Tazewell Pike : cultural preservation : what are the qualities that make this neighborhood a special place and can they be protected?

The purpose of this thesis is to identify what, if anything, Tazewell Pike can do to prevent the destruction of qualities that give it a sense of place in a defined area. The neighborhood known as Tazewell Pike has a diverse architectural style consisting of many historic properties. Current trends of development along Tazewell Pike have enabled developers to acquire large tracks of land and divide them into subdivisions for single family dwellings. This is destroying the qualities of the neighborhood, which is known for its collection of historic buildings and scenic qualities. This study will look to identify several qualities affecting Tazewell Pike. These qualities are: To identify the Cultural, Architectural, and environmental aspects of place as well as scenic views and vistas, setting context, landscape features, and image that make Tazewell Pike a special place. To identify the current trends of development along Tazewell Pike, and To find out how other places with similar qualities and trends as those facing Tazewell Pike have been successful in conserving their desirable qualities

THE ISLAMIC WORLD AND THE LATIN EAST: WILLIAM OF TRIPOLI AND HIS SYRIAN CONTEXT

For nearly two centuries after the First Crusade, a Latin-Christian elite controlled significant parts of the eastern Mediterranean, home to a diverse array of Christians, Muslims, and Jews. While seemingly a rich context for inter-religious cultural exchange, the dominant historical narrative has called this society a form of “proto-Apartheid,” with Frankish rulers successfully erecting impermeable boundaries between themselves and their largely Arabic-speaking subjects.This dissertation challenges this narrative through an investigation of the life and work of William of Tripoli, a thirteenth-century Dominican born in modern Lebanon, who spent his career evangelizing Muslims from a priory in Akko (Acre, Israel). William wrote two treatises on Islam that have been called “peculiar,” because of their positive portrayal of both the Qurʾān and the Prophet Muḥammad, but have not otherwise been integrated into our understanding of the cultural milieu of the Latin East.argue that the “peculiar” elements in William’s work were borrowed from Arabic-Christian and Muslim sources, and that his entire rhetorical approach to Islam was informed by them. Through a contextualization of his work, I show that the religious, cultural, and social barriers of the Latin East were far more permeable than prior scholarship has acknowledged. Living and working alongside Muslims and eastern Christians cultivated within the Franks of the Latin East a uniquely Latin Eastern perspective. This was defined, above all, by the mental and emotional flexibility to interact with one’s neighbors from different sectarian communities in any of the ways that the context required, even while disagreeing with them in a broad, religious sense. William of Tripoli is the best written example we have of this perspective. He sought a pia interpretatio, or a pious interpretation of the Qurʾān, two centuries before this term was coined, because personal engagement with Islam had convinced him this was the best way to accomplish his missionary goals

F.I.T. Our Challenge, Our Purpose, and What We Can Do For You

Our group was given the task of creating a wellness program for Biss Enterprises. The launch of the FIT program for Biss Enterprises will be a great benefit to the company as well as its employees. These types of programs have been shown to reduce health care costs and employee absenteeism while increasing employee productivity. Not only is wellness meant to improve the employee\u27s physical health, but also their mental health and social health outside of work

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

The β-coronavirus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent of the global Covid-19 pandemic. Coronaviral Envelope (E) proteins are pentameric viroporins that play essential roles in assembly, release and pathogenesis. We developed a non-disruptive tagging strategy for SARS-CoV-2 E and find that at steady-state, it localises to the Golgi and to lysosomes. We identify sequences in E, conserved across Coronaviridae, responsible for Endoplasmic Reticulum (ER)-to-Golgi export, and relate this activity to interaction with COP-II via SEC24. Using proximity biotinylation, we identify an ADP Ribosylation Factor-1/Adaptor Protein-1 (ARFRP1/AP-1) dependent pathway allowing Golgi-to-lysosome trafficking of E. We identify sequences in E that bind AP-1, are conserved across β-coronaviruses and allow E to be trafficked from Golgi to lysosomes. We show that E acts to deacidify lysosomes and by developing a trans-complementation assay for SARS-CoV-2 structural proteins, we show that lysosomal delivery of E and its viroporin activity are necessary for efficient viral replication and release

Remarkable Male Bias in a Population of Midland Painted Turtles (Chrysemys picta marginata) in Ontario, Canada

We report on male sex bias in a population of Midland Painted Turtle (Chrysemys picta marginata) at a wetland near Brampton, Ontario, Canada. The wetland is bisected by a major arterial road and characterized by high traffic volume and substantial wildlife-vehicle collisions. Road mortality surveys conducted in 2011, 2013, and 2015 documented 217 dead turtles, of which 118 could positively be identified as Midland Painted Turtle. From 2014–2015, we conducted a mark-recapture survey and captured 34 individual Midland Painted Turtles. The male:female sex ratio of 21:4 is one of the most skewed sex ratios for this species on record. We attribute this skew to sex-specific road mortality amongst other possible factors such as predation and nesting conditions. This study adds to the general body of work that has found a male sex ratio bias in areas of high road mortality

The internet of food things: Adding values to the digitalisation of the UK food supply chain

The Internet of Things (IoT) is beginning to have a pronounced impact on the digitalised food manufacturing chain. Whilst the food chain is becoming at once more complex and more critical, the application of IoT has begun to be recognised as a key component of this transformation. However, exactly what the IoT is, or is not, is both evolving and provoking a lively debate. New clarifiers are being added to the term such as the Internet of Industrial Things and the Autonomous Internet of Things to ostensibly help clarify the terminology. For the purposes of the Internet of Food Things Network Plus, our conceptual and physical platform is predicated on the idea of a secure and trustworthy network based on open standards, where-possible commodity devices, and underpinned by societally ratified regulatory arrangements

Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates

AbstractHerein we show for the first time that Schistosoma mansoni adult worms secrete exosome-like extracellular vesicles ranging from 50 to 130nm in size. Extracellular vesicles were collected from the excretory/secretory products of cultured adult flukes and purified by Optiprep density gradient, resulting in highly pure extracellular vesicle preparations as confirmed by transmission electron microscopy and Nanosight tracking analysis. Extracellular vesicle proteomic analysis showed numerous known vaccine candidates, potential virulence factors and molecules implicated in feeding. These findings provide new avenues for the exploration of host–schistosome interactions and offer a potential mechanism by which some vaccine antigens exert their protective efficacy

Susceptibility of Selected Potato Varieties to Zebra Chip Potato Disease

Zebra chip (ZC), an emerging and serious disease of potato has caused millions of dollars in losses to the potato industry in the United States, Mexico, Central America, and New Zealand. The disease has recently been associated with a previously undescribed species of liberibacter tentatively named “Candidatus Liberibacter solanacearum” transmitted to potato by the potato psyllid, Bactericera cockerelli (Šulc). At present, applications of insecticides targeted against the potato psyllid are the only means to manage ZC. Given the low psyllid density and short inoculation access period required to induce the disease, insecticides may not act fast enough to prevent transmission of liberibacter to potato by the psyllid and development of ZC. Identification and development of ZC-resistant or tolerant varieties may offer the most efficient and sustainable way to manage this potato disease. Susceptibility of selected potato varieties to ZC was evaluated under controlled field cage conditions in 2009 and 2010 in WA by inoculating potato plants with “Ca. L. solanacearum” using infective potato psyllids and monitoring them for ZC symptom development. All potato varieties evaluated in both years of the study were determined to be very susceptible to the disease, with almost 100% of the inoculated plants developing severe ZC foliar and tuber symptoms. Potato yield in all tested varieties was significantly affected by ZC, with yield losses ranging from 49.9% to 87. 2%. Information from this research suggests that there is an urgent need to develop new potato varieties that are resistant or tolerant to this damaging potato disease