Long-term stability calculation of reservoir bank slope considering water-rock interaction

Rano upozorenje i prognoza oduvijek su ključne točke u istraživanju klizišta jer katastrofa koju izaziva klizište rezultira ogromnim gubitkom života i imetka. U radu se transformirani rezultati degradacije mase jedne stijene u odnosu na drugu primjenjuju u izračunu promjena stanja stabilnosti i propadanja klizišta tijekom vremena te kao vodič kroz eksperiment zasnovan na interakciji voda-stijena hidro fluktuacijskog pojasa područja akumulacije Three Gorges. Rezultati su pokazali da dok stijenska masa ne degradira do određene mjere, područje klizišta se povećava, klizna površina se kreće ka površini, spušta se napukla površina stražnjeg ruba i masa klizišta se postepeno sužava. Budući da se sposobnost hidro-fluktuacijskog pojasa da se odupre težini gornje stijenske mase smanjuje, hidro-fluktuacijski pojas se najprije urušava, a zatim dovodi do pucanja stražnjeg ruba što rezultira klizanjem velike količine stijenske mase. Doprinos stabilnosti klizišta svakog parametra u raznim slojevima proučava se analizom senzitivnosti. Na temelju toga parametar čvrstoće se može procijeniti i izračunati u kombinaciji s trajnim padom kvalitete hidro-fluktuacijskog pojasa. Parametar potpune čvrstoće može odražavati uključenu sposobnost klizišta da se odupre katastrofi. Rezultati istraživanja upućuju na postojeći projekt, a metode istraživanja predstavljaju novi način za rano upozorenje i predviđanje klizišta.Early warning and forecast have always been the key points for landslide research because the disaster caused by landslide leads to enormous life and property loss. This article applies the transformed degradation results of rock to rock mass to calculate the stability and failure mode changes of landslide over time, and to guide engineering through experiment based on hydro-fluctuation belt water-rock interaction of Three Gorges Reservoir area. The results showed that until the rock mass degrades to a certain extent, the sliding zone export gets rise, the slip plane moves to surface, the back edge crack surface gets down, and the sliding mass gradually narrows down. As the ability of hydro-fluctuation belt to resist upper rock mass load reduces, the hydro-fluctuation belt collapses at the first, and then causes the back edge crack resulting in huge amount of rock mass slip. The contribution of each parameter in different stratum to landslide stability is studied through sensitivity analysis. Based on this, the comprehensive strength parameter can be evaluated and calculated combined with continuous deterioration of hydro-fluctuation belt. The comprehensive strength parameter can reflect comprehensive disaster resist capacity of landslide. The research results provide a reference for actual project, and the research methods provide a new way for landslide early warning and forecast

2-Amino-4-tert-butyl-5-(2,4-dichloro­benz­yl)thia­zol-3-ium bromide

The asymmetric unit of the title compound, C14H17Cl2N2S+·Br−, contains one cation and two Br− ions with site symmetry . The dihedral angle between the planes of the thia­zol and the dichloro­phenyl rings is 77.8 (6)°. In the crystal, the ions are connected by N–H⋯Br hydrogen bonds

The Effectiveness of Cupping Therapy on Relieving Chronic Neck and Shoulder Pain: A Randomized Controlled Trial

The research aimed to investigate the effectiveness of cupping therapy (CT) in changes on skin surface temperature (SST) for relieving chronic neck and shoulder pain (NSP) among community residents. A single-blind experimental design constituted of sixty subjects with self-perceived NSP. The subjects were randomly allocated to two groups. The cupping group received CT at SI 15, GB 21, and LI 15 acupuncture points, and the control group received no intervention. Pain was assessed using the SST, visual analog scale (VAS), and blood pressure (BP). The main results were SST of GB 21 acupuncture point raised from 30.6°C to 32.7°C and from 30.7°C to 30.6°C in the control group. Neck pain intensity (NPI) severity scores were reduced from 9.7 to 3.6 in the cupping group and from 9.7 to 9.5 in the control group. The SST and NPI differences between the groups were statistically significant (P < 0.001). One treatment of CT is shown to increase SST. In conjunction with the physiological effect the subjective experience of NSP is reduced in intensity. Further studies are required to improve the understanding and potential long-term effects of CT

The Next Generation Virgo cluster Survey. V. modelling the dynamics of M87 with the Made-to-Measure method

We study the dynamics of the giant elliptical galaxy M87 from the central to the outermost regions with the made-to-measure (M2M) method. We use a new catalogue of 922 globular cluster line-of- sight velocities extending to a projected radius of 180 kpc (equivalent to 25 M87 effective radii), and SAURON integral field unit data within the central 2.4 kpc. 263 globular clusters, mainly located beyond 40 kpc, are newly observed by the Next Generation Virgo Survey (NGVS). For the M2M modelling, the gravitational potential is taken as a combination of a luminous matter potential with a constant stellar mass-to-light ratio and a dark matter potential modelled as a logarithmic potential. Our best dynamical model returns a stellar mass-to-light ratio in the I band of M/LI = 6.0(+ -0.3) M_sun/L_sun with a dark matter potential scale velocity of 591(+ -50) km/s and scale radius of 42(+ -10) kpc. We determine the total mass of M87 within 180 kpc to be (1.5 + - 0.2) 10^13 M_sun. The mass within 40 kpc is smaller than previous estimates determined using globular cluster kinematics that did not extend beyond 45 kpc. With our new globular cluster velocities at much larger radii, we see that globular clusters around 40 kpc show an anomalously large velocity dispersion which affected previous results. The mass we derived is in good agreement with that inferred from ROSAT X-ray observation out to 180 kpc. Within 30 kpc our mass is also consistent with that inferred from Chandra and XMM-Newton X-ray observations, while within 120 kpc it is about 20% smaller. The model velocity dispersion anisotropy beta parameter for the globular clusters in M87 is small, varying from -0.2 at the centre to 0.2 at 40 kpc, and gradually decreasing to zero at 120 kpc.Comment: 20 pages, 16 figures, Accepted by Ap

N′-(2-Hydr­oxy-5-chloro­benzyl­idene)-4-nitro­benzohydrazide methanol solvate

The title compound, C14H10ClN3O4·CH4O, was synthesized from the reaction of 5-chloro­salicylaldehyde with 4-nitro­benzohydrazide in methanol. The Schiff base mol­ecule is nearly planar, with a dihedral angle of 9.1 (3)° between the two benzene rings. The methanol solvent mol­ecules are linked to the Schiff base mol­ecules by N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming chains running parallel to the a axis

COVID-19 Epidemic Peer Support and Crisis Intervention Via Social Media

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.This article describes a peer support project developed and carried out by a group of experienced mental health professionals, organized to offer peer psychological support from overseas to healthcare professionals on the frontline of the COVID-19 outbreak in Wuhan, China. This pandemic extremely challenged the existing health care systems and caused severe mental distress to frontline healthcare workers. The authors describe the infrastructure of the team and a novel model of peer support and crisis intervention that utilized a popular social media application on smartphone. Such a model for intervention that can be used elsewhere in the face of current global pandemic, or future disaster response

Postpartum stress urinary incontinence: a clinical study of 6,302 cases in Jiangsu Province

Objectives: To investigate the prevalence and influencing factors of stress urinary incontinence (SUI) within 6–8 weeks postpartum in Jiangsu Province. Material and methods: We designed a multi-center cross-sectional study involving seven hospitals in Jiangsu province, and enrolled women who underwent postpartum examination at 6–8 weeks in these hospitals between July 2019 and June 2021. According to the presence or absence of SUI, the enrolled patients were divided into two groups: the SUI group and the non-SUI group, respectively. We assessed the general health status, noted the details of delivery, and checked the pelvic floor electromyographic parameters of the postpartum women in both groups. Results: Among 6,302 cases of postpartum women in Jiangsu province, there were 1,579 cases of SUI, with a prevalence of 25.06%. The prevalence of SUI increased significantly with age, BMI, increasing parity, coexisting constipation, organ prolapse, and diastasis recti abdominis. Compared to the non-SUI group, the SUI group had a lower mean value of the pre-baseline rest phase, shorter rise and fall times of fast muscle contractions, and a lower mean value of the endurance contraction phase. Multiple regression analysis revealed associations with weight (especially overweight and obesity), coexisting organ prolapse, constipation, parity, gestational week of delivery, mode of delivery, and mean value of endurance contraction phase. Conclusions: The prevalence of postpartum stress urinary incontinence in Jiangsu Province was 25.06%, and was linked to being overweight, parity &gt; 2, coexisting organ prolapse, constipation, and a decrease in the mean value of the endurance contraction phase of the electromyograph. In this report, we offer a theoretical basis for the effective prevention of postpartum SUI clinically

Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive and selective death of dopaminergic neurons. Orexin-A is involved in many biological effects of the body. It has been reported that orexin-A has protective effects in cellular models of PD. However, little is known about the protective effects of orexin-A in animal parkinsonian models and the cellular mechanism has not yet been fully clarified. The aim of this study was to evaluate the effects of orexin-A in MPTP mice model of PD as well as the possible neuroprotective mechanisms of orexin-A on dopaminergic neurons. The results from animal experiments demonstrated that orexin-A attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (TH) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. MPTP-treated mice showed cognitive impairments accompanied with significant motor deficiency. Orexin-A improved MPTP-induced impairments in both motor activity and spatial memory. Importantly, orexin-A increased the protein level of brain-derived neurotrophic factor (BDNF) in dopaminergic neurons of the substantia nigra. Furthermore, the protective effects of orexin-A on MPTP parkinsonian mice could be blocked by orexinergic receptor 1 (OX1R) antagonist, SB334867. In another set of experiments with SH-SY5Y dopaminergic cells, orexin-A significantly induced the expression of BDNF in a dose and time-dependent manner. The upregulation of BDNF is mainly concerned with PI3K and PKC signaling pathways via OX1R. The present study demonstrated that orexin-A exerted neuroprotective effects on MPTP parkinsonian mice, which may imply orexin-A as a potential therapeutic target for PD

Luteolin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting TGFBR1 Signaling

Vascular smooth muscle cell (VSMC) proliferation and migration play a critical role in the development of arterial remodeling during various vascular diseases including atherosclerosis, hypertension, and related diseases. Luteolin is a food-derived flavonoid that exerts protective effects on cardiovascular diseases. Here, we investigated whether transforming growth factor-β receptor 1 (TGFBR1) signaling underlies the inhibitory effects of luteolin on VSMC proliferation and migration. We found that luteolin reduced the proliferation and migration of VSMCs, specifically A7r5 and HASMC cells, in a dose-dependent manner, based on MTS and EdU, and Transwell and wound healing assays, respectively. We also demonstrated that it inhibited the expression of proliferation-related proteins including PCNA and Cyclin D1, as well as the migration-related proteins MMP2 and MMP9, in a dose-dependent manner by western blotting. In addition, luteolin dose-dependently inhibited the phosphorylation of TGFBR1, Smad2, and Smad3. Notably, adenovirus-mediated overexpression of TGFBR1 enhanced TGFBR1, Smad2, and Smad3 activation in VSMCs and partially blocked the inhibitory effect of luteolin on TGFBR1, Smad2, and Smad3. Moreover, overexpression of TGFBR1 rescued the inhibitory effects of luteolin on the proliferation and migration of VSMCs. Additionally, molecular docking showed that this compound could dock onto an agonist binding site of TGFBR1, and that the binding energy between luteolin and TGFBR1 was -10.194 kcal/mol. Simulations of molecular dynamics showed that TGFBR1-luteolin binding was stable. Collectively, these data demonstrated that luteolin might inhibit VSMC proliferation and migration by suppressing TGFBR1 signaling