Relación del comportamiento de la reproducción de vacas Holstein con las fluctuaciones de peso vivo.

El estudio buscaba determinar cómo influía un cambio en la precipitación y el peso vivo de las vacas sobre las variables calores, concepciones, días abiertos por encima de cien, coeficientes de gestación y ERH (eficiencia reproducctiva del hato). Se utilizó el test de Bartlett para homogeneidad de varianza y los análisis de correlación y regresión lineal simple para establecer el grado de asociación entre las variables. Igualmente se usó la prueba de homogeneidad de coeficientes de regresión para establecer comparaciones. Los resultados no indicaron influencia consistente de la precipitación pluvial sobre las variables analizadas incluyendo los cambios de peso corporal posiblemente porque las vacas no dependían totalmente del forraje para su alimentación. Mientras la precipitación, peso corporal, calores, concepciones y coeficientes de gestación mostraron comportamiento homogéneo con el test de Bartlett a través de los tres años analizados, los días abiertos por encima de 100 y el ERH mostraron cambios muy irregulares. Solamente las variables calores y coeficientes de gestación mostraron la misma tendencia durante los 3 años y se correlacionaron en forma negativa no significativa (r = menos 0.17) y positiva significativa (r = 0.33), respectivamente, con el peso corporalGanadería bovin

Los vasco-navarros ante la España, y ante los otros españoles : tres capítulos y un epílogo

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Atribución del pie de imp.: Palau, 282267Signaturizado numéricament

Nanoemulsions based on thymol-eugenol mixtures: characterization, stability and larvicidal activity against Aedes aegypti

Dengue, Zika, chikungunya and yellow fever are the most important vector-borne diseases worldwide transmitted to humans by Aedes aegypti (L.) (Diptera Culicidae). Thus, the control of this vector is of vital importance in order to avoid epidemics in tropical and neo-tropical areas. To find new and effective larvicidal formulations for control programs against mosquito populations, aqueous dispersions containing thymol and eugenol were characterized and tested against Ae. aegypti larvae. The dispersion and stabilization of thymol and eugenol in water was possible using a triblock copolymer with two lateral blocks of poly(ethylene oxide) and a central block of poly(propylene oxide), the so-called poloxamer 407, which allows obtaining oil in water (o/w) emulsion. Dynamic Light Scattering (DLS) points out that emulsions containing eugenol were in most cases monodisperse with an average apparent hydrodynamic diameter of the droplets in the 20-25 nm without destabilization after 28 months from their preparation, which plays a key role for the potential application of the studied formulations. On the other side, those emulsions containing only thymol as oilphase had higher polydispersity, suggesting a central role of eugenol in the dispersion of thymol in water. Furthermore, the combined effect of thymol and eugenol against Ae. aegypti larvae was evaluated. The nanoemulsion containing thymol as main component of the oil phase (100%) showed the lowest LC50 and the introduction of eugenol to the nanoemulsions facilitated the dispersion andstability of thymol in water, even though reducing the effectiveness of the emulsions. The findings on the larvicidal effects of the combined application of the monoterpenes tested could be considered a promising contribution to the development of botanicalderived larvicidal formulations against mosquitos.Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; ArgentinaFil: Fanucce, Micaela. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; ArgentinaFil: Fernandez Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Coviella, Carlos Eduardo. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; Españ

Continuous flow chemistry: A novel technology for the synthesis of marine drugs

Producción CientíficaIn this perspective, we showcase the benefits of continuous flow chemistry and photochemistry and how these valuable tools have contributed to the synthesis of organic scaffolds from the marine environment. These technologies have not only facilitated previously described synthetic pathways, but also opened new opportunities in the preparation of novel organic molecules with remarkable pharmacological properties which can be used in drug discovery programs.Ministerio de Ciencia e Innovación - (grants TED2021-131705B-C21 and PID2021-125909OB-I00

An accelerated closed universe

We study a model in which a closed universe with dust and quintessence matter components may look like an accelerated flat Friedmann-Robertson-Walker (FRW) universe at low redshifts. Several quantities relevant to the model are expressed in terms of observed density parameters, $\Omega_M$ and $\Omega_{\Lambda}$, and of the associated density parameter $\Omega_Q$ related to the quintessence scalar field $Q$.Comment: 11 pages. For a festschrift honoring Alberto Garcia. To appear in Gen. Rel. Gra

Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors

Despite the major role of Gag in establishing resistance of HIV-1 to protease inhibitors (PIs), very limited data are available on the total contribution of Gag residues to resistance to PIs. To identify in detail Gag residues and structural interfaces associated with the development of HIV-1 resistance to PIs, we traced viral evolution under the pressure of PIs using Gag-protease single genome sequencing and coevolution analysis of protein sequences in 4 patients treated with PIs over a 9-year period. We identified a total of 38 Gag residues correlated with the protease, 32 of which were outside Gag cleavage sites. These residues were distributed in 23 Gag-protease groups of coevolution, with the viral matrix and the capsid represented in 87% and 52% of the groups. In addition, we uncovered the distribution of Gag correlated residues in specific protein surfaces of the inner face of the viral matrix and at the Cyclophilin A binding loop of the capsid. In summary, our findings suggest a tight interdependency between Gag structural proteins and the protease during the development of resistance of HIV-1 to PIs

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

The possible out-of-season effect of beta-carotene supplementation on ovulation rate (OR), antral follicles (AFN), and total ovarian activity (TOA = OR + AFN) as related to the LH release pattern in yearling anestrous goats was evaluated. In late April, Alpine-Saanen-Nubian x Criollo goats (n = 22, 26 N) were randomly allotted to: (1) Beta-carotene (BETA; n = 10, orally supplemented with 50 mg/goat/d; 36.4 ± 1.07 kg live weight (LW), 3.5 ± 0.20 units, body condition score (BCS) or (2) Non-supplemented (CONT; n = 12, 35.2 ± 1.07 kg LW, 3.4 ± 0.2 units BCS). Upon estrus synchronization, an intensive blood sampling (6 h × 15 min) was accomplished in May for LH quantifications; response variables included (pulsatility-PULSE, time to first pulse-TTFP, amplitude-AMPL, nadir-NAD and area under the curve-AUC). Thereafter, an ultrasonography scanning was completed to assess OR and AFN. The Munro algorithm was used to quantify LH pulsatility; if significant effects of time, treatment or interaction were identified, data were compared across time. Neither LW nor BCS (p > 0.05) or even the LH (p > 0.05); PULSE (4.1 ± 0.9 pulses/6 h), NAD (0.47 ± 0.13 ng) and AUC (51.7 ± 18.6 units) differed between treatments. Nonetheless, OR (1.57 vs. 0.87 ± 0.18 units) and TOA (3.44 vs. 1.87 ± 0.45 units) escorted by a reduced TTFP (33 vs. 126 ± 31.9 min) and an increased AMPL (0.55 vs. 0.24 ± 0.9 ng), favored to the BETA supplemented group (p < 0.05), possibly through a GnRH-LH enhanced pathway and(or) a direct effect at ovarian level. Results are relevant to speed-up the out-of-season reproductive outcomes in goats while may embrace translational applications