182 research outputs found
Observation and Spectroscopy of a Two-Electron Wigner Molecule in an Ultra-Clean Carbon Nanotube
Coulomb interactions can have a decisive effect on the ground state of
electronic systems. The simplest system in which interactions can play an
interesting role is that of two electrons on a string. In the presence of
strong interactions the two electrons are predicted to form a Wigner molecule,
separating to the ends of the string due to their mutual repulsion. This
spatial structure is believed to be clearly imprinted on the energy spectrum,
yet to date a direct measurement of such a spectrum in a controllable
one-dimensional setting is still missing. Here we use an ultra-clean suspended
carbon nanotube to realize this system in a tunable potential. Using tunneling
spectroscopy we measure the excitation spectra of two interacting carriers,
electrons or holes, and identify seven low-energy states characterized by their
spin and isospin quantum numbers. These states fall into two multiplets
according to their exchange symmetries. The formation of a strongly-interacting
Wigner molecule is evident from the small energy splitting measured between the
two multiplets, that is quenched by an order of magnitude compared to the
non-interacting value. Our ability to tune the two-electron state in space and
to study it for both electrons and holes provides an unambiguous demonstration
of the fundamental Wigner molecule state.Comment: SP and FK contributed equally to this wor
Numerical analysis of seismic wave amplification in Nice (France) and comparisons with experiments
The analysis of site effects is very important since the amplification of
seismic motion in some specific areas can be very strong. In this paper, the
site considered is located in the centre of Nice on the French Riviera. Site
effects are investigated considering a numerical approach (Boundary Element
Method) and are compared to experimental results (weak motion and
microtremors). The investigation of seismic site effects through numerical
approaches is interesting because it shows the dependency of the amplification
level on such parameters as wave velocity in surface soil layers, velocity
contrast with deep layers, seismic wave type, incidence and damping. In this
specific area of Nice, a one-dimensional (1D) analytical analysis of
amplification does not give a satisfactory estimation of the maximum reached
levels. A boundary element model is then proposed considering different wave
types (SH, P, SV) as the seismic loading. The alluvial basin is successively
assumed as an isotropic linear elastic medium and an isotropic linear
viscoelastic solid (standard solid). The thickness of the surface layer, its
mechanical properties, its general shape as well as the seismic wave type
involved have a great influence on the maximum amplification and the frequency
for which it occurs. For real earthquakes, the numerical results are in very
good agreement with experimental measurements for each motion component.
Two-dimensional basin effects are found to be very strong and are well
reproduced numerically
Agronomic performance and transcriptional analysis of carotenoid biosynthesis in fruits of transgenic HighCaro and control tomato lines under field conditions
Genetic manipulation of carotenoid biosynthesis in higher plants has been the objective of a number of biotechnology programs, e.g. the Golden Rice Program. However, tomato (Solanumlycopersicum L.), which naturally accumulates lycopene in fruits, has attracted the attention of many groups who have manipulated it to increase or diversify carotenoid accumulation. One of the most significant achievements was “HighCaro (HC),” a transgenic tomato plant constitutively expressing the tomato lycopene beta-cyclase (tLcy-b), that produces orange fruits due to the complete conversion of lycopene to β-carotene. In this article we report the results of a field trial conducted in Metaponto (Italy) on HC and on two control genotypes to evaluate the stability of the transgenic trait and their yield performances. Transcriptional regulation of eight genes involved in carotenogenesis was assayed by quantitative real-time PCR (qRT-PCR) analysis on fruits collected at four distinct development stages. Statistical analysis results demonstrated that in field conditions the transgene maintained its ability to induce the conversion of lycopene to β-carotene. Moreover, agronomic performances and fruit quality in the transgenic line were not impaired by this metabolic disturbance. Results of qRT-PCR analysis suggested that transcription of PSY-1, PDS and ZDS genes were developmentally regulated in both genotypes. Unexpectedly, Lcy-b expression in transgenic fruits was also developmentally regulated, despite the fact that the gene was driven by a constitutive promoter. Our data provide evidence that in photosynthetic cells a strict and aspecific mechanism controls the level of transcripts until the onset of chromoplasts differentiation, at which point a gene-specific control on transcription takes place
Scale relativity and fractal space-time: theory and applications
In the first part of this contribution, we review the development of the
theory of scale relativity and its geometric framework constructed in terms of
a fractal and nondifferentiable continuous space-time. This theory leads (i) to
a generalization of possible physically relevant fractal laws, written as
partial differential equation acting in the space of scales, and (ii) to a new
geometric foundation of quantum mechanics and gauge field theories and their
possible generalisations. In the second part, we discuss some examples of
application of the theory to various sciences, in particular in cases when the
theoretical predictions have been validated by new or updated observational and
experimental data. This includes predictions in physics and cosmology (value of
the QCD coupling and of the cosmological constant), to astrophysics and
gravitational structure formation (distances of extrasolar planets to their
stars, of Kuiper belt objects, value of solar and solar-like star cycles), to
sciences of life (log-periodic law for species punctuated evolution, human
development and society evolution), to Earth sciences (log-periodic
deceleration of the rate of California earthquakes and of Sichuan earthquake
replicas, critical law for the arctic sea ice extent) and tentative
applications to system biology.Comment: 63 pages, 14 figures. In : First International Conference on the
Evolution and Development of the Universe,8th - 9th October 2008, Paris,
Franc
A new fast multi-domain BEM to model seismic wave propagation and amplification in 3D geological structures
International audienceThe analysis of seismic wave propagation and amplification in complex geological structures raises the need for efficient and accurate numerical methods. The solution of the elastodynamic equations using traditional boundary element methods (BEMs) is greatly hindered by the fully-populated nature of the matrix equations arising from the discretization. In a previous study limited to homogeneous media, the present authors have established that the Fast Multipole (FM) method reduces the complexity of a 3-D elastodynamic BEM to per GMRES iteration and demonstrated its effectiveness on 3-D canyon configurations. In this article, the frequency-domain FM-BEM methodology is extented to 3-D elastic wave propagation in piecewise-homogeneous domains in the form of a FM-accelerated multi-region BE-BE coupling approach. This new method considerably enhances the capability of the BEM for studying the propagation of seismic waves in 3-D alluvial basins of arbitrary geometry embedded in semi-infinite media. Several fully 3-D examples (oblique SV-waves) representative of such configurations validate and demonstrate the capabilities of the multi-domain fast multipole approach. They include comparisons with available (low-frequency) results for various types of incident wavefields, and time-domain results obtained by means of Fourier synthesis
Glutathione Deficiency in Cardiac Patients Is Related to the Functional Status and Structural Cardiac Abnormalities
International audienceBACKGROUND: The tripeptide glutathione (L-gamma-glutamyl-cysteinyl-glycine) is essential to cell survival, and deficiency in cardiac and systemic glutathione relates to heart failure progression and cardiac remodelling in animal models. Accordingly, we investigated cardiac and blood glutathione levels in patients of different functional classes and with different structural heart diseases. METHODS: Glutathione was measured using standard enzymatic recycling method in venous blood samples obtained from 91 individuals, including 15 healthy volunteers and 76 patients of New York Heart Association (NYHA) functional class I to IV, undergoing cardiac surgery for coronary artery disease, aortic stenosis or terminal cardiomyopathy. Glutathione was also quantified in right atrial appendages obtained at the time of surgery. RESULTS: In atrial tissue, glutathione was severely depleted (-58%) in NYHA class IV patients compared to NYHA class I patients (P = 0.002). In patients with coronary artery disease, this depletion was related to the severity of left ventricular dysfunction (P = 0.006). Compared to healthy controls, blood glutathione was decreased by 21% in NYHA class I patients with structural cardiac disease (P<0.01), and by 40% in symptomatic patients of NYHA class II to IV (P<0.0001). According to the functional NYHA class, significant depletion in blood glutathione occurred before detectable elevation in blood sTNFR1, a marker of symptomatic heart failure severity, as shown by the exponential relationship between these two parameters in the whole cohort of patients (r = 0.88). CONCLUSIONS: This study provides evidence that cardiac and systemic glutathione deficiency is related to the functional status and structural cardiac abnormalities of patients with cardiac diseases. These data also suggest that blood glutathione test may be an interesting new biomarker to detect asymptomatic patients with structural cardiac abnormalities
Characterization of transcriptome dynamics during watermelon fruit development: sequencing, assembly, annotation and gene expression profiles
<p>Abstract</p> <p>Background</p> <p>Cultivated watermelon [<it>Citrullus lanatus </it>(Thunb.) Matsum. & Nakai var. <it>lanatus</it>] is an important agriculture crop world-wide. The fruit of watermelon undergoes distinct stages of development with dramatic changes in its size, color, sweetness, texture and aroma. In order to better understand the genetic and molecular basis of these changes and significantly expand the watermelon transcript catalog, we have selected four critical stages of watermelon fruit development and used Roche/454 next-generation sequencing technology to generate a large expressed sequence tag (EST) dataset and a comprehensive transcriptome profile for watermelon fruit flesh tissues.</p> <p>Results</p> <p>We performed half Roche/454 GS-FLX run for each of the four watermelon fruit developmental stages (immature white, white-pink flesh, red flesh and over-ripe) and obtained 577,023 high quality ESTs with an average length of 302.8 bp. <it>De novo </it>assembly of these ESTs together with 11,786 watermelon ESTs collected from GenBank produced 75,068 unigenes with a total length of approximately 31.8 Mb. Overall 54.9% of the unigenes showed significant similarities to known sequences in GenBank non-redundant (nr) protein database and around two-thirds of them matched proteins of cucumber, the most closely-related species with a sequenced genome. The unigenes were further assigned with gene ontology (GO) terms and mapped to biochemical pathways. More than 5,000 SSRs were identified from the EST collection. Furthermore we carried out digital gene expression analysis of these ESTs and identified 3,023 genes that were differentially expressed during watermelon fruit development and ripening, which provided novel insights into watermelon fruit biology and a comprehensive resource of candidate genes for future functional analysis. We then generated profiles of several interesting metabolites that are important to fruit quality including pigmentation and sweetness. Integrative analysis of metabolite and digital gene expression profiles helped elucidating molecular mechanisms governing these important quality-related traits during watermelon fruit development.</p> <p>Conclusion</p> <p>We have generated a large collection of watermelon ESTs, which represents a significant expansion of the current transcript catalog of watermelon and a valuable resource for future studies on the genomics of watermelon and other closely-related species. Digital expression analysis of this EST collection allowed us to identify a large set of genes that were differentially expressed during watermelon fruit development and ripening, which provide a rich source of candidates for future functional analysis and represent a valuable increase in our knowledge base of watermelon fruit biology.</p
The lycopene β-cyclase plays a significant role in provitamin A biosynthesis in wheat endosperm
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