The effectiveness of recall strategies in the primary classroom to increase pupils’ self-confidence in knowing and remembering more

Studies suggest that retrieval of information from long-term memory through quizzing can improve the amount of information learnt over time. Furthermore, performance in quizzes and tests can be linked to pupil self-confidence at school. This study aimed to investigate this effect through the use of ‘quick quizzes’ in a primary school setting, investigating if recall of information through quizzes increases the amount of information learnt and self-confidence in academic ability. The study involved 165 pupils across 4 year groups, with 2 classes per year group. The intervention administered in the study involved each class starting their foundation subject lessons with a quick quiz, for a six-week unit of work. In each year group, one class completed the quizzes in a written format, with the other completing the quizzes orally. Pupil self-confidence was self-reported at the start and end of the unit of work. The results showed that there were no significant differences in the amount of information recalled between the written and oral conditions, however, more pupils from the written condition felt that the quick quizzes contributed to increasing their self-confidence in the topic. Furthermore, teachers found the quizzes to be very successful as an assessment tool in their classrooms. These findings suggest that using recall strategies such as quick quizzes can contribute to a positive classroom environment in which pupils feel self-confident in their learning and that the method of administering these quizzes should be considered for maximum benefit

Modelling the interactions between geomorphological processes and Natural Flood Management

Natural Flood Management (NFM) measures are being implemented across the UK and Europe in an effort to reduce flood impacts in a cost-effective and sustainable manner. Presently, NFM measures are often constructed without consideration of their geomorphological impact. There is also little evidence for NFM measures such as Runoff Attenuation Features (RAFs), which include leaky barriers, having an impact at larger (> 10 km2) catchment scales and for extreme events (> 100 year return period). This thesis examines both the hydrological and geomorphological effects of RAFs through; (i) morphodynamic modelling of RAFs of differing shapes, sizes and quantities at catchment scale (~41 km2) for an extreme event (120 year return period), (ii) comparison between a morphodynamic model and geomorphological processes estimated from outputs of a hydraulic model, which enables (iii) hydraulic modelling of differences in leaky barrier design. The results indicate that a RAF can be designed to increase water storage and floodplain connectivity. However, hydrologically beneficial designs can produce erosion and deposition and scour to the feature itself. These effects are all localised and at catchment scale no notable peak discharge reduction was observed. Thus relying solely on RAFs will only likely reduce localised, low magnitude flooding and future research should look to strengthening this argument alongside increasing understanding of structure failure within networks of RAFs. Qualitatively, the geomorphological outputs derived from CAESAR-Lisflood (a morphodynamic model) and HEC-RAS 2D (a hydraulic model) agreed with each other. However, methodological refinement is needed before hydraulic model outputs can be repurposed into geomorphological process estimations on a wider, national scale with little detailed validation. Overall, the HEC-RAS 2D methodology should be used to consider local problems requiring a high spatial resolution including changes in infrastructure design. CAESAR-Lisflood should be used to consider catchment dynamics and where NFM measures induce bed morphology changes

Behavior change techniques in health professional training: developing a coding tool

Health professional Continuing Professional Development (CPD) courses often aim to change practice; understanding which training techniques drive behavior change can help educators facilitate this. The 93-item Behaviour Change Technique Taxonomy (BCTT) describes behavior change techniques (BCTs) used in behavior change interventions but was not designed for understanding CPD; it is necessary to explore how best to use the BCTT in this context. This study aimed to explore the BCTs used by CPD course educators to change healthcare practice and to develop and pilot an e-tool, based on the BCTT, to enable course designers and educators to understand which BCTs are in their training. This understanding could lead to enhanced CPD and an experimental approach to assessing the benefits of including a variety of BCTs in CPD. Two psychologists, trained in using the BCTT, observed three postgraduate medical CPD courses. In Phase 1, the BCTT was used to code 26 hours of observations. An e-tool including observed BCTs was developed and used to code 35 hours of observations in Phase 2. Feedback was collected through short discussions with educators from each course. The tool was further refined in Phase 3. Thirty-seven BCTs were identified in Phase 1, a further four in Phase 2, and a further two in Phase 3. The final e-tool comprised 43 BCTs with examples of their use based on course observations to aid identification, since educators fed back that they would value an uncomplicated tool with practice-related examples. A coding tool to understand the active ingredients in health professional CPD could enable educators to maximize the impact of CPD on practice. Further work should explore whether educators themselves are able to use the tool to code their training interventions

Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study

<p>Background: Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of cardiovascular disease (CVD) and all-cause mortality among adults with T1DM. We evaluated these risks in adults with T1DM compared with the non-diabetic population in a nationwide study from Scotland and examined control of CVD risk factors in those with T1DM.</p> <p>Methods and Findings: The Scottish Care Information-Diabetes Collaboration database was used to identify all people registered with T1DM and aged ≥20 years in 2005–2007 and to provide risk factor data. Major CVD events and deaths were obtained from the national hospital admissions database and death register. The age-adjusted incidence rate ratio (IRR) for CVD and mortality in T1DM (n = 21,789) versus the non-diabetic population (3.96 million) was estimated using Poisson regression. The age-adjusted IRR for first CVD event associated with T1DM versus the non-diabetic population was higher in women (3.0: 95% CI 2.4–3.8, p<0.001) than men (2.3: 2.0–2.7, p<0.001) while the IRR for all-cause mortality associated with T1DM was comparable at 2.6 (2.2–3.0, p<0.001) in men and 2.7 (2.2–3.4, p<0.001) in women. Between 2005–2007, among individuals with T1DM, 34 of 123 deaths among 10,173 who were <40 years and 37 of 907 deaths among 12,739 who were ≥40 years had an underlying cause of death of coma or diabetic ketoacidosis. Among individuals 60–69 years, approximately three extra deaths per 100 per year occurred among men with T1DM (28.51/1,000 person years at risk), and two per 100 per year for women (17.99/1,000 person years at risk). 28% of those with T1DM were current smokers, 13% achieved target HbA1c of <7% and 37% had very poor (≥9%) glycaemic control. Among those aged ≥40, 37% had blood pressures above even conservative targets (≥140/90 mmHg) and 39% of those ≥40 years were not on a statin. Although many of these risk factors were comparable to those previously reported in other developed countries, CVD and mortality rates may not be generalizable to other countries. Limitations included lack of information on the specific insulin therapy used.</p> <p>Conclusions: Although the relative risks for CVD and total mortality associated with T1DM in this population have declined relative to earlier studies, T1DM continues to be associated with higher CVD and death rates than the non-diabetic population. Risk factor management should be improved to further reduce risk but better treatment approaches for achieving good glycaemic control are badly needed.</p&gt

Spine-like structures in Paleogene muricate planktonic foraminifera

Muricate planktonic foraminifera comprise an extinct clade that was diverse and abundant in the Paleogene oceans and are widely used in palaeoclimate research as geochemical proxy carriers for the upper oceans. Their characteristic wall texture has surface projections called “muricae” formed by upward deflection and mounding of successive layers of the test wall. The group is generally considered to have lacked “true spines”: that is, acicular calcite crystals embedded in and projecting from the test surface such as occur in many modern and some Paleogene groups. Here we present evidence from polished sections, surface wall scanning electron microscope images and test dissections, showing that radially orientated crystalline spine-like structures occur in the centre of muricae in various species of Acarinina and Morozovella and projected from the test wall in life. Their morphology and placement in the wall suggest that they evolved independently of true spines. Nevertheless, they may have served a similar range of functions as spines in modern species, including aiding buoyancy and predation and especially harbouring algal photosymbionts, the function for which we suggest they probably first evolved. Our observations strengthen the analogy between Paleogene mixed-layer-dwelling planktonic foraminifera and their modern spinose counterparts

Apparent preservation of primary foraminiferal Mg/Ca ratios and Mg-banding in recrystallized foraminifera

Trace element and δ18O values of foraminifera are widely used to reconstruct oceanic temperatures throughout the Cenozoic and beyond. Previous work evaluating the geochemistry of foraminifera with differing degrees of physical preservation have shown that Mg/Ca and δ18O paleothermometers give discrepant values in recrystallized tests, with planktonic oxygen isotopes often yielding significantly lower temperatures than Mg/Ca ratios. To study the mobility of elements during diagenesis, we performed microspatial trace element analyses in Eocene Morozovella. Element maps show that trace element banding is readily identifiable and preserved, to an extent, in texturally recrystallized tests. A reaction-diffusion model was used to test whether the preservation of Mg-banding and the decoupling of δ18O and Mg/Ca values could be the result of diffusively limited “closed-system” recrystallization. Results show that, in a closed system, internal features (such as Mg-banding) will dissipate prior to changes in bulk Mg/Ca composition, while the bulk δ18O value will typically change faster than Mg/Ca. This is observed regardless of what partitioning coefficient is used for Mg and demonstrates that the planktonic Mg/Ca proxy is more diagenetically robust than the δ18O proxy. Thus, this model can explain the observed decoupling of these two proxies. Furthermore, the preservation of intra-test Mg-banding shows potential for use in evaluating the preservation of primary Mg/Ca values and hence the accuracy of paleotemperature reconstructions

COVID-19 length of hospital stay: a systematic review and data synthesis.

BACKGROUND: The COVID-19 pandemic has placed an unprecedented strain on health systems, with rapidly increasing demand for healthcare in hospitals and intensive care units (ICUs) worldwide. As the pandemic escalates, determining the resulting needs for healthcare resources (beds, staff, equipment) has become a key priority for many countries. Projecting future demand requires estimates of how long patients with COVID-19 need different levels of hospital care. METHODS: We performed a systematic review of early evidence on length of stay (LoS) of patients with COVID-19 in hospital and in ICU. We subsequently developed a method to generate LoS distributions which combines summary statistics reported in multiple studies, accounting for differences in sample sizes. Applying this approach, we provide distributions for total hospital and ICU LoS from studies in China and elsewhere, for use by the community. RESULTS: We identified 52 studies, the majority from China (46/52). Median hospital LoS ranged from 4 to 53 days within China, and 4 to 21 days outside of China, across 45 studies. ICU LoS was reported by eight studies-four each within and outside China-with median values ranging from 6 to 12 and 4 to 19 days, respectively. Our summary distributions have a median hospital LoS of 14 (IQR 10-19) days for China, compared with 5 (IQR 3-9) days outside of China. For ICU, the summary distributions are more similar (median (IQR) of 8 (5-13) days for China and 7 (4-11) days outside of China). There was a visible difference by discharge status, with patients who were discharged alive having longer LoS than those who died during their admission, but no trend associated with study date. CONCLUSION: Patients with COVID-19 in China appeared to remain in hospital for longer than elsewhere. This may be explained by differences in criteria for admission and discharge between countries, and different timing within the pandemic. In the absence of local data, the combined summary LoS distributions provided here can be used to model bed demands for contingency planning and then updated, with the novel method presented here, as more studies with aggregated statistics emerge outside China

Revealing their true stripes: Mg/Ca banding in the Paleogene planktonic foraminifera genus Morozovella and implications for paleothermometry

The Mg/Ca ratio of foraminiferal calcite is a widely used empirical proxy for ocean temperature. Foraminiferal Mg/Ca-temperature relationships are based on extant species and are species-specific, introducing uncertainty when applying them to the fossil tests of extinct groups. Many modern species show remarkable heterogeneity in their intra-test Mg distributions, typically due to the presence of high Mg bands, which have a biological origin. Importantly, banding patterns differ between species, which could affect Mg/Ca-temperature relationships. Few studies have looked at intra-test variability in Mg/Ca ratios in extinct species of foraminifera, despite the obvious implications for paleothermometry. We used electron probe microanalysis (EPMA) to investigate intra-test Mg distributions in the fossil tests of two species of planktonic foraminifera from the extinct muricate mixed-layer-dwelling genus Morozovella, commonly used in Paleogene sea surface temperature reconstructions. Both M. aragonensis and M. crater show striking Mg banding patterns with multiple high and low Mg/Ca band pairs throughout the test wall in all chambers. The intra-test Mg variability in M. aragonensis and M. crater is similar to that in modern species widely used in paleoclimate reconstructions and banding patterns are consistent with published growth models for modern forms, albeit with subtle differences. The presence of Mg bands supports the application of Mg/Ca-palaeothermometry in extinct Morozovella species as well as the utility of EPMA for examining preservation of foraminifera tests in paleoclimatological studies. However, we emphasize the importance of rigorous assessments of inter- and intra-test Mg variability when using microanalytical techniques for foraminiferal Mg/Ca paleothermometry

Investigating the role of solvent type and microwave selective heating on the extraction of phenolic compounds from cacao (Theobroma cacao L.) pod husk

Cacao pod husk (CPH) is a primary waste in the cacao industry that contains favourable natural antioxidants based on phenolic compounds. This study reported an investigation of the effect of extraction parameters to maximise the bioactive yields of CPH extract. The preliminary extraction was focused on high total phenolic content and continued to maximise the total monomeric anthocyanin and antioxidant activity that have the potential to be applied as food additives. The solvent selection and particle size were the key parameters for extraction to reach the maximum phenolic yield (100.4 ± 0.5 mg GAE/g dw). It was confirmed that 50% (v/v) aqueous ethanol was the most appropriate solvent, either based on experimental results or Hansen Solubility parameter prediction. At the same time, the comparison of microwave and conventional heating suggested that Microwave-assisted Extraction was the best method to get high phenolic content due to its selective heating effects. The results showed that the maximum bioactive yields were 0.37 ± 0.0 mg Cy3GE/g dw of anthocyanin and 3.36 ± 0.02 mg TE/g dw of antioxidants obtained under 50 °C and 5 min extraction time. Gallic acid, catechin, epicatechin, coumaric acid and quercetin were identified in CPH extract using High-Performance Liquid Chromatography