WFC3 Instrument Science Report 2009-12 WFC3 Example Datasets

Flight-like example datasets for the WFC3 UVIS and IR channels have been constructed and are publicly available for observers to use for learning and testing WFC3 data processing and analysis software. The Datasets Simple WFC3 UVIS and IR datasets are publically available for observers to download and use for testing and becoming familiar with WFC3 calibration and analysis software. The example datasets were constructed by taking the raw FITS files for a few exposures recently obtained on-orbit as part of the WFC3 Servicing Mission Orbital Verification (SMOV) program and replacing the image portions with data from non-proprietary ground-test observations. Thus the file formats and header contents are completely flightlike and faithfully reflect what observers will get from standard pipeline processing of on-orbit science data. Details of the WFC3 file formats and contents, as well as the calibration processing performed by the calwf3 program, can be found in the WFC3 Data Handbook (Kim Quijano et al. 2009). The Data Handbook is availabe from th

The magnetic field and geometry of the oblique shock in the jet of 3C 346

We investigate the brightest regions of the kpc-scale jet in the powerful radio galaxy 3C 346, using new optical HST ACS/F606W polarimetry together with Chandra X-ray data and 14.9 GHz and 22.5 GHz VLA radio polarimetry. The jet shows a close correspondence in optical and radio morphology, while the X-ray emission shows an 0.80 +/- 0.17 kpc offset from the optical and radio peak positions. Optical and radio polarimetry show the same apparent magnetic field position angle and fractional polarization at the brightest knot, where the jet undergoes a large kink of almost 70 degrees in the optical and radio images. The apparent field direction here is well-aligned with the new jet direction, as predicted by earlier work that suggested the kink was the result of an oblique shock. We have explored models of the polarization from oblique shocks to understand the geometry of the 3C 346 jet, and find that the upstream flow is likely to be highly relativistic (0.91 +0.05 / -0.07 c), where the plane of the shock front is inclined at an angle of 51 (+/- 11) degrees to the upstream flow which is at an angle 14 (+8 / -7) degrees to our line of sight. The actual deflection angle of the jet in this case is only 22 degrees.Comment: 11 pages, 5 figures. Accepted by MNRA

Personalised therapy in follicular lymphoma - is the dial turning?

Follicular lymphoma is the most common indolent lymphoma accounting for approximately 20%–25% of all new non-Hodgkin lymphoma diagnoses in western countries. Whilst outcomes are mostly favorable, the spectrum of clinical phenotypes includes high-risk groups with significantly inferior outcomes. This review discusses recent updates in risk stratification and treatment approaches from upfront treatment for limited and advanced stage follicular lymphoma to the growing options for relapsed, refractory disease with perspectives on how to approach this from a personalized lens. Notable gaps remain on how one can precisely and prospectively select optimal treatment for patients based on varying risks, with an anticipation that an increased understanding of the biology of these different phenotypes and increasing refinement of imaging- and biomarker-based tools will, in time, allow these gaps to be closed

Optogenetic stimulation probes with single-neuron resolution based on organic LEDs monolithically integrated on CMOS

Funding: This work was supported in part by the Defense Advanced Research Projects Agency (DARPA) under contract N6600117C4012, by the National Institutes of Health under grant U01NS090596, by the Leverhulme Trust (RPG-2017-231) and by the Alexander von Humboldt Stiftung (Humboldt-Professorship to M.C.G.). This work was performed in part at the Columbia Nano Initiative cleanroom facility, at the CUNY Advanced Science Research Center Nanofabrication Facility, and at the Singh Center for Nanotechnology, part of the National Nanotechnology Coordinated Infrastructure Program, which is supported by the National Science Foundation grant NNCI-2025608. C.-K.M. acknowledges funding from the European Commission through a Marie-Skłodowska Curie Individual Fellowship (101029807).The use of optogenetic stimulation to evoke neuronal activity in targeted neural populations—enabled by opsins with fast kinetics, high sensitivity and cell-type and subcellular specificity—is a powerful tool in neuroscience. However, to interface with the opsins, deep-brain light delivery systems are required that match the scale of the spatial and temporal control offered by the molecular actuators. Here we show that organic light-emitting diodes can be combined with complementary metal–oxide–semiconductor technology to create bright, actively multiplexed emissive elements. We create implantable shanks in which 1,024 individually addressable organic light-emitting diode pixels with a 24.5 µm pitch are integrated with active complementary metal–oxide–semiconductor drive and control circuitry. This integration is enabled by controlled electrode conditioning, monolithic deposition of the organic light-emitting diodes and optimized thin-film encapsulation. The resulting probes can be used to access brain regions as deep as 5 mm and selectively activate individual neurons with millisecond-level precision in mice.Publisher PDFPeer reviewe

Constraining the optical emission from the double pulsar system J0737-3039

We present the first optical observations of the unique system J0737-3039 (composed of two pulsars, hereafter PSR-A and PSR-B). Ultra-deep optical observations, performed with the High Resolution Camera of the Advanced Camera for Surveys on board the Hubble Space Telescope could not detect any optical emission from the system down to m_F435W=27.0 and m_F606W=28.3. The estimated optical flux limits are used to constrain the three-component (two thermal and one non-thermal) model recently proposed to reproduce the XMM-Newton X-ray spectrum. They suggest the presence of a break at low energies in the non-thermal power law component of PSR-A and are compatible with the expected black-body emission from the PSR-B surface. The corresponding efficiency of the optical emission from PSR-A's magnetosphere would be comparable to that of other Myr-old pulsars, thus suggesting that this parameter may not dramatically evolve over a time-scale of a few Myr.Comment: 16 pages, 3 figures, ApJ accepte

Efficacy and safety of dasatinib vs. Imatinib in Latin american subpopulation from the dasision trial in patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP)

sem informação100120th Congress of European-Hematology-Associationsem informaçã

The Massive Star Content of NGC 3603

We investigate the massive star content of NGC 3603, the closest known giant H II region. We have obtained spectra of 26 stars in the central cluster using the Baade 6.5-m telescope (Magellan I). Of these 26 stars, 16 had no previous spectroscopy. We also obtained photometry of all of the stars with previous or new spectroscopy, primarily using archival HST ACS/HRC images. We use these data to derive an improved distance to the cluster, and to construct an H-R diagram for discussing the masses and ages of the massive star content of this cluster.Comment: Accepted by the Astronomical Journal. This revision updates the coordinates in Table 1 by (-0.18sec, +0.2") to place them on the UCAC2 syste