Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations.

"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population. Quantile-specific offspring-parent regression slopes (βOP) were estimated by quantile regression for 6227 offspring-parent pairs. Quantile-specific heritability (h2), estimated by 2βOP/(1 + rspouse), decreased 0.0047 ± 0.0007 (P = 2.9 × 10-14) for each one-percent decrement in fasting triglyceride concentrations, i.e., h2 ± SE were: 0.428 ± 0.059, 0.230 ± 0.030, 0.111 ± 0.015, 0.050 ± 0.016, and 0.033 ± 0.010 at the 90th, 75th, 50th, 25th, and 10th percentiles of the triglyceride distribution, respectively. Consistent with quantile-dependent expressivity, 11 drug studies report smaller genotype differences at lower (post-treatment) than higher (pre-treatment) triglyceride concentrations. This meant genotype-specific triglyceride changes could not move in parallel when triglycerides were decreased pharmacologically, so that subtracting pre-treatment from post-treatment triglyceride levels necessarily created a greater triglyceride decrease for the genotype with a higher pre-treatment value (purported precision-medicine genetic markers). In addition, sixty-five purported gene-environment interactions were found to be potentially attributable to triglyceride's quantile-dependent expressivity, including gene-adiposity (APOA5, APOB, APOE, GCKR, IRS-1, LPL, MTHFR, PCSK9, PNPLA3, PPARγ2), gene-exercise (APOA1, APOA2, LPL), gene-diet (APOA5, APOE, INSIG2, LPL, MYB, NXPH1, PER2, TNFA), gene-alcohol (ALDH2, APOA5, APOC3, CETP, LPL), gene-smoking (APOC3, CYBA, LPL, USF1), gene-pregnancy (LPL), and gene-insulin resistance interactions (APOE, LPL)

Pyrolysis of brominated feedstock plastic in a fluidised bed reactor

Fire retarded high impact polystyrene has been pyrolysed using a fluidised bed reactor with a sand bed. The yield and composition of the products have been investigated in relation to fluidised bed temperature. The bromine distribution between the products and a detailed analysis of the oils using GC-FID/ECD, GC-MS, FT-ir, and size exclusion chromatography has been carried out. It was found that the majority of the bromine transfers to the pyrolysis oil and the antimony was detected in both the oil and the char. Oil made up over 89.9% of the pyrolysis products. Over 30% of the oil consisted of benzene, toluene, ethylbenzene, styrene and cumene. The pyrolysis gases were mainly hydrocarbons in the C1-C4 range but some HBr and Br2 was detected

Justification Patterns for OWL DL Ontologies

For debugging OWL-DL ontologies, natural language explanations of inconsistencies and undesirable entailments are of great help. From such explanations, ontology developers can learn why an ontology gives rise to specific entailments. Unfortunately, commonly used tableaux-based reasoning services do not provide a basis for such explanations, since they rely on a refutation proof strategy and normalising transformations that are difficult for human ontology editors to understand. For this reason, we investigate the use of automatically generated justifications for entailments (i.e., minimal sets of axioms from the ontology that cause entailments to hold). We show that such justifications fall into a manageable number of patterns, which can be used as a basis for generating natural language explanations by associating each justification pattern with a rhetorical pattern in natural language

Promoting hydrogen production and minimizing catalyst deactivation from the pyrolysis-catalytic steam reforming of biomass on nanosized NiZnAlOx catalysts

Hydrogen production from the thermochemical conversion of biomass was carried out with nano-sized NiZnAlOx catalysts using a two-stage fixed bed reactor system. The gases derived from the pyrolysis of wood sawdust in the first stage were catalytically steam reformed in the second stage. The NiZnAlOx catalysts were synthesized by a co-precipitation method with different Ni molar fractions (5, 10, 15, 25 and 35%) and a constant Zn:Al molar ratio of 1:4. The catalysts were characterized by a wide range of techniques, including N2 adsorption, SEM, XRD, TEM and temperature-programmed oxidation (TPO) and reduction (TPR). Fine metal particles of size around 10–11 nm were obtained and the catalysts had high stability characteristics, which improved the dispersion of active centers during the reaction and promoted the performance of the catalysts. The yield of gas was increased from 49.3 to 74.8 wt.%, and the volumetric concentration of hydrogen was increased from 34.7 to 48.1 vol.%, when the amount of Ni loading was increased from 5 to 35%. Meanwhile, the CH4 fraction decreased from 10.2 to 0.2 vol.% and the C2–C4 fraction was reduced from 2.4 vol.% to 0.0 vol.%. During the reaction, the crystal size of all catalysts was successfully maintained at around 10–11 nm with lowered catalyst coke formation, (particularly for the 35NiZn4Al catalyst where negligible coke was found) and additionally no obvious catalyst sintering was detected. The efficient production of hydrogen from the thermochemical conversion of renewable biomass indicates that it is a promising sustainable route to generate hydrogen from biomass using the NiZnAl metal oxide catalyst prepared in this work via a two-stage reaction system

Evidence That Obesity Risk Factor Potencies Are Weight Dependent, a Phenomenon That May Explain Accelerated Weight Gain in Western Societies

We have shown that individuals at the highest percentiles of the body mass index (BMI) distribution (i.e., most overweight) experience greater increases in body weight from sedentary lifestyle than those from the lowest percentiles. The purpose of the current analyses was to assess whether recent, accelerated increases in obesity could potentially be due to increased vulnerability to obesity risk factors as the population has become more overweight.Quantile regression was used to compare BMI population percentiles to obesity risk factors (lower education, diets characterized by high-meat/low-fruit content, parental adiposity) in two independent samples of men (N(1) = 3,513, N(2) = 11,365) and women (N(1) = 15,809, N(2) = 10,159). The samples were subsets of the National Walkers' (Study 1) and Runners' (Study 2) Health Studies whose physical activities fell short of nationally recommended activity levels. The data were adjusted for age, race, and any residual effects of physical activity. The regression slopes for BMI vs. education, diet, and family history became progressively stronger from the lowest (e.g., 5(th), 6(th)…) to the highest (e.g., …, 94(th), 95(th)) BMI percentiles. Compared to the 10(th) BMI percentile, their effects on the 90(th) BMI percentile were: 1) 2.7- to 8.6-fold greater in women and 2.0- to 2.4-fold greater in men for education; 2) 3.6- to 4.8-fold greater in women and 1.7- to 2.7-fold greater in men for diet; and 3) 2.0- to 2.6-fold greater in women and 1.7-fold greater in men for family history.Thus we propose risk factors that produce little weight gain in lean individuals may become more potent with increasing adiposity. This leads us to hypothesize that an individual's obesity is itself a major component of their obesogenic environment, and that, the cycle of weight gain and increased sensitivity to obesity risk factors may partly explain recent increases in obesity in western societies

Catalytic steam reforming of volatiles released via pyrolysis of wood sawdust for hydrogen-rich gas production on Fe–Zn/Al2O3 nanocatalysts

Thermo-chemical processing of biomass is a promising alternative to produce renewable hydrogen as a clean fuel or renewable syngas for a sustainable chemical industry. However, the fast deactivation of catalysts due to coke formation and sintering limits the application of catalytic thermo-chemical processing in the emerging bio-refining industry. In this research, Fe-Zn/Al2O3 nanocatalysts have been prepared for the production of hydrogen through pyrolysis catalytic reforming of wood sawdust. Through characterization, it was found that Fe and Zn were well distributed on the surface with a narrow particle size. During the reactions, the yield of hydrogen increased with the increase of Zn content, as Zn is an efficient metal promoter for enhancing the performance of the Fe active site in the reaction. The 20% Fe/Al2O3 catalyst with Zn/Al ratio of 1:1 showed the best performance in the process in relation to the hydrogen production and resistance to coke formation on the surface of the reacted catalyst. All the catalysts showed ultra-high stability during the process and nearly no sintering were observed on the used catalysts. Therefore, the nanocatalysts prepared from natural-abundant and low-cost metals in this work have promising catalytic properties (high metal dispersion and stability) to produce H2-rich syngas with optimal H2/CO ratio from the thermo-chemical process of biomass

Hydrogen from waste plastics by way of pyrolysis-gasification

A screw kiln continuous reaction system was used to investigate the production of hydrogen from a representative waste plastic (polypropylene). The reactor system consisted of two stages, with pyrolysis of the plastic in the firststage screw kiln, followed by catalytic gasification of the product pyrolysis gases in the second stage. Two catalysts (a laboratory prepared Ni-Mg-Al catalyst and a commercial nickel catalyst) were used and the process conditions of gasification temperature and water injection rate were investigated. The results showed that the introduction of catalyst into the gasification stage dramatically increased the hydrogen production. The gas and hydrogen production and amount of reacted water per hour were increased with the increase of the gasification temperature from 600 to 900°C for both the Ni-Mg-Al and the commercial nickel catalysts. The rate of water injection was also shown to be critical for hydrogen production. The maximum hydrogen produced was 52% of the maximum theoretical hydrogen available in the polypropylene, representing 22̇38 g of hydrogen per 100 g polypropylene, obtained with the Ni-Mg- Al catalyst, at 800°C gasification temperature and with 28̇46 g/h water injection rate

Rethinking the Political Future: An Alternative to the Ethno-Sectarian Division of Iraq

In the coming year, the political leadership in Iraq will need to make a final determination as to whether they are going to structure the state of Iraq as a federal state with ethnically heterogeneous provinces, a loose federal state with ethnically defined provinces or regions, or whether they are going to divide the state into three new states based on ethno-sectarian lines. A number of prominent American law makers and foreign policy shapers have strongly advocated for the soft, and sometimes hard, partition of Iraq — either through the creation of a loose federal structure based on ethno-sectarian lines, or through its outright partition. These commentators have prophesized that the ethno-sectarian division of Iraq “may soon be all we have left. In fact, the ethno-sectarian division of Iraq is fraught with logistical infeasibilities and dangers that threaten to compound the issues facing the people of Iraq instead of solving them. The political solution rests not on a return to failed approaches of division and entrenched conflict, but rather on the construction of a viable modern federal state that promotes unity, political compromise, and consensus building. To address the question of whether the future of Iraq rests with ethno-sectarian division or with multi-ethnic federalism, this Article first addresses the ideas behind ethno-sectarian division and describes the most prominent plans for the division of Iraq along ethno-sectarian lines. This Article then critiques such a division of Iraq by: (1) identifying the overwhelming lack of popular support for such a division; (2) exposing the practical and political difficulties of dividing a state as diverse and heterogeneous as Iraq; (3) discussing the likelihood that ethno-sectarian division will increase violent conflict; (4) highlighting the lessons of prior ethno-sectarian divisionist attempts; (5) noting insurmountable constitutional hurdles; and (6) setting out the significant signs of recent progress and cooperation in the Iraqi political framework

Pyrolysis-Catalytic-Dry Reforming of Waste Plastics and Mixed Waste Plastics for Syngas Production

The CO2 dry reforming of various types of waste plastics (LDPE, HDPE, PS, PET, and PP) and a simulated mixture of the different waste plastics was investigated over a Ni–Co–Al catalyst using a two-stage reactor. The first stage pyrolyzed the plastics, and the second stage involved catalytic-dry reforming of the product pyrolysis gases with CO2. The introduction of CO2 without a catalyst markedly increased the dry reforming reaction and significantly improved the production of H2/CO synthesis gas (syngas). The introduction of the Ni–Co–Al catalyst further significantly improved the production of syngas. LDPE produced the highest yield of syngas at 154.7 mmolsyngas g–1plastic from the pyrolysis-catalytic-dry reforming process. The order of syngas production for the different plastics was LDPE < HDPE < PP < PS < PET. The syngas yield from the processing of the simulated waste plastic mixture was 148.6 7 mmolsyngas g–1plastic which reflected the high content of the linear polyalkene plastics (LDPE, HDPE, PP) in the simulated waste plastic mixture

Fast pyrolysis of halogenated plastics recovered from waste computers

The disposal of waste computers is an issue that is gaining increasing interest around the world. In this paper, results from the fast pyrolysis in a fluidized bed reactor of three different waste computer monitor casings composed of mainly acrylonitrile-butadiene-styrene (ABS) copolymer and two different waste computer body casings composed of mostly poly(vinyl chloride) (PVC) type polymers are presented. Preliminary characterization of the waste plastics was investigated using coupled thermogravimetric analysis-Fourier transform infrared spectrometry (TGA-FT-IR). The results showed that the plastics decomposed in two stages. For the ABS-containing monitor casings, aromatic and aliphatic material were released in the first and second stages. The PVC-containing computer body casing samples showed a first-stage evolution of HCl and a second stage evolution of aromatic and aliphatic material and further HCl. In addition, each of the five plastics was fast-pyrolyzed in a laboratory-scale fluidized bed reactor at 500 °C. The fluidized bed pyrolysis led to the conversion of most of the plastics to pyrolysis oil, although the two PVC computer body cases produced large quantities of HCl. The pyrolysis oils were characterized by GC-MS and it was found that they were chemically very heterogeneous and contained a wide range of aliphatic, aromatic, halogenated, oxygenated, and nitrogenated compounds