcription cassette. Imaging versions of these viruses, produced by fusing E1A with luciferase, showed that inclusion of mir-122 binding sites caused up to 80-fold decreased hepatic expression of E1A following intravenous delivery to mice. Animals administered a ten-times lethal dose of wild-type Ad5 (5610 10 viral particles/mouse) showed substantial hepatic genome replication and extensive liver pathology, while inclusion of 4 microRNA binding sites decreased replication 50-fold and virtually abrogated liver toxicity. This modified wild-type virus retained full activity within cancer cells and provided a potent, liver-safe oncolytic virus. In addition to providing many potent new viruses for cancer virotherapy, microRNA control of virus replication should provide a new strategy for designing safe attenuated vaccines applied across a broad range of viral disease

Effect of pruning strategy on 'Syrah' bud necrosis and fruitfulness in Brazilian subtropical Southeast

The change of wine grape harvest from wet season (summer) to dry season (winter) by changing the pruning management has improved quality of wines produced in the Brazilian Southeast. However, the vines need to be spur pruned twice a year, i.e. with a 1st pruning in August (winter pruning) for a vegetative cycle during the hot and wet summer, and a 2nd pruning in January (summer pruning) for a productive cycle during the cold and dry season. This double pruning strategy is made necessary by the fact that latent buds developed during the dry season cycle are not fruitful to support a productive cycle in the following year. This histological study, performed in the South of Minas Gerais State (Brazil), showed that annual single pruning done in the wet season (in January) displayed a high rate of necrosis on primary and secondary buds (bud necrosis – BN). In April, 99 days after summer pruning (DASP), the rates of BN were 40 % and 50 % at basal and apical node positions, respectively, reaching 80 % of BN in December (322 DASP). As a consequence of BN, bud potential fertility was drastically reduced from 0.5 inflorescence primordial (IP) per bud (in July) to 0.06 (in December) and bud burst in the next cycle from secondary and tertiary bud axes. Vines managed by double pruning system (submitted to summer and winter pruning) displayed a much higher fruitfulness potential, i.e. 1.46 IP per bud in December (112 days after winter pruning) and limited BN occurrence (20 %). On single pruned vines, we also observed a significant decrease of starch content in canes, trunks and roots. Internal bud anatomy showed that a random cell breakdown started 70 days DASP. At 211 DASP, all buds showed a large starch granule concentration, raphides and crystals of calcium oxalate inside idioblasts of leaf primordia and also in cortical parenchyma of the vegetative axis. The bud starch content was increased and a positive correlation between necrosis and starch accumulation was observed. The impact of carbohydrate availability on bud necrosis development was discussed. This study showed that the necrosis development towards secondary and tertiary axis of the dry season buds is the main reason of unfruitfulness in the vineyards managed by single pruning in the wet season, making the double pruning compulsory

Series Solution for the Time-Fractional Coupled mKdV Equation Using the Homotopy Analysis Method

We present new analytical approximated solutions for the space-time fractional nonlinear partial differential coupled mKdV equation. A homotopy analysis method is considered to obtain an infinite series solution. The effectiveness of this method is demonstrated by finding exact solutions of the fractional equation proposed, for the special case when the limit of the integral order of the time derivative is considered. The comparison shows a precise agreement between these solutions

Convocation

List of performers and performances

MicroRNA Controlled Adenovirus Mediates Anti-Cancer Efficacy without Affecting Endogenous MicroRNA Activity

MicroRNAs are small non-coding RNA molecules that regulate mRNA translation and stability by binding to complementary sequences usually within the 3′ un-translated region (UTR). We have previously shown that the hepatic toxicity caused by wild-type Adenovirus 5 (Ad5WT) in mice can be prevented by incorporating 4 binding sites for the liver-specific microRNA, mir122, into the 3′ UTR of E1A mRNA. This virus, termed Ad5mir122, is a promising virotherapy candidate and causes no obvious liver pathology. Herein we show that Ad5mir122 maintains wild-type lytic activity in cancer cells not expressing mir122 and assess any effects of possible mir122 depletion in host cells. Repeat administration of 2×1010 viral particles of Admir122 to HepG2 tumour bearing mice showed significant anti-cancer efficacy. RT-QPCR showed that E1A mRNA was down-regulated 29-fold in liver when compared to Ad5WT. Western blot for E1A confirmed that all protein variants were knocked down. RT-QPCR for mature mir122 in infected livers showed that quantity of mir122 remained unaffected. Genome wide mRNA microarray profiling of infected livers showed that although the transcript level of >3900 different mRNAs changed more than 2-fold following Ad5WT infection, less than 600 were changed by Ad5mir122. These were then filtered to select mRNAs that were only altered by Ad5mir122 and the remaining 21 mRNAs were compared to predicted mir122 targets. No mir122 target mRNAs were affected by Ad5 mir122. These results demonstrate that the exploitation of microRNA regulation to control virus replication does not necessarily affect the level of the microRNA or the endogenous mRNA targets