3-d resistive MHD simulations of magnetic reconnection and the tearing mode instability in current sheets

Magnetic reconnection plays a critical role in many astrophysical processes where high energy emission is observed, e.g. particle acceleration, relativistic accretion powered outflows, pulsar winds and probably in dissipation of Poynting flux in GRBs. The magnetic field acts as a reservoir of energy and can dissipate its energy to thermal and kinetic energy via the tearing mode instability. We have performed 3d nonlinear MHD simulations of the tearing mode instability in a current sheet. Results from a temporal stability analysis in both the linear regime and weakly nonlinear (Rutherford) regime are compared to the numerical simulations. We observe magnetic island formation, island merging and oscillation once the instability has saturated. The growth in the linear regime is exponential in agreement with linear theory. In the second, Rutherford regime the island width grows linearly with time. We find that thermal energy produced in the current sheet strongly dominates the kinetic energy. Finally preliminary analysis indicates a P(k) 4.8 power law for the power spectral density which suggests that the tearing mode vortices play a role in setting up an energy cascade.Comment: 4 pages, 8 figures, accepted for publication in the International Journal of Modern Physics D, proceedings of HEPRO meeting, held in Dublin, in September 200

A multi-flow model for microquasars

We present a new picture for the central regions of Black Hole X-ray Binaries. In our view, these central regions have a multi-flow configuration which consists in (1) an outer standard accretion disc down to a transition radius r_J, (2) an inner magnetized accretion disc below r_J driving (3) a non relativistic self-collimated electron-proton jet surrounding, when adequate conditions for pair creation are met, (4) a ultra relativistic electron-positron beam. This accretion-ejection paradigm provides a simple explanation to the canonical spectral states, from radio to X/gamma-rays, by varying the transition radius r_J and disc accretion rate independently. Large values of r_J and low accretion rate correspond to Quiescent and Hard states. These states are characterized by the presence of a steady electron-proton MHD jet emitted by the disc below r_J. The hard X-ray component is expect to form at the jet basis. When r_J becomes smaller than the marginally stable orbit r_i, the whole disc resembles a standard accretion disc with no jet, characteristic of the Soft state. Intermediate states correspond to situations where r_J ~ r_i. At large accretion rate, an unsteady pair cascade process is triggered within the jet axis, giving birth to flares and ejection of relativistic pair blobs. This would correspond to the luminous intermediate state, with its associated superluminal motions.Comment: 12 pages, 3 figures. Proceedings of ``High Energies in the Highlands'', Fort-William, 27 June-1 July 200

Search For Oxygen in Cool DQ White Dwarf Atmospheres

We report new infrared spectroscopic observations of cool DQ white dwarfs by using Coolspec on the 2.7m Harlan-Smith Telescope. DQs have helium-rich atmospheres with traces of molecular carbon thought to be the result of convective dredge-up from their C/O interiors. Recent model calculations predict that oxygen should also be present in DQ atmospheres in detectable amounts. Our synthetic spectra calculations for He-rich white dwarfs with traces of C and O indicate that CO should be easily detected in the cool DQ atmospheres if present in the expected amounts. Determination of the oxygen abundance in the atmosphere will reveal the C/O ratio at the core/envelope boundary, constraining the important and uncertain ^{12}C(alpha,gamma)^{16}O reaction rate.Comment: 2 pages, 2 figures, to appear in proceedings of the 13th European Workshop on White Dwarf

Cytokine Reduction in the Treatment of Joint Conditions

The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradative enzymes, and by inhibition of reparative processes. The destructive action of cytokines such as interleukin-1, interleukin-6 and tumour necrosis factor-α can be modulated at multiple points associated either with cytokine production or with cytokine action. Potential agents for cytokine reduction include selective anti-cytokine antibodies, anticytokine receptor antibodies, cytokine receptor antagonist proteins, and soluble and chimeric cytokine receptor molecules. Pharmacologic regulation of IL-1 and TNFα remain primary targets for treatment of arthritis, and results of early clinical trials are promising. However, the results of long-term clinical trials will be required to support the value of anti-cytokine therapy in treatment of arthritis

Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor

AbstractObjectiveTo evaluate the in-vivo therapeutic efficacy ofN-iminoethyl-L-Lysine (L-NIL), a selective inhibitor of inducible nitric oxide synthase (iNOS) in a dose response study, on the progression of lesions in the experimental osteoarthritic (OA) dog model.DesignThe sectioning of the anterior cruciate ligament of the right stifle joint of mongrel dogs was done by a stab wound. Dogs were separated into experimental groups: Group 1 received no treatment, Groups 2, 3, and 4 received oral L-NIL (0.3, 1 or 10mg/kg/day, respectively) starting immediately after surgery. The OA dogs were killed at 12 weeks after surgery.ResultsMacroscopically, L-NIL decreased the size of the cartilage lesions on condyles and plateaus. The histologic severity of the cartilage lesions was decreased in the L-NIL-treated dogs. This effect was more pronounced at the highest dosage tested (3 and 10mg/kg/day).ConclusionsThis study confirms the effectiveness of L-NIL, a selective inhibitor of iNOS, in attenuating the progression of experimental OA. It also clearly shows that the effect is dose-dependent