Aristotelian Powers: Without Them, What Would Modern Science Do?

The volume brings together for the first time original essays by leading philosophers working on powers in relation to metaphysics, philosophy of natural and social science, philosophy of mind and action, epistemology, ethics and social and political philosophy. In each area, the concern is to show how a commitment to real causal powers affects discussion at the level in question. In metaphysics, for example, realism about powers is now recognized as providing an alternative to orthodox accounts of causation, modality, properties and laws. Dispositional realist philosophers of science, meanwhile, argue that a powers ontology allows for a proper account of the nature of scientific explanation. In the philosophy of mind there is the suggestion that agency is best understood in terms of the distinctive powers of human beings. Those who take virtue theoretic approaches in epistemology and ethics have long been interested in the powers that allow for knowledge and/or moral excellence. In social and political philosophy, finally, powers theorists are interested in the powers of sociological phenomena such as collectivities, institutions, roles and/or social relations, but also in the conditions of possibility for the cultivation of the powers of individuals. The book will be of interest to philosophers working in any of these areas, as well as to historians of philosophy, political theorists and critical realists

Ceteris paribus laws need machines to generate them

Most of the regularities that get represented as ‘laws’ in our sciences arise from, and are to be found regularly associated with, the successful operation of a nomological machine. Reference to the nomological machine must be included in the cp-clause of a cp-law if the entire cp-claim is to be true. We agree, for example, ‘ceteris paribus aspirins cure headaches’, but insist that they can only do so when swallowed by someone with the right physiological makeup and a headache. Besides providing a necessary condition on the truth of the cp-law claim, recognising the nomological machine has great practical importance. Referring to the nomological machine makes explicit where the regularities are to be found, which is of central importance to the use of cp-laws for prediction and manipulation. Equally important, bringing the nomological machine to the fore brings into focus the make-up of the machine—its parts, their powers and their arrangements—and its context case-by-case

Predators on marine fish farms in Tasmania

Marine aquaculture of the salmonids atlantic salmon (Salrno salar) and rainbow trout (Salmo gairdneri) is a rapidly growing industry in Tasmania. There is considerable damage to the fish on these farms by avian and mammalian predators. The mode by which these predators attack the fish on the farms allows for practical methods to reduce the loss of fish. Physically excluding predators from the fish is ultimately the only way to prevent this loss entirely. A total of six predators that interact with the farms are described and the necessity for the protection methods to be incorporated into the design of the farms prior to farm development is emphasised

Trapping and relocating seals from salmonid fish farms in Tasmania, 1990-2000: was it a success?

In an effort to reduce the impact of seals on fish farms, the trapping and relocation of seals at Tasmanian salmonid farms began in 1990. To the end of May 2000,353 identified individual seals had been trapped in 672 capture events. Most were non-breeding male Australian fur seals (Arctocephalus pusillus doriftrus). The number of seals captured increased (from four in 1990 ro a peak of 164 in 1998) with the size and extent of the farms, and an increase in salmon production from 55 tonnes in 1986/87 to almost 10000 tonnes in 1999/2000. Of 586 capture events 52% were of seals that had been captured more than once. When seals are recaptured following trapping and relocation, this occurs on average 25 days after capture. Capture-mark-recapture calculations show that many seals in the vicinity of fish farms are not 'trappable', suggesting that trapping is only effective for certain individuals. Some individuals are recaptured many times, reflecting the predisposition of some individuals to be captured ('trap-happy'). Interaction is seasonal, with most seals trapped during winter, between May and September. The assessment of trends in capture rates is problematic, due to the lack of capture effort information from the farms. A further confounding factor has been the change in management practice both between farms and over time, as the use of predator nets has become more widespread. Two seals trapped at fish farms and fitted with satellite transmitters before relocation have either not returned to the farm or returned to the vicinity of farms and not interacted with them, although on one occasion the individual was trapped. The effectiveness of the relocation program as a management tool to reduce seal interactions cannot be quantified from the relocation data per se, but relocation does not stop seals interacting with farms

Rabies elimination research: juxtaposing optimism, pragmatism and realism

More than 100 years of research has now been conducted into the prevention, control and elimination of rabies with safe and highly efficacious vaccines developed for use in human and animal populations. Domestic dogs are a major reservoir for rabies, and although considerable advances have been made towards the elimination and control of canine rabies in many parts of the world, the disease continues to kill tens of thousands of people every year in Africa and Asia. Policy efforts are now being directed towards a global target of zero human deaths from dog-mediated rabies by 2030 and the global elimination of canine rabies. Here we demonstrate how research provides a cause for optimism as to the feasibility of these goals through strategies based around mass dog vaccination. We summarize some of the pragmatic insights generated from rabies epidemiology and dog ecology research that can improve the design of dog vaccination strategies in low- and middle-income countries and which should encourage implementation without further delay. We also highlight the need for realism in reaching the feasible, although technically more difficult and longer-term goal of global elimination of canine rabies. Finally, we discuss how research on rabies has broader relevance to the control and elimination of a suite of diseases of current concern to human and animal health, providing an exemplar of the value of a ‘One Health’ approach

Evaluation of the Fiscal Costs and Consequences of Alzheimer’s Disease in Germany:Microsimulation of Patients’ and Caregivers’ Pathways

Background: Alzheimer’s disease is a severe condition, impacting individual’s wellbeing and independence in daily activities. Informal care provision is common and of great value to societies but is not without negative externalities to households and the broader economy. Objectives: Estimate the lifetime incremental fiscal consequences of Alzheimer’s disease in community-based individuals and their informal caregivers. Setting: The fiscal consequences of Alzheimer’s disease was modeled using the German government and social security perspective. Participants: Synthetic cohort containing 1,000 pairs of people with Alzheimer’s disease and their informal caregivers, compared to 1,000 demographically identical pairs from the general population. Design: Disease progression was modeled using published equations and a state-transition microsimulation framework. Labor participation, financial support and paid taxes were estimated according to cognitive decline and caregiving responsibilities using German labor statistics and tax rates. Healthcare costs were sourced from several German publications. Costs and life-years were discounted at 3% annually. Measurements: Results are reported as lifetime incremental differences in total tax revenue and transfer payments between the cohort affected by Alzheimer’s disease and their general population analogues. Results: The Alzheimer’s disease-affected pair was associated with net incremental fiscal losses of €74,288 ($85,037) to the German government and social security over the lifetime of people with Alzheimer’s disease. Most costs were lost taxes on employment earnings (48.4$65,209) less than their general population analogues. Financial support for informal and formal care accounted for 20.4%, and medical healthcare costs represented 24.0% of the incremental fiscal losses. Sensitivity analyses confirmed the robustness of the model results. In a cohort with early onset Alzheimer’s disease, incremental fiscal losses were predicted to be €118,533 ($114,209) over the lifetime of people with Alzheimer’s disease. Conclusions: Alzheimer’s disease externalities profoundly impact public economics for governments and should be considered to inform policy making and healthcare planning

Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)

Profiling of gene expression changes in mice harbouring the neurodegenerative Wlds mutation shows a strong correlation between changes in cell cycle pathways and altered vulnerability of terminally differentiated neurons

Estimating the functional form for the density dependence from life history data

Two contrasting approaches to the analysis of population dynamics are currently popular: demographic approaches where the associations between demographic rates and statistics summarizing the population dynamics are identified; and time series approaches where the associations between population dynamics, population density, and environmental covariates are investigated. In this paper, we develop an approach to combine these methods and apply it to detailed data from Soay sheep (Ovis aries). We examine how density dependence and climate contribute to fluctuations in population size via age- and sex-specific demographic rates, and how fluctuations in demographic structure influence population dynamics. Density dependence contributes most, followed by climatic variation, age structure fluctuations and interactions between density and climate. We then simplify the density-dependent, stochastic, age-structured demographic model and derive a new phenomenological time series which captures the dynamics better than previously selected functions. The simple method we develop has potential to provide substantial insight into the relative contributions of population and individual-level processes to the dynamics of populations in stochastic environments

Successful vaccination of BALB/c mice against human hookworm (Necator americanus): the immunological phenotype of the protective response

In this murine (BALB/c) model of necatoriasis, high levels of protection against challenge infection by Necator americanus larvae (n = 300) were afforded by successive vaccinations at 14-day intervals, either subcutaneously or percutaneously, with γ-irradiated N. americanus larvae (n = 300). Percutaneous vaccination was significantly more effective than the subcutaneous route, with pulmonary larval burdens at 3 days post-infection being reduced by 97.8% vs. 89.3%, respectively, after three immunisations (p < 0.05). No worms were recovered from the intestines of thrice vaccinated mice. Two percutaneous vaccinations also reduced worm burdens, by 57% in the lungs and 98% in the intestines; p < 0.05. In vaccinated animals, lung pathology (mainly haemorrhage) following infection was greatly reduced compared with non-vaccinated animals. In vaccinated mice (but not in non-vaccinated mice) mast cells accumulated in the skin and were degranulated. RT-PCR analyses of mRNAs in the skin of vaccinated animals indicated increased expression of IL-4 relative to γ-IFN. Lymphocytes from the axillary (skin-draining) lymph nodes of vaccinated mice, stimulated in vitro with concanavalin A, exhibited enhanced secretion of IL-4 protein and a higher Il-4/γ-IFN protein ratio than lymphocytes from non-vaccinated animals. In vaccinated mice, levels of IgG1 and IgG3 (directed against larval excretory/secretory products) were elevated for the most part compared with those in non-vaccinated animals. These data demonstrate the successful vaccination of BALB/c mice against human hookworm infection and suggest that a localised Th2 response may be important for conferring protection against necatoriasis

Obstetricians and Violence against Women

I argue that the American Congress of Obstetricians and Gynecologists (ACOG), as an organization and through its individual members, can and should be a far greater ally in the prevention of violence against women. Specifically, I argue that we need to pay attention to obstetrical practices that inadvertently contribute to the problem of violence against women. While intimate partner violence is a complex phenomenon, I focus on the coercive control of women and adherence to oppressive gender norms. Using physician response to alcohol use during pregnancy and court-ordered medical treatment as examples, I show how some obstetrical practices mirror the attitudes of abusive men insofar as they try to coercively control women\u27s behavior through manipulation and violence. To be greater allies in the prevention of violence against women, obstetricians should stop participating in practices that inadvertently perpetuate violence against women