2,965 research outputs found
In vitro antimicrobial and antiproliferative activity of amphipterygium adstringens
Amphipterygium adstringens is a plant widely used in Mexican traditional medicine for its known anti-inflammatory and antiulcer properties. In this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of A. adstringens against oral pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Candida albicans, and Candida dubliniensis, using microdilution (MIC) and agar diffusion methods (MBC), and the antiproliferative activity evaluating total growth inhibition (TGI) by staining the protein content with sulforhodamine B (SRB), using nine human cancer cell lines. Crude extract (CE) of A. adstringens showed some degree of activity against one or more of the strains with a MIC from 0.125 mg/mL to 63 mg/mL and MBC from 1.6 to 6.3 mg/mL and cytotoxic activity, particularly against NCI-ADR/RES, (a)n ovarian cell line expressing multiple resistance drugs phenotype. The CE is a complex mixture of possible multitarget metabolites that could be responsible for both antimicrobial and antiproliferative activities, and further investigation is required to elucidate the identity of active compounds. Nevertheless the CE itself is useful in the development of new antimicrobial treatment based on natural products to prevent oral diseases and as alternative natural source for cancer treatment and prevention2015PROMEP, Mexic
Antimicrobial Potential Of Some Plant Extracts Against Candida Species.
The increase in the resistance to antimicrobial drugs in use has attracted the attention of the scientific community, and medicinal plants have been extensively studied as alternative agents for the prevention of infections. The Candida genus yeast can become an opportunistic pathogen causing disease in immunosuppressive hosts. The purpose of this study was to evaluate dichloromethane and methanol extracts from Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum and Syzygium cumini against Candida species through the analysis of Minimum Inhibitory Concentration (MIC). Results presented activity of these extracts against Candida species, especially the methanol extract.701065-
On the renormalization group for the interacting massive scalar field theory in curved space
The effective action for the interacting massive scalar field in curved
space-time is derived using the heat-kernel method. Starting from this
effective action, we establish a smooth quadratic form of the low-energy
decoupling for the four-scalar coupling constant and for the nonminimal
interaction parameter. The evolution of this parameter from the conformal value
1/6 at high energies down to the IR regime is investigated within the two toy
models with negative and positive four-scalar coupling constants.Comment: LaTeX, 12 pages, 4 figure
Chemical composition of substrates on the rooting vigor of Caryocar brasiliense air layering.
The definition of vegetative propagation protocols is important for the production of Caryocar brasiliense Cambess plants, for the formation of commercial orchards. Therefore, the objective of this study was to evaluate the substrate’s chemical characteristics influence on Caryocar brasiliense air layering. For this, a randomized block experiment with five substrates was carried out in eight plants. The following substrates were evaluated: Bioplant® commercial substrate; coconut fiber; a mixture of Bioplant® and coconut fiber in (1:1; 1:3; 3:1) proportions. After 150 days, the air layers were cut and evaluations of survival, callusing and rooting percentages, root length, dry and fresh root matter, rooting vigor and lignification were carried out. In laboratory, chemical and physical characterizations of the substrates were undertaken. The results showed that the rooting percentage varied from 40% to 77%. Rooting of Caryocar brasiliense air layers is optimized when phosphorus, calcium, magnesium and CEC in the substrate are above 3.0 mg dm-3, 7.0 cmolc dm-3, 3.5 cmolc dm-3 and 17 cmolc dm-3, respectively. Sodium and sodium saturation of the substrate must be below 1.4 cmolc dm-3 and 6%, respectively. Strong, positive and significant correlations were observed between rooting and P, Ca, Mg and CEC
On the static solutions in gravity with massive scalar field in three dimensions
We investigate circularly symmetric static solutions in three-dimensional
gravity with a minimally coupled massive scalar field. We integrate numerically
the field equations assuming asymptotic flatness, where black holes do not
exist and a naked singularity is present. We also give a brief review on the
massless cases with cosmological constant.Comment: 11 pages, LaTeX, 1 Postscript figure. Some changes were don
A shadowing problem in the detection of overlapping communities: lifting the resolution limit through a cascading procedure
Community detection is the process of assigning nodes and links in
significant communities (e.g. clusters, function modules) and its development
has led to a better understanding of complex networks. When applied to sizable
networks, we argue that most detection algorithms correctly identify prominent
communities, but fail to do so across multiple scales. As a result, a
significant fraction of the network is left uncharted. We show that this
problem stems from larger or denser communities overshadowing smaller or
sparser ones, and that this effect accounts for most of the undetected
communities and unassigned links. We propose a generic cascading approach to
community detection that circumvents the problem. Using real and artificial
network datasets with three widely used community detection algorithms, we show
how a simple cascading procedure allows for the detection of the missing
communities. This work highlights a new detection limit of community structure,
and we hope that our approach can inspire better community detection
algorithms.Comment: 14 pages, 12 figures + supporting information (5 pages, 6 tables, 3
figures
Surface states and Rashba-type spin polarization in antiferromagnetic MnBiTe
The layered van der Waals antiferromagnet MnBiTe has been predicted
to combine the band ordering of archetypical topological insulators such as
BiTe with the magnetism of Mn, making this material a viable candidate
for the realization of various magnetic topological states. We have
systematically investigated the surface electronic structure of
MnBiTe(0001) single crystals by use of spin- and angle-resolved
photoelectron spectroscopy experiments. In line with theoretical predictions,
the results reveal a surface state in the bulk band gap and they provide
evidence for the influence of exchange interaction and spin-orbit coupling on
the surface electronic structure.Comment: Revised versio
Identification of candidate genes for reactivity in Guzerat (Bos indicus) cattle: a genome-wide association study.
Temperament is fundamental to animal production due to its direct influence on the animal-herdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and difficult to assess. Recently, a new quantitative system, REATEST®, for assessing reactivity, a phenotype of temperament, was developed. Herein, we describe the results of a Genome-wide association study for reactivity, assessed using REATEST® with a sample of 754 females from five dual-purpose (milk and meat production) Guzerat (Bos indicus) herds. Genotyping was performed using a 50k SNP chip and a two-step mixed model approach (Grammar-Gamma) with a one-by-one marker regression was used to identify QTLs. QTLs for reactivity were identified on chromosomes BTA1, BTA5, BTA14, and BTA25. Five intronic and two intergenic markers were significantly associated with reactivity. POU1F1, DRD3, VWA3A, ZBTB20, EPHA6, SNRPF and NTN4 were identified as candidate genes. Previous QTL reports for temperament traits, covering areas surrounding the SNPs/genes identified here, further corroborate these associations. The seven genes identified in the present study explain 20.5% of reactivity variance and give a better understanding of temperament biology
- …