Diseño de la red de distribución de agua potable de la zona 2 de la aldea Boca del Monte, Villa Canales, Guatemala

Diseñar una red de distribución de agua potable, así aplicar normas técnicas del Instituto de Fomento Municipal que rigen los sistemas de agua potable y realizar el diseño hidráulico de la línea de conducción y distribución de la zona

Articulación entre la matemática y el campo de acción de un futuro ingeniero de diseño de producto. Componentes de un proceso de modelación matemática

La literatura internacional reconoce la importancia de una enseñanza de las matemáticas articulada a las necesidades de formación de los futuros ingenieros. En este artículo se propone una modelación matemática en contextos situados a la ingeniería como una manera de promover esa articulación. Se desarrolló una investigación cualitativa en la que se analizaron las producciones orales y escritas de un conjunto de estudiantes que participaron de la elaboración de un proyecto de modelación matemática en ingeniería de diseño de producto. Los resultados sugieren que una estrategia de modelación matemática en contextos situados a la ingeniería debe integrar al menos cuatro aspectos, a saber: la contextualización, la problematización, la interacción con expertos y los diálogos entre disciplinas; y la manera como la formación matemática debe profundizar en las relaciones que se establecen entre los diferentes modelos matemáticos y no matemáticos al crear un diseño

La modelación matemática en las interacciones entre la matemática y el campo de acción de un futuro ingeniero

La literatura internacional resalta a la modelación matemática como un medio para que los estudiantes comprendan los conceptos matemáticos aplicados a su área de conocimiento y la matematización de diferentes procesos que desarrollan en su formación. Se analiza un episodio proveniente de una investigación cualitativa, que indaga por aspectos que en un ambiente de modelación matemática se articulan con el conocimiento matemático y con las necesidades de formación del ingeniero. Los resultados preliminares sugieren que conocimientos relativos a la ingeniería, otras ciencias y la matemática interactúen y se complementen en un ambiente de modelación matemática

Medidor-transmisor de aceleración (HIC/NIC)

El trabajo de grado se resume, en 2 dispositivos portátiles (uno Medidor-Transmisor y el otro Receptor-Visualizador) Con los cuales se es capaz de medir movimientos de aceleración (de hasta +/- 9 g) de un objeto en sus tres ejes cartesianos X, Y, Z.The Thesis is about 2 portable devices (one is a meter-transmitter and the other one is a receiver-visualizer) which are able to measure acceleration movements (from 0g to +/- 9g) of an object on its three Cartesian axes X, Y, Z.Ingeniero (a) ElectrónicoPregrad

Role of the vaccum pressure and temperature in the shape of metal Zn nanoparticles

Artículo especializado en revista indexadaZinc (Zn) nanoparticles were fabricated by the high-vacuum thermal evapouration technique. The vacuum pressure was modified from 10−6 to 15 Torr and the substrate temperature was increased from room temperature to 100◦C in order to evaluate the changes in the morphological and structural characteristics of the Zn nanoparticles. Well-faceted hexagonal disk shaped nanoparticles were formed at a vacuum pressure of 10−6 Torr with the substrate kept at room temperature. Aggregation and surface irregularities at the edges of the hexagonal nanodisks were observed with further increases in the vacuum pressure. The nanoscale characteristics of the nanodisks were lost at a vacuum pressure of 10−6 Torr and heating the substrate at 100◦C. The nanodisks were transformed into Zn wires at a vacuum pressure of 15 Torr with a substrate temperature of 100◦C. It is suggested that the initial stages of the growth of the Zn wires are governed by the agglomeration of the Zn nanodisks since the structure of the wires was observed to be composed by stacked nanodisks.CONACYT and PRODEP proyecto de red 2014-201

HGVA: the Human Genome Variation Archive.

High-profile genomic variation projects like the 1000 Genomes project or the Exome Aggregation Consortium, are generating a wealth of human genomic variation knowledge which can be used as an essential reference for identifying disease-causing genotypes. However, accessing these data, contrasting the various studies and integrating those data in downstream analyses remains cumbersome. The Human Genome Variation Archive (HGVA) tackles these challenges and facilitates access to genomic data for key reference projects in a clean, fast and integrated fashion. HGVA provides an efficient and intuitive web-interface for easy data mining, a comprehensive RESTful API and client libraries in Python, Java and JavaScript for fast programmatic access to its knowledge base. HGVA calculates population frequencies for these projects and enriches their data with variant annotation provided by CellBase, a rich and fast annotation solution. HGVA serves as a proof-of-concept of the genome analysis developments being carried out by the University of Cambridge together with UK's 100 000 genomes project and the National Institute for Health Research BioResource Rare-Diseases, in particular, deploying open-source for Computational Biology (OpenCB) software platform for storing and analyzing massive genomic datasets

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer