Regio- and stereoselective synthesis of acetallic tetrahydropyrans as building blocks for natural products preparation, via a tandem [4+3]-cycloaddition/ozonolysis Process

A highly versatile synthetic pathway is presented for the preparation of polyfunctionalized acetallic tetrahydropyrans from conveniently substituted 1-methoxy-8-oxabicyclo[3.2.1]- oct-6-en-3-one derivatives, as intermediates in the total synthesis of natural and unnatural products with structural, functional and/or biological importance. This synthetic methodology involves two key steps: a [4 + 3] cycloaddition reaction between an oxyallyl cation and 2-methoxyfuran as a diene, followed by oxidative and/or reductive ozonolysis of the cycloheptenone subunit. This sequence renders polyfunctionalized 2-methoxytetrahydropyranic products capable of being easily opened under acidic conditions. The key steps, cycloaddition and subsequent ozonolysis were both fully studied under different reaction conditions and using several substrates in order to optimize yields and stereoselectivities and to study the scope of the methodology. It is noteworthy that both reactions proceed with high diastereoselectivity and, in the case of the oxidative ozonolysis, outstanding regioselectivity as well. A chemical library of 14 polyfunctionalized tetrahydrofurans, having five or seven stereocenters, has been prepared using the detailed approach

Mobility assessment in people with Alzheimer disease using smartphone sensors

[EN] Background Understanding the functional status of people with Alzheimer Disease (AD), both in a single (ST) and cognitive dual task (DT) activities is essential for identifying signs of early-stage neurodegeneration. This study aims to compare the performance quality of several tasks using sensors embedded in an Android device, among people at different stages of Alzheimer and people without dementia. The secondary aim is to analyze the effect of cognitive task performance on mobility tasks. Methods This is a cross-sectional study including 22 participants in the control group (CG), 18 in the group with mild AD and 22 in the group with moderate AD. They performed two mobility tests, under ST and DT conditions, which were registered using an Android device. Postural control was measured by medial-lateral and anterior-posterior displacements of the COM (MLDisp and APDisp, respectively) and gait, with the vertical and medial-lateral range of the COM (Vrange and MLrange). Further, the sit-to-stand (PStand) and turning and sit power (PTurnSit), the total time required to complete the test and the reaction time were measured. Results There were no differences between the two AD stages either for ST or DT in any of the variables (p > 0.05). Nevertheless, people at both stages showed significantly lower values of PStand and PTurnSit and larger Total time and Reaction time compared to CG (p < 0.05). Further, Vrange is also lower in CDR1G than in CG (p < 0.05). The DT had a significant deleterious effect on MLDisp in all groups (p < 0.05) and on APDisp only in moderate AD for DT. Conclusions Our findings indicate that AD patients present impairments in some key functional abilities, such as gait, turning and sitting, sit to stand, and reaction time, both in mild and moderate AD. 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Assessment of Functional Activities in Individuals with Parkinson's Disease Using a Simple and Reliable Smartphone-Based Procedure

[EN] Parkinson's disease (PD) is a progressive neurodegenerative disorder leading to functional impairment. In order to monitor the progression of the disease and to implement individualized therapeutic approaches, functional assessments are paramount. The aim of this study was to determine the impact of PD on balance, gait, turn-to-sit and sit-to-stand by means of a single short-duration reliable test using a single inertial measurement unit embedded in a smartphone device. Study participants included 29 individuals with mild-to moderate PD (PG) and 31 age-matched healthy counterparts (CG). Functional assessment with FallSkip((R)) included postural control (i.e., Medial-Lateral (ML) and Anterior-Posterior (AP) displacements), gait (Vertical (V) and Medial-Lateral (ML) ranges), turn-to-sit (time) and sit-to-stand (power) tests, total time and gait reaction time. Our results disclosed a reliable procedure (intra-class correlation coefficient (ICC) = 0.58-0.92). PG displayed significantly larger ML and AP displacements during the postural test, a decrease in ML range while walking and a longer time needed to perform the turn-to-sit task than CG (p 0.05). In conclusion, people with mild-to-moderate PD exhibit impaired postural control, altered gait strategy and slower turn-to-sit performance than age-matched healthy people.This project (IMAMCJ/2020/1) was funded by Instituto Valenciano de Competitividad Empresarial (IVACE) and by the Valencian Regional Government (IVACE-GVA).Serra-Añó, P.; Pedrero, J.; Inglés, M.; Aguilar-Rodríguez, M.; Vargas-Villanueva, I.; Lopez Pascual, J. (2020). Assessment of Functional Activities in Individuals with Parkinson's Disease Using a Simple and Reliable Smartphone-Based Procedure. International Journal of Environmental research and Public Health (Online). 17(11):1-13. https://doi.org/10.3390/ijerph17114123S1131711Soh, S.-E., McGinley, J. L., Watts, J. J., Iansek, R., Murphy, A. T., Menz, H. B., … Morris, M. E. 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Sensors, 19(14), 3103. doi:10.3390/s19143103Weiss, A., Herman, T., Mirelman, A., Shiratzky, S. S., Giladi, N., Barnes, L. L., … Hausdorff, J. M. (2019). The transition between turning and sitting in patients with Parkinson’s disease: A wearable device detects an unexpected sequence of events. Gait & Posture, 67, 224-229. doi:10.1016/j.gaitpost.2018.10.018Pham, M. H., Warmerdam, E., Elshehabi, M., Schlenstedt, C., Bergeest, L.-M., Heller, M., … Maetzler, W. (2018). Validation of a Lower Back «Wearable»-Based Sit-to-Stand and Stand-to-Sit Algorithm for Patients With Parkinson’s Disease and Older Adults in a Home-Like Environment. Frontiers in Neurology, 9. doi:10.3389/fneur.2018.00652González Rojas, H. A., Cuevas, P. C., Zayas Figueras, E. E., Foix, S. C., & Sánchez Egea, A. J. (2017). Time measurement characterization of stand-to-sit and sit-to-stand transitions by using a smartphone. 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APLICACIÓN DE ULTRASONIDOS PARA EL CONTROL DE ALGAS EN AGUAS REGENERADAS ALMACENADAS EN BALSAS DE RIEGO

[ES] En las regiones áridas y semiáridas las balsas de riego son infraestructuras que garantizan el suministro de agua a los cultivos. Sin embargo, favorecen la proliferación de algas provocando serios problemas en la calidad del agua que afectan negativamente a los sistemas de riego (filtración, emisores, elementos auxiliares,...). Ante esta problemática, el objetivo de este estudio fue evaluar, a escala real, el efecto de los ultrasonidos sobre parámetros físico-químicos y microbiológicos de interés agronómico en el agua de riego almacenada y sobre la presencia de algas en el agua. El ensayo se realizó en tres balsas de aguas regeneradas y una de agua suministrada por la Comunidad de Regantes del Campo de Cartagena, principalmente procedente del Trasvase Tajo-Segura. Equipos de emisión de ultrasonidos se instalaron en 2 de las 4 balsas para tratar de reducir la presencia de algas. Quincenalmente, se determinó la calidad del agua mediante una sonda multiparamétrica y el análisis de muestras de agua en laboratorio. Los resultados del experimento manifiestan que los ultrasonidos controlan el crecimiento de microalgas manteniendo la concentración de éstas en valores aceptables para evitar problemas de obturación en los sistemas de riego y mejorando por tanto la calidad del agua almacenada.Maestre Valero, J.; Pedrero Salcedo, F.; Soto García, M.; Alarcón, J. (2015). APLICACIÓN DE ULTRASONIDOS PARA EL CONTROL DE ALGAS EN AGUAS REGENERADAS ALMACENADAS EN BALSAS DE RIEGO. En XXXIII CONGRESO NACIONAL DE RIEGOS. Valencia 16-18 junio de 2015. Editorial Universitat Politècnica de València. https://doi.org/10.4995/CNRiegos.2015.1439OC

Innovación sanitaria en la gestión del riesgo de caídas de personas mayores en Atención Primaria

[ES] Las caídas son actualmente uno de los problemas de salud más frecuentes y graves en las personas mayores. La gestión sociosanitaria eficiente desde el punto de vista preventivo se destaca como uno de los objetivos principales para afrontar esta problemática. Para dar respuesta a ello, el IBV y el Hospital Universitario de la Ribera, gestionado por Ribera Salud II UTE Ley 18/82, llevan a cabo de forma conjunta una línea de investigación para desarrollar y validar nuevos avances tecnológicos. El proyecto que se presenta a continuación ha servido para conocer la aplicabilidad y utilidad de la herramienta FallSkip en el contexto de la consulta del médico de Atención Primaria. Se han valorado, entre otros aspectos, el tiempo y la facilidad de uso, así como la utilidad de la información proporcionada en la evaluación del riesgo de caídas respecto a los métodos convencionales basados en cuestionarios y escalas clínicas.Folch, B.; Donato, C.; Ruivo, M.; Ruiz, A.; Tapia, A.; Palop, V.; Pitarch Corresa, S.... (2019). Innovación sanitaria en la gestión del riesgo de caídas de personas mayores en Atención Primaria. Revista de Biomecánica (Online). (66). http://hdl.handle.net/10251/128736S6

Desarrollo de tecnologías para evaluar la funcionalidad de pacientes con prótesis de rodilla y su uso para el seguimiento clínico post-comercialización de productos sanitarios y la estimación de indicadores de gestión hospitalaria

Gomez Pellin, A.; Pedrero, J.; Peris Serra, JL.; Sinovas, I.; Atienza Vicente, CM.; Garrido Jaen, JD.; Bermejo Bosch, I.... (2019). Desarrollo de tecnologías para evaluar la funcionalidad de pacientes con prótesis de rodilla y su uso para el seguimiento clínico post-comercialización de productos sanitarios y la estimación de indicadores de gestión hospitalaria. Innovación biomecánica en Europa. (8):1-4. http://hdl.handle.net/10251/167980S14

Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention

Impact of Parkinson's Disease on Functional Mobility at Different Stages

[EN] Introduction: Specific functional assessments to determine the progression of Parkinson¿s Disease (PD) are important to slow down such progression and better plan rehabilitation. This study aimed to explore possible differences in the performance of different functional tasks included in a mobility test using sensors embedded in an Android device, in people at different PD stages. Materials and Methods: Eighty-seven participants with PD agreed to participate in this cross-sectional study. They were assessed once using an inertial sensor and variables related to functional status were recorded (i.e., MLDisp, APDisp, DispA, Vrange, MLRange, PTurnSit, PStand, TTime, and RTime). Results: There was significant impairment of the vertical range during gait between stages I and II. Further, when stages II and III were compared, the sit-to-stand power was significantly impaired, and the total time required to complete the test increased significantly (p < 0.05). Even more significant differences were obtained when stages I and III were compared, in particular, dysfunction in postural control, vertical range, sit to stand power and total time. Finally, there were no significant differences between stages in the medial-lateral displacements and reaction time (p > 0.05). Conclusion: Functional mobility becomes more significantly impaired in the PD population as the PD stages progress. This implies impaired postural control, decreased ability to sit down or stand up from a chair, increased metabolic cost during walking, and overall slowing-down of motor function.This work was supported by the Universitat de Valencia (INV19-01-13-07, 2019) and developed within the framework of the IBERUS project. Technological Network of Biomedical Engineering applied to degenerative pathologies of the neuromusculoskeletal system in clinical and outpatient settings (CER-20211003), CERVERA Network financed by the Ministry of Science and Innovation through the Centre for Industrial Technological Development (CDTI), charged to the General State Budgets 2021, and the Recovery, Transformation, and Resilience Plan.Mollà-Casanova, S.; Pedrero, J.; Inglés, M.; Lopez Pascual, J.; Muñoz-Gómez, E.; Aguilar-Rodríguez, M.; Sempere-Rubio, N.... (2022). Impact of Parkinson's Disease on Functional Mobility at Different Stages. Frontiers in Aging Neuroscience. 14:1-7. https://doi.org/10.3389/fnagi.2022.935841171

Tecnologías para el seguimiento clínico de productos sanitarios y estimación de indicadores de gestión hospitalaria basadas en la valoración funcional

[ES] El Instituto de Biomecánica (IBV) está poniendo a punto un innovador servicio de valoración funcional biomecánica y monitorización de la actividad diaria que permitirá conocer la evolución en el tiempo de pacientes con prótesis de rodilla. Este servicio ayudará a empresas fabricantes de producto sanitario a disponer de información clínica objetiva y relevante sobre el funcionamiento de sus productos, reforzando sus sistemas de vigilancia poscomercialización. Además, este servicio beneficiará a los centros hospitalarios permtiéndoles medir de forma objetiva la efectividad de sus intervenciones y tratamientos rehabilitadores, contribuyendo así a mejorar la gestión y aprovechamiento de sus recursos.El proyecto outcomes (Ref. IMDEEA/2019/20) cuenta con financiación desde 2018 mediante la convocatoria de ayudas del IVACE y cofinanciación en un 50% por la UE a través de FEDER.Gomez Pellin, A.; Pedrero, J.; Pitarch Corresa, S.; Peydro De Moya, MF.; Atienza Vicente, CM.; Peris Serra, JL.; Caprara, G. (2019). Tecnologías para el seguimiento clínico de productos sanitarios y estimación de indicadores de gestión hospitalaria basadas en la valoración funcional. Revista de Biomecánica (Online). (66):1-6. http://hdl.handle.net/10251/160605S166

Investigación en tecnologías de valoración funcional biomecánica para el seguimiento clínico objetivo y fiable de pacientes con prótesis de rodilla

Gomez Pellin, A.; Pedrero, J.; Pitarch Corresa, S.; Peydro De Moya, MF.; Martínez Pérez, M.; Tomás I Chenoll, J.; Caprara, G.... (2020). Investigación en tecnologías de valoración funcional biomecánica para el seguimiento clínico objetivo y fiable de pacientes con prótesis de rodilla. Innovación biomecánica en Europa. (9):1-6. http://hdl.handle.net/10251/169031S16