Ideación suicida y violencia familiar en estudiantes escolarizados de una institución educativa de Lima metropolitana

La investigación tuvo como objetivo general determinar la relación de la ideación suicida y violencia familiar en estudiantes escolarizados de una institución educativa de educación secundaria. El enfoque fue cuantitativo, bajo un diseño no experimental, transversal, correlacional. La muestra estuvo conformada por 235 jóvenes estudiantes de 3° a 5° de secundaria (varones y mujeres), de un rango de edad de 14 a 17 años. Los instrumentos empleados fueron la Escala de Intencionalidad Suicida de Beck y el Cuestionario de Violencia Intrafamiliar en adolescentes. Los resultados determinaron que existe una relación entre la ideación suicida y la violencia familiar en adolescentes escolarizados de una Institución Educativa de Lima Metropolitana. La cual fue estadísticamente significativa con un coeficiente de correlación directo y moderado (rho = .437, p< .000)

Conocimiento y actitud hacia el virus del papiloma humano en adolescentes del balneario Tortugas, 2022

El presente estudio de investigación de tipo descriptivo a nivel correlacional, trasversal y cuyo objetivo general es conocer la relación entre Conocimiento y Actitud Hacia el Virus del Papiloma Humano en Adolescentes del Balneario Tortugas, 2022, por ello la población estuvo compuesta con 38 adolescentes que habitan en el Balneario Tortugas los cuales lograron cumplir con los criterios de inclusión. Para la recopilación de los datos se emplearon los siguientes instrumentos: cuestionario de conocimiento del Virus del Papiloma Humano y la escala de Actitud hacia el Virus del Papiloma Humano. Los datos se procesaron mediante el software SPSS versión 26, dándose las conclusiones: - El 50,0% de los adolescentes tienen un conocimiento bajo, el 42,1% un conocimiento medio y el 7,9% conocimiento alto. - El 57,9% de los adolescentes tienen una actitud inadecuada hacia el virus del Papiloma Humano y el 42,1% tienen actitud adecuada. - Si, existe relación significativa entre el conocimiento y la actitud hacia el Virus del Papiloma Humano en adolescentes del Balneario Tortugas, 2022

Routes of the Sagrada Desterro – a proposal of an interpretative route of the historical and cultural center of Florianópolis (SC)

O trabalho apresenta uma proposta de roteiro interpretativo, abrangendo o Centro Histórico de Florianópolis (SC), e tem como principal objetivo estabelecer relações entre o aproveitamento do patrimônio histórico-cultural da área em estudo e o desenvolvimento da atividade turística na capital catarinense. A metodologia de interpretação do patrimônio histórico, bem como a pesquisa bibliográfica e documental, a visita técnica e as orientações do Guia Brasileiro de Sinalização Turística serviram como base para esta pesquisa e para o estabelecimento de uma proposta de roteiro interpretativo, principal resultado deste estudo. Assim, a primeira parte do estudo discorre a respeito dos conceitos inerentes à elaboração de roteiros turísticos, destacando-se questões referentes ao patrimônio histórico e aos meios de interpretação. Na segunda parte, procurou-se realizar uma contextualização histórico-geográfica da área, apontando questões relacionadas às origens da ocupação de Florianópolis, relacionando-as às alterações na paisagem urbana. Finalmente, a terceira parte, traz como resultados deste estudo o levantamento de recursos turísticos disponíveis e a formatação de um roteiro turístico histórico-cultural, aqui apresentado e denominado Caminhos da Sagrada Desterro, incluindo considerações a respeito das etapas necessárias para sua viabilização. Palavras-chave: Patrimônio Histórico-Cultural. Roteiro Interpretativo. Centro Histórico de Florianópolis.El trabajo presenta una propuesta de recorrido interpretativo, abarcando el Centro Histórico de Florianópolis (SC), y tiene como principal objetivo, establecer relaciones entre el aprovechamiento del patrimonio histórico-cultural del área en estudio, y el desarrollo de la actividad turística en la capital catarinense. La metodología de interpretación del patrimonio histórico, como así también, la investigación bibliográfica y documental, la visita técnica y las orientaciones Luciana Noronha Pereira; Nicole Pelaez; Gilberto Jerônimo Pimentel Filho; Vivian Buchholz; Roselys Izabel Correa Santos - Caminhos da Sagrada Desterro ... de la Guía Brasileña de Señalización Turística, sirvieron como base para esta investigación y para el establecimiento de uma propuesta de recorrido interpretativo, principal resultado de este estudio. De esta manera, la primera parte del estudio, versa sobre dos conceptos inherentes a la elaboración de recorridos turísticos, destacándose cuestiones referentes al patrimônio histórico, y a los medios de interpretación. En la segunda parte, se procuró realizar uma contextualización histórico-geográfica del área, apuntando a cuestiones relacionadas a los orígenes de la ocupación de Florianópolis, relacionándolas a lãs alteraciones en el paisaje urbano. Finalmente, la tercera parte, trajo como resultados de este estudio, el levantamiento de recursos turísticos isponibles y la formatación de un recorrido turístico histórico cultural, aquí presentado y denominado “Caminhos da Sagrada Desterro”, incluyendo consideraciones respecto de las etapas necesarias para su viabilización. Palabras claves: Patrimonio Histórico Cultural. Recorrido Interpretativo. Centro Histórico de Florianópolis.This work proposes an interpretative route, taking in the Historical Center of Florianópolis (SC), with the main objective of establishing relationships between the use of the historical and cultural heritage of the study area and the development of tourism in this city, which is the capital of the State of Santa Catarina. The methodology used to interpret the historical heritage, as well as the bibliographic and documentary review, technical visit, and guidelines from the Guia Brasileiro de Sinalização Turística (Brazilian Guide to Tourism Signs) served as the basis for this research, and for establishing a proposal for an interpretative route, which is the principal result of this study. Thus, the first part of the study discusses the concepts inherent to the creation of tourism routes, highlighting issues relating to the historical heritage and the means of interpreting it. In the second part, it seeks to carry out a historical and geographical contextualization of the area, indicating issues related to the origins of the occupation of Florianópolics, and linking it to the alterations in the urban landscape. Finally, the third part brings, as the results of this study, an investigation of tourism resources available and the formation of a historical and cultural tourism route, which is presented and denominated Caminhos da Sagrada Desterro, including considerations regarding the stages needed to make it viable. Key words words: Historical and Cultural Heritage. Interpretative Route. Historical Center of Florianópolis

Open-source games for health, multiplayer and gamepads. Co-creating fun care with children with asthma, young adults with cystic fibrosis, elders with COPD

Without air pollution, our life expectancy would increase by 34 months. With a commons-based economy, each and every human could afford medical care (vs one in two today). How not to produce risks? How to foster mutual care? We, people across regions and disciplines, get engaged to value pluralism and collective wisdom. We embrace play as a natural way to experiment, socialize, learn. We document and share our work so that everyone can freely use, study, improve, adapt it. In traditional medtech, corporate experts build a technical tool to manage a disease. Sealed in a black box, its price make it unaffordable to some. At Breathing Games, volunteer, diverse contributors co-create an evolving, rewarding, immersive story to promote holistic health. Free to use, study, improve, its gratuity helps develop solidarity. We present here our games (Asthma Heroes, Asthmonautes, Rise); controllers (Spirotroller enhanced, Spirotroller gaming, Breathing gamepad); creation as research (game testing, controller testing, games co-creation, translations); our next steps (international study, game accessibility via Raspberry Pi, link to air pollution sensor); and our advocacy activities for health as commons

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

IDENTIDADE GASTRONÔMICA: A EXTENSÃO ACADÊMICA NA PRESERVAÇÃO DOS PATRIMÔNIOS CULTURAIS

Esse artigo apresenta uma a&ccedil;&atilde;o extensionista focada na manuten&ccedil;&atilde;o e preserva&ccedil;&atilde;o dos Patrim&ocirc;nios Culturais Gastron&ocirc;micos. Neste contexto a gastronomia tradicional &eacute; entendida como uma manifesta&ccedil;&atilde;o da identidade local e que representa a hist&oacute;ria e a cultura de um povo. O objetivo &eacute; discutir as formas de registro e dissemina&ccedil;&atilde;o dos modos alimentares das cozinhas locais e para tanto foi utilizada uma metodologia de identifica&ccedil;&atilde;o dos saberes e fazeres da gastronomia tradicional, bem como a realiza&ccedil;&atilde;o de oficinas, palestras e eventos gastron&ocirc;micos. Os resultados obtidos na extens&atilde;o foram a intera&ccedil;&atilde;o da escola com a comunidade e a valoriza&ccedil;&atilde;o da cultura local

El niño y las lluvias de la estación seca influyen en la fenología de las plantas hospedantes y en una migración anual de mariposas de los bosques neotropicales húmedos a secos

We censused butterflies flying across the Panama Canal at Barro Colorado Island (BCI) for 16 years and butterfly hostplants for 8 years to address the question: What environmental factors influence the timing and magnitude of migrating Aphrissa statira butterflies? The peak migration date was earlier when the wet season began earlier and when soil moisture content in the dry season preceding the migration was higher. The peak migration date was also positively associated with peak leaf flushing of one hostplant (Callichlamys latifolia ) but not another (Xylophragma seemannianum ). The quantity of migrants was correlated with the El Niño Southern Oscillation, which influenced April soil moisture on BCI and total rainfall in the dry season. Both hostplant species responded to El Niño with greater leaf flushing, and the number of adults deriving from or laying eggs on those new leaves was greatest during El Niño years. The year 1993 was exceptional in that the number of butterflies migrating was lower than predicted by the El Niño event, yet the dry season was unusually wet for an El Niño year as well. Thus, dry season rainfall appears to be a primary driver of larval food production and population outbreaks for A. statira . Understanding how global climate cycles and local weather influence tropical insect migrations improves the predictability of ecological effects of climate change