Residential patterns in the nineteenth century city : Kingston upon Hull, 1851

Studies of residential patterns have tended to concentrate on cities in modern societies at a similar stage of advanced industrial development. Those studies which have been carried out in less advanced societies, however, suggest that the forces behind residential differentiation vary with the nature of society itself. The three factors of social rank, family status and migrant status have been identified as major dimensions of differentiation within cities, but at a less advanced stage of development these factors are often measured in terms of different criteria, and show differing degrees of interdependence, particularly between the social rank and family status axes.Nineteenth century Britain presents an interesting example of a society in the transition stage from a pre-industrial to a modern form of organisation. Available evidence suggests the importance of a social rank criterion based on subjective rather than purely economic definitions of social status, and the differing economic circumstances between strata suggest possible links between family status and social rank. Using Hull as a case study, and the 1851 census enumerators' books as a source of data, factor analysis techniques have been used to try to define this pattern of differentiation more precisely.The main dimensions of residential differentiation are shown to be consistent with the patterns found elsewhere, although the composition of these factors contrasts markedly with the twentieth century situation, due to the specific conditions of the period. Social rank, in particular, illustrates the dichotomy within society between employers and the employed, and migrant status reflects the specific situation of Irish immigrants. An oblique solution supports the idea that social rank and family status show a marked degree of interdependence in this context. The results have clear implications for the study of nineteenth century society, and also contribute to a general theory of urban residential patterns

Detection of Amazon Forest Degradation Caused by Land Use Changes

Field and satellite optical methods for estimation of chlorophyll content were applied in three study sites of the Ecuadorian Amazon rainforest. Those sites represent a wide range of land use disturbance in secondary and pristine lowland rainforest. The first field method is based on transmittance from the SPAD-502 chlorophyll meter index, the second field method is based on reflectance measurements collected by a spectroradiometer, and the third method estimates chlorophyll content from the PROSPECT radiative transfer model. For the first method, seven models that account for a wide range of vegetation species showed similar average leaf chlorophyll contents until 80 units of SPAD-502. An average of the results of these models was computed and used as ground truth from where a generalized second-order polynomial model was created. For the second method, five chlorophyll indices based on reflectance measurements provided similar chlorophyll content estimations for all SPAD range (15–95 units). The third method estimates chlorophyll content based on the inversion process of the PROSPECT model. The satellite methods estimate vegetation indices sensitive to chlorophyll content from space. All methods have shown to be an alternative approach to detect forest degradation at local and regional levels caused by forest disturbances and land use changes

Key drivers of sustainable construction

The construction of any building / project can have a detrimental impact on a local, regional and international environment. Thus, concern for our environs has led to the concept of ‘sustainable development’ and in turn ‘sustainable construction’. Construction companies in many countries are under pressure to align their processes with such an ideology. Pressure from Government legislation and other stakeholder groups have acted as a catalyst for the evolution of the sustainable movement. In construction, the concept of ‘supply-chain-management’ has acted as a catalyst for a deeper analysis of sustainability issues within the procurement process. This paper discusses research undertaken into one such supply chain in an Irish construction company. The results show some attempt to employ sustainable construction practice, but that this drive was relatively small in relation to what can be achieved overall in sustainability terms. It was also found that most of the sustainable approaches adopted by the different supply-chain groups are in relation to issues like planning/development acts, environmental impact statements, waste management and efficient use of resources, while, only a few suppliers were found to be concerned with the issue of energy efficiency

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study.

Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD). The location of the SNP in the major histocompatibility complex class II (MHC-II) locus implicates regulation of antigen presentation as a potential mechanism by which immune responses link genetic susceptibility to environmental factors in conferring lifetime risk for PD.MethodsFor immunophenotyping, blood cells from 81 subjects were analyzed by qRT-PCR and flow cytometry. A case-control study was performed on a separate cohort of 962 subjects to determine association of pesticide exposure and the SNP with risk of PD.ResultsHomozygosity for G at this SNP was associated with heightened baseline expression and inducibility of MHC class II molecules in B cells and monocytes from peripheral blood of healthy controls and PD patients. In addition, exposure to a commonly used class of insecticide, pyrethroids, synergized with the risk conferred by this SNP (OR = 2.48, p = 0.007), thereby identifying a novel gene-environment interaction that promotes risk for PD via alterations in immune responses.ConclusionsIn sum, these novel findings suggest that the MHC-II locus may increase susceptibility to PD through presentation of pathogenic, immunodominant antigens and/or a shift toward a more pro-inflammatory CD4+ T cell response in response to specific environmental exposures, such as pyrethroid exposure through genetic or epigenetic mechanisms that modulate MHC-II gene expression

Longitudinal evaluation of cognitive functioning in young children with type 1 diabetes over 18 months

OBJECTIVE: Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T1D. METHODS: 144 children with T1D (mean HbA1c: 7.9%) and 70 age-matched healthy controls (mean age both groups 8.5 years; median diabetes duration 3.9 yrs; mean age of onset 4.1 yrs) underwent neuropsychological testing at baseline and after 18-months of follow-up. We hypothesized that group differences observed at baseline would be more pronounced after 18 months, particularly in those T1D patients with greatest exposure to glycemic extremes. RESULTS: Cognitive domain scores did not differ between groups at the 18 month testing session and did not change differently between groups over the follow-up period. However, within the T1D group, a history of diabetic ketoacidosis (DKA) was correlated with lower Verbal IQ and greater hyperglycemia exposure (HbA1c area under the curve) was inversely correlated to executive functions test performance. In addition, those with a history of both types of exposure performed most poorly on measures of executive function. CONCLUSIONS: The subtle cognitive differences between T1D children and nondiabetic controls observed at baseline were not observed 18 months later. Within the T1D group, as at baseline, relationships between cognition (VIQ and executive functions) and glycemic variables (chronic hyperglycemia and DKA history) were evident. Continued longitudinal study of this T1D cohort and their carefully matched healthy comparison group is planned

Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients with Oesophageal Adenocarcinoma

Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current treatment modalities and has a strong link to obesity. To better elucidate the role of visceral adiposity in this disease state, a full metabolic profile combined with analysis of secreted pro-inflammatory cytokines, metabolites, and lipid profiles were assessed in human ex vivo adipose tissue explants from obese and non-obese OAC patients. These data were then related to extensive clinical data including obesity status, metabolic dysfunction, previous treatment exposure, and tumour regression grades. Real-time energy metabolism profiles were assessed using the seahorse technology. Adipose explant conditioned media was screened using multiplex ELISA to assess secreted levels of 54 pro-inflammatory mediators. Targeted secreted metabolite and lipid profiles were analysed using Ultra-High-Performance Liquid Chromatography coupled with Mass Spectrometry. Adipose tissue explants and matched clinical data were collected from OAC patients (n = 32). Compared to visceral fat from non-obese patients (n = 16), visceral fat explants from obese OAC patients (n = 16) had significantly elevated oxidative phosphorylation metabolism profiles and an increase in Eotaxin-3, IL-17A, IL-17D, IL-3, MCP-1, and MDC and altered secretions of glutamine associated metabolites. Adipose explants from patients with metabolic dysfunction correlated with increased oxidative phosphorylation metabolism, and increases in IL-5, IL-7, SAA, VEGF-C, triacylglycerides, and metabolites compared with metabolically healthy patients. Adipose explants generated from patients who had previously received neo-adjuvant chemotherapy (n = 14) showed elevated secretions of pro-inflammatory mediators, IL-12p40, IL-1α, IL-22, and TNF-β and a decreased expression of triacylglycerides. Furthermore, decreased secreted levels of triacylglycerides were also observed in the adipose secretome of patients who received the chemotherapy-only regimen FLOT compared with patients who received no neo-adjuvant treatment or chemo-radiotherapy regimen CROSS. For those patients who showed the poorest response to currently available treatments, their adipose tissue was associated with higher glycolytic metabolism compared to patients who had good treatment responses. This study demonstrates that the adipose secretome in OAC patients is enriched with mediators that could prime the tumour microenvironment to aid tumour progression and attenuate responses to conventional cancer treatments, an effect which appears to be augmented by obesity and metabolic dysfunction and exposure to different treatment regimes

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner