3,318 research outputs found
Entire solutions of hydrodynamical equations with exponential dissipation
We consider a modification of the three-dimensional Navier--Stokes equations
and other hydrodynamical evolution equations with space-periodic initial
conditions in which the usual Laplacian of the dissipation operator is replaced
by an operator whose Fourier symbol grows exponentially as \ue ^{|k|/\kd} at
high wavenumbers . Using estimates in suitable classes of analytic
functions, we show that the solutions with initially finite energy become
immediately entire in the space variables and that the Fourier coefficients
decay faster than \ue ^{-C(k/\kd) \ln (|k|/\kd)} for any . The
same result holds for the one-dimensional Burgers equation with exponential
dissipation but can be improved: heuristic arguments and very precise
simulations, analyzed by the method of asymptotic extrapolation of van der
Hoeven, indicate that the leading-order asymptotics is precisely of the above
form with . The same behavior with a universal constant
is conjectured for the Navier--Stokes equations with exponential
dissipation in any space dimension. This universality prevents the strong
growth of intermittency in the far dissipation range which is obtained for
ordinary Navier--Stokes turbulence. Possible applications to improved spectral
simulations are briefly discussed.Comment: 29 pages, 3 figures, Comm. Math. Phys., in pres
The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review.
Agents that augment cerebral blood flow (CBF) could be potential treatments for vascular cognitive impairment. Phosphodiesterase-5 inhibitors are vasodilating drugs established in the treatment of erectile dysfunction (ED) and pulmonary hypertension. We reviewed published data on the effects of phosphodiesterase-5 inhibitors on CBF in adult humans. A systematic review according to PRISMA guidelines was performed. Embase, Medline and Cochrane Library Trials databases were searched. Sixteen studies with 353 participants in total were retrieved. Studies included healthy volunteers and patients with migraine, ED, type 2 diabetes, stroke, pulmonary hypertension, Becker muscular dystrophy and subarachnoid haemorrhage. Most studies used middle cerebral artery flow velocity to estimate CBF. Few studies employed direct measurements of tissue perfusion. Resting CBF velocity was unaffected by phosphodiesterase-5 inhibitors, but cerebrovascular regulation was improved in ED, pulmonary hypertension, diabetes, Becker's and a group of healthy volunteers. This evidence suggests that phosphodiesterase-5 inhibitors improve responsiveness of the cerebral vasculature, particularly in disease states associated with an impaired endothelial dilatory response. This supports the potential therapeutic use of phosphodiesterase-5 inhibitors in vascular cognitive impairment where CBF is reduced. Further studies with better resolution of deep CBF are warranted. The review is registered on the PROSPERO database (registration number CRD42016029668)
The Nature of the Molecular Environment within 5 pc of the Galactic Center
We present a detailed study of molecular gas in the central 10pc of the
Galaxy through spectral line observations of four rotation inversion
transitions of NH3 made with the VLA. Updated line widths and NH3(1,1)
opacities are presented, and temperatures, column densities, and masses are
derived. We examine the impact of Sgr A East on molecular material at the
Galactic center and find that there is no evidence that the expansion of this
shell has moved a significant amount of the 50 km/s GMC. The western streamer,
however, shows strong indications that it is composed of material swept-up by
the expansion of Sgr A East. Using the mass and kinematics of the western
streamer, we calculate an energy of E=(2-9)x10^{51} ergs for the progenitor
explosion and conclude that Sgr A East was most likely produced by a single
supernova. The temperature structure of molecular gas in the central ~20pc is
also analyzed in detail. We find that molecular gas has a ``two-temperature''
structure similar to that measured by Huttemeister et al. (2003a) on larger
scales. The largest observed line ratios, however, cannot be understood in
terms of a two-temperature model, and most likely result from absorption of
NH3(3,3) emission by cool surface layers of clouds. By comparing the observed
NH3 (6,6)-to-(3,3) line ratios, we disentangle three distinct molecular
features within a projected distance of 2pc from Sgr A*. Gas associated with
the highest line ratios shows kinematic signatures of both rotation and
expansion. The southern streamer shows no significant velocity gradients and
does not appear to be directly associated with either the circumnuclear disk or
the nucleus. The paper concludes with a discussion of the line-of-sight
arrangement of the main features in the central 10pc.Comment: 51 pages, 16 figures, accepted for publication in ApJ. Due to size
limitations, some of the images have been cut from this version. A complete,
color PS or PDF version can be downloaded from
http://www.astro.columbia.edu/~herrnstein/NH3/paper
Constraining Disk Parameters of Be Stars using Narrowband H-alpha Interferometry with the NPOI
Interferometric observations of two well-known Be stars, gamma Cas and phi
Per, were collected and analyzed to determine the spatial characteristics of
their circumstellar regions. The observations were obtained using the Navy
Prototype Optical Interferometer equipped with custom-made narrowband filters.
The filters isolate the H-alpha emission line from the nearby continuum
radiation, which results in an increased contrast between the interferometric
signature due to the H-alpha-emitting circumstellar region and the central
star. Because the narrowband filters do not significantly attenuate the
continuum radiation at wavelengths 50 nm or more away from the line, the
interferometric signal in the H-alpha channel is calibrated with respect to the
continuum channels. The observations used in this study represent the highest
spatial resolution measurements of the H-alpha-emitting regions of Be stars
obtained to date. These observations allow us to demonstrate for the first time
that the intensity distribution in the circumstellar region of a Be star cannot
be represented by uniform disk or ring-like structures, whereas a Gaussian
intensity distribution appears to be fully consistent with our observations.Comment: 23 pages, 14 figures, accepted for publication in A
CT imaging of ascaris lumbricoides
A 37-year-old man was referred to the department of internal medicine for chronic fever, asthenia and loss of weight. He had no relevant medical history but reported frequent travels to Africa. Abdominal-CT study with contrast agent injection and oral digestive opacification was performed and revealed pleuroperitoneal and pericardial effusions with multiple mediastinal and mesenteric lymphadenopathies. Bronchoalveolar lavage and sputum expectoration analyses demonstrated systemic tuberculosis
Novel set-up for low-disturbance sampling of volatile and non-volatile compounds from plant roots
Eilers E, Pauls G, Rillig MC, Hansson BS, Hilker M, Reinecke A. Novel set-up for low-disturbance sampling of volatile and non-volatile compounds from plant roots. Journal of Chemical Ecology. 2016;41(3):253-266.Most studies on rhizosphere chemicals are carried out in substrate-free set-ups or in artificial substrates using sampling methods that require an air flow and may thus cause disturbance to the rhizosphere. Our study aimed to develop a simplified and inexpensive system that allows analysis of rhizosphere chemicals at experimentally less disturbed conditions. We designed a mesocosm in which volatile rhizosphere chemicals were sampled passively (by diffusion) without air- and water flow on polydimethylsiloxane-(PDMS) tubes. Dandelion (Taraxacum sect. ruderalia) was used as model plant; roots were left undamaged. Fifteen volatiles were retrieved from the sorptive material by thermal desorption for analysis by gas chromatography/mass spectrometry (GC/MS). Furthermore, three sugars were collected from the rhizosphere substrate by aqueous extraction and derivatized prior to GC/MS analysis. In order to study how the quantity of detected rhizosphere compounds depends on the type of soil or substrate, we determined the matrix-dependent recovery of synthetic rhizosphere chemicals. Furthermore, we compared sorption of volatiles on PDMS tubes with and without direct contact to the substrate. The results show that the newly designed mesocosm is suitable for low-invasive extraction of volatile and non-volatile compounds from rhizospheres. We further highlight how strongly the type of substrate and contact of PDMS tubes to the substrate affect the detectability of compounds from rhizospheres
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette\u27s Syndrome and OCD
OBJECTIVE: Obsessive-compulsive disorder (OCD) and Tourette\u27s syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette\u27s syndrome and OCD. METHOD: The authors conducted a GWAS in 2,723 cases (1,310 with OCD, 834 with Tourette\u27s syndrome, 579 with OCD plus Tourette\u27s syndrome/chronic tics), 5,667 ancestry-matched controls, and 290 OCD parent-child trios. GWAS summary statistics were examined for enrichment of functional variants associated with gene expression levels in brain regions. Polygenic score analyses were conducted to investigate the genetic architecture within and across the two disorders. RESULTS: Although no individual single-nucleotide polymorphisms (SNPs) achieved genome-wide significance, the GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders. Polygenic score analyses identified a significant polygenic component for OCD (p=2x10(-4)), predicting 3.2% of the phenotypic variance in an independent data set. In contrast, Tourette\u27s syndrome had a smaller, nonsignificant polygenic component, predicting only 0.6% of the phenotypic variance (p=0.06). No significant polygenic signal was detected across the two disorders, although the sample is likely underpowered to detect a modest shared signal. Furthermore, the OCD polygenic signal was significantly attenuated when cases with both OCD and co-occurring Tourette\u27s syndrome/chronic tics were included in the analysis (p=0.01). CONCLUSIONS: Previous work has shown that Tourette\u27s syndrome and OCD have some degree of shared genetic variation. However, the data from this study suggest that there are also distinct components to the genetic architectures of these two disorders. Furthermore, OCD with co-occurring Tourette\u27s syndrome/chronic tics may have different underlying genetic susceptibility compared with OCD alone
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