4,117 research outputs found
Mind Over Matter: A Qualitative Examination of the Coping Resources Used by Women with Cancer
Aim: This exploratory study investigates the coping resources used by six women diagnosed with cancer.
Objective: The purpose of this study was to provide these women with the opportunity to discuss their cancer experiences along with the specific coping methods they found to be helpful throughout their journey.
Methods: The participants, ranging in age from 25 to 63, completed a background questionnaire, followed by either a semi-structured interview (n=3) or an interview via written response (n=3).
Results: Several key coping methods were described as being helpful to these women, and these methods fell into three major categories: intrapersonal, interpersonal, and extrapersonal coping resources. Although each of these resource categories had a direct influence on overall well-being itself, the interpersonal and extrapersonal resources also influenced the intrapersonal category, offering an alternate means by which they could influence overall well-being. These findings highlight the many coping resources used by these women when navigating their cancer journey
Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC
Abstract Expression of the cellular prion protein (PrPC) is crucial for the development of prion diseases. Amino acid changes in PrPC or a reduced amount of PrPC may modulate disease resistance. The relative abundance of C1, a natural α-cleavage fragment of PrPC, was previously found to be associated with a resistant PRNP genotype in sheep. Goats are another small ruminant where classical scrapie susceptibility is under strong genetic control. In this study, we assessed PrPC in goats for the existence of similar associations between PrPC fragments and genotype. Brain tissue homogenates from scrapie-free goats with wild type PRNP or polymorphisms (I142M, H143R, N146S, or Q222K) were deglycosylated prior to immunoblot for assessment of the relative abundance of the C1 fragment of PrPC. The presence of K222 or S146 alleles demonstrated significantly different relative levels of C1 compared to that observed in wild type goats, which suggests that the genotype association with C1 is neither unique to sheep nor exclusive to the ovine Q171R dimorphism
Performance of a multigap RPC prototype for the LHCb muon system
Several technologies are under consideration for the muon system of the LHCb experiment. Resistive Plate Chambers (RPCs) are one of the favourite candidates for the outer areas where the particle fluxes are expected to be at most some kHz/cm/sup 2/. This work describes the results obtained with a multigap RPC prototype under various beam conditions at the CERN facilities. (9 refs)
Phylogeny and Evolution of Selected Primates as Determined by Sequences of the Δ-Globin Locus and 5âČ Flanking Regions
We studied phylogenetic relationships of 39 primate species using sequences of the Δ-globin gene. For 13 species, we also included flanking sequences 5âČ of this locus. Parsimony analyses support the association of tarsiers with the anthropoids. Our analysis of New World monkeys supports the model in which the callitrichines form a clade with Aotus, Cebus, and Saimiri, with Cebus and Saimiri being sister taxa. However, analysis of the 5âČ flanking sequences did not support grouping the atelines with Callicebus and the pitheciins. Our data support the classification of platyrrhines into three families, Cebidae (consisting of Cebus, Saimiri, Aotus, and the callitrichines; Atelidaeâthe atelines; and Pitheciidae âCallicebus and the pithiciins. The strepsirhines form well-defined lemuroid and lorisoid clades, with the cheirogaleids (dwarf and mouse lemurs) and Daubentonia (aye-aye) in the lemuroids, and the aye-aye being the most anciently derived. These results support the hypothesis that nonhuman primates of Madagascar descended from a single lineage. Local molecular clock calculations indicate that the divergence of lemuroid and lorisoid lineages, and the earliest diversification of lemuroids, occurred during the Eocene. The divergence of major lorisoid lineages was probably considerably more recent, possibly near the MioceneâOligocene boundary. Within hominoids some estimated dates differ somewhat from those found with more extensive noncoding sequences in the ÎČ-globin cluster.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44561/1/10764_2004_Article_425562.pd
Two Rare Magnetic Cataclysmic Variables with Extreme Cyclotron Features Identified in the Sloan Digital Sky Survey
Two newly identified magnetic cataclysmic variables discovered in the Sloan
Digital Sky Survey (SDSS), SDSSJ155331.12+551614.5 and SDSSJ132411.57+032050.5,
have spectra showing highly prominent, narrow, strongly polarized cyclotron
humps with amplitudes that vary on orbital periods of 4.39 and 2.6 hrs,
respectively. In the former, the spacing of the humps indicates the 3rd and 4th
harmonics in a magnetic field of ~60 MG. The narrowness of the cyclotron
features and the lack of strong emission lines imply very low temperature
plasmas and very low accretion rates, so that the accreting area is heated by
particle collisions rather than accretion shocks. The detection of rare systems
like these exemplifies the ability of the SDSS to find the lowest accretion
rate close binaries.Comment: Accepted for publication in the Astrophysical Journal, vol. 583,
February 1, 2003; slight revisions and additions in response to referee's
comments; 17 pages, 6 figures, AASTeX v4.
The Time-Domain Spectroscopic Survey: Understanding the Optically Variable Sky with SEQUELS in SDSS-III
The Time-Domain Spectroscopic Survey (TDSS) is an SDSS-IV eBOSS subproject
primarily aimed at obtaining identification spectra of ~220,000
optically-variable objects systematically selected from SDSS/Pan-STARRS1
multi-epoch imaging. We present a preview of the science enabled by TDSS, based
on TDSS spectra taken over ~320 deg^2 of sky as part of the SEQUELS survey in
SDSS-III, which is in part a pilot survey for eBOSS in SDSS-IV. Using the
15,746 TDSS-selected single-epoch spectra of photometrically variable objects
in SEQUELS, we determine the demographics of our variability-selected sample,
and investigate the unique spectral characteristics inherent in samples
selected by variability. We show that variability-based selection of quasars
complements color-based selection by selecting additional redder quasars, and
mitigates redshift biases to produce a smooth quasar redshift distribution over
a wide range of redshifts. The resulting quasar sample contains systematically
higher fractions of blazars and broad absorption line quasars than from
color-selected samples. Similarly, we show that M-dwarfs in the TDSS-selected
stellar sample have systematically higher chromospheric active fractions than
the underlying M-dwarf population, based on their H-alpha emission. TDSS also
contains a large number of RR Lyrae and eclipsing binary stars with
main-sequence colors, including a few composite-spectrum binaries. Finally, our
visual inspection of TDSS spectra uncovers a significant number of peculiar
spectra, and we highlight a few cases of these interesting objects. With a
factor of ~15 more spectra, the main TDSS survey in SDSS-IV will leverage the
lessons learned from these early results for a variety of time-domain science
applications.Comment: 17 pages, 14 figures, submitted to Ap
New Low Accretion-Rate Magnetic Binary Systems and their Significance for the Evolution of Cataclysmic Variables
Discoveries of two new white dwarf plus M star binaries with striking optical
cyclotron emission features from the Sloan Digital Sky Survey (SDSS) brings to
six the total number of X-ray faint, magnetic accretion binaries that accrete
at rates < 10^{-13} Msun/yr, or <1% of the values normally encountered in
cataclysmic variables. This fact, coupled with donor stars that underfill their
Roche lobes and very cool white dwarfs, brand the binaries as post
common-envelope systems whose orbits have not yet decayed to the point of
Roche-lobe contact. They are pre-magnetic CVs, or pre-Polars. The systems
exhibit spin/orbit synchronism and apparently accrete by efficient capture of
the stellar wind from the secondary star, a process that has been dubbed a
``magnetic siphon''. Because of this, period evolution of the binaries will
occur solely by gravitational radiation, which is very slow for periods >3 hr.
Optical surveys for the cyclotron harmonics appear to be the only means of
discovery, so the space density of pre-Polars could rival that of Polars, and
the binaries provide an important channel of progenitors (in addition to the
asynchronous Intermediate Polars). Both physical and SDSS observational
selection effects are identified that may help to explain the clumping of all
six systems in a narrow range of magnetic field strength around 60 MG.Comment: 25 pages, 13 figures, Accepted to Ap
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Cataclysmic Variables from Sloan Digital Sky Survey. IV. The Fourth Year (2003)
This paper continues the series presenting cataclysmic variables identified during the fourth year (2003) of the Sloan Digital Sky Survey. We describe 44 close binary systems, of which 12 are the previously known systems EN Cet, EG Cnc, V844 Her, GG Leo, Leo 7, CY UMa, DV UMa, EK UMa, EV UMa, UMa 8, EUVE J0854+390, and RX J0859.1+0537 and 32 are new cataclysmic variables. As in the previous papers, the positions, colors, and spectra of all 44 systems are shown, along with follow-up spectroscopic, photometric, and/or polarimetric observations of 15 of the new systems. The new objects include one eclipsing system, eight with prominent He II emission (of which two are confirmed new polars), and 12 systems showing features of the underlying stars. Our spectropolarimetry also confirms EUVE J0854+390 as a polar
Two More Candidate AM Canum Venaticorum (AM CVn) Binaries from the Sloan Digital Sky Survey
AM CVn systems are a select group of ultracompact binaries with the shortest
orbital periods of any known binary subclass; mass-transfer is likely from a
low-mass (partially-)degenerate secondary onto a white dwarf primary, driven by
gravitational radiation. In the past few years, the Sloan Digital Sky Survey
(SDSS) has provided five new AM CVns. Here we report on two further candidates
selected from more recent SDSS data. SDSS J1208+3550 is similar to the earlier
SDSS discoveries, recognized as an AM CVn via its distinctive spectrum which is
dominated by helium emission. From the expanded SDSS Data Release 6 (DR6)
spectroscopic area, we provide an updated surface density estimate for such AM
CVns of order 10^{-3.1} to 10^{-2.5} per deg^2 for 15<g<20.5. In addition, we
present another new candidate AM CVn, SDSS J2047+0008, that was discovered in
the course of followup of SDSS-II supernova candidates. It shows nova-like
outbursts in multi-epoch imaging data; in contrast to the other SDSS AM CVn
discoveries, its (outburst) spectrum is dominated by helium absorption lines,
reminiscent of KL Dra and 2003aw. The variability selection of SDSS J2047+0008
from the 300 deg^2 of SDSS Stripe 82 presages further AM CVn discoveries in
future deep, multicolor, and time-domain surveys such as LSST. The new
additions bring the total SDSS yield to seven AM CVns thus far, a substantial
contribution to this rare subclass, versus the dozen previously known.Comment: 19 pages, 5 figures, 1 table; submitted to A
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