HIV/AIDS and Community Action: Now I know my Rights!

yesThis briefing presents research on a small project on the use of a rights-based approach by groups of People Living with HIV/AIDS (PLWHA) in Northern Tanzania. It concludes that with support the groups were able to use the 2008 HIV/AIDS act to claim their rights to tackle stigma and access ARV medication. However, the fulfillment of these rights is limited by chronic poverty and structural weakness of the state

How men and women learn about sex: multi-generational perspectives on insufficient preparedness and prevailing gender norms in Scotland

Attitudes towards sexual health and relationships are learned from a young age, and there is an ongoing need for innovative and comprehensive approaches to sex education that keep pace with rapidly changing contexts of people’s lives. We used thematic analysis of data from two qualitative studies in Scotland to explore learning contexts from a multi-generational perspective, as well as the influence of different socio-cultural factors on provision, access to and experience of sex education. The importance, but inadequacy, of school as a source of learning, was a persistent theme over time. Participants’ strategies to address perceived gaps in knowledge included experience, conversations, vicarious and online learning. Gender and age differences emerged, with younger participants more likely to go online for information, and prevailing gender norms shaping attitudes and behaviours across both study groups. Participants who identified as gay, lesbian or bisexual described feeling particularly unprepared for sex and relationships due to the narrow, heteronormative content received. Although schools continue to be a common source of information, it appears that they fail to equip young people for their post-school sexual life-course. We recommend the mandatory provision of comprehensive, positive, inclusive and skills-based learning to improve people’s chances of forming and building healthy, positive relationships across the lifespan

Perceived Links between Playing Surfaces and Injury: A Worldwide Study of Elite Association Football Players

This is an Open Access Article. It is published by Springer under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Background: Injuries in association football (soccer) are debilitating for players and can also be detrimental to the success of a team or club. The type or condition of a playing surface has been empirically linked to injuries, yet results are inconclusive. The overall purpose of this study was to analyse elite football players’ perceived links between playing surfaces and injury from a worldwide cohort of players. The results of this study can help to inform areas for future playing surface research aimed at trying to alleviate user concerns and meet user (i.e. the player) needs. Methods: Quantitative data were collected from 1129 players across the globe to address the aim of this study. Results: Ninety-one percent of players believed the type or condition of a surface could increase injury risk. Abrasive injuries, along with soreness and pain, were perceived to be greater on artificial turf. Surface type, surface properties and age were all potential risk factors identified by the players and linked to the playing surfaces. Conclusions: The results identified three areas where future research should be focussed to help develop surfaces that alleviate user concerns and meet user (i.e. player) needs: (i) current reporting of soreness, pain or fatigue as injuries, (ii) contribution of surface properties to injury; and (iii) surface experience of players from different countries differentiates their views of injury risk

Elite football players' perceptions of football turf and natural grass surface properties.

AbstractGiven the global spread of football (soccer) there are substantial differences in the playing surfaces used between FIFA member associations. This paper contains results from the second part of a study on elite football players’ perceptions of playing surfaces from across the globe. Using a questionnaire, which was developed based on an initial qualitative study, elite players’ perceptions of differences in surface properties between natural and artificial (football) turf were examined. In total, 1129 elite footballers, representing 43 countries across six FIFA confederations completed the questionnaire. Exploratory analysis of overall responses revealed that the players had strong opinions with regards to surface properties when directly comparing natural and football turf. In particular, a higher proportion of players stated that football turf was “Too hard/Harder”, “More level”, “More abrasive” and had “Less grip” compared to natural grass. The results also showed that overall players’ perceptions of surface properties, between natural grass and football turf were dependent on their experience of different playing surfaces during their junior and senior careers, in particular, the variability within football turf pitches

Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections

We have developed cross-genotype and genotype-specific quantitative reverse-transcription PCR (qRT-PCR) assays to detect and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi infections. Our cross-genotype assays are reliable, repeatable and generate counts that correlate strongly (R(2)s > 90%) with counts expected from blood smears. Our genotype-specific assays can distinguish and quantify different stages of genetically distinct parasite clones (genotypes) in mixed infections and are as sensitive as our cross-genotype assays. Using these assays we show that gametocyte density and gametocyte sex ratios vary during infections for two genetically distinct parasite lines (genotypes) and present the first data to reveal how sex ratio is affected when each genotype experiences competition in mixed-genotype infections. Successful infection of mosquito vectors depends on both gametocyte density and their sex ratio and we discuss the implications of competition in genetically diverse infections for transmission success

Gametocytes: insights gained during a decade of molecular monitoring

In vertebrate hosts, malaria parasites produce specialized male and female sexual stages (gametocytes). Soon after being taken up by a mosquito, gametocytes rapidly produce gametes and, once mated, they infect their vector and can be transmitted to new hosts. Despite being the parasite stages that were first identified (over a century ago), gametocytes have remained elusive, and basic questions remain concerning their biology. However, the postgenomic era has substantiated information on the specialized molecular machinery of gametocytogenesis and expedited the development of molecular tools to detect and quantify gametocytes. The application of such highly sensitive and specific tools has opened up novel approaches and provided new insights into gametocyte biology. Here, we review the discoveries made during the past decade, highlight unanswered questions and suggest new directions

Overmoulding of electronics for end of life recovery

With the increasing use of electronic control systems in automotive applications, the environments in which they are required to operate are becoming evermore demanding. For improved functionality and to reduce the number of interconnections it is desirable to place the electronic control units (ECUs) as close as possible to the sensors and actuators they interact with, and they can increasingly be found mounted on engine, transmission and chassis components. The electronics are therefore exposed to high/low temperatures, high humidity, vibration and corrosive fluids. In order to protect the electronics and maintain reliability in safety critical areas, great lengths are taken to mount the devices in ways that will prevent the ingress of moisture, cushion shocks and dissipate heat. Potting of electrical devices with thermosetting polymers has been a commonplace method to install a protective layer over the circuit assemblies, which are often mounted in separate boxes within the vehicle. However, with the drive to reduce vehicle weight and increase recyclability, there has been much interest in the use of overmoulding with thermoplastic polymers, not only to provide protection, but to enable the electronics to be mounted into a structural component of the vehicle thereby saving space and weight and eliminating a level of packaging. While this has been shown to be a practical way forward in terms of reliability, the recyclability of the thermoplastic polymer is compromised by the intermixed electronics that are hard to separate economically

Data on the Lignosus rhinocerotis water soluble sclerotial extract affecting intracellular calcium level in rat dorsal root ganglion cells

The data in this article contain supporting evidence for the research manuscript entitled “Bronchodilator effects of Lignosus rhinocerotis extract on rat isolated airways is linked to the blockage of calcium entry” by Lee et al. (2018) [1]. The data were obtained by calcium imaging technique with fluorescent calcium indicator dyes, Fura 2-AM, to visualize calcium ion movement in the rat dorsal ganglion (DRG) cells. The effects of L. rhinocerotis cold water extract (CWE1) on intracellular calcium levels in the DRG cells were presented. Keywords: Lignosus rhinocerotis, Medicinal mushroom, Bronchodilators, Calcium dynamic

Ecology Drives the Worldwide Distribution of Human Diseases

Identifying the factors underlying the origin and maintenance of the latitudinal diversity gradient is a central problem in ecology, but no consensus has emerged on which processes might generate this broad pattern. Interestingly, the vast majority of studies exploring the gradient have focused on free-living organisms, ignoring parasitic and infectious disease (PID) species. Here, we address the influence of environmental factors on the biological diversity of human pathogens and their global spatial organization. Using generalized linear multivariate models and Monte Carlo simulations, we conducted a series of comparative analyses to test the hypothesis that human PIDs exhibit the same global patterns of distribution as other taxonomic groups. We found a significant negative relationship between latitude and PID species richness, and a nested spatial organization, i.e., the accumulation of PID species with latitude, over large spatial scales. Additionally, our results show that climatic factors are of primary importance in explaining the link between latitude and the spatial pattern of human pathogens. Based on our findings, we propose that the global latitudinal species diversity gradient might be generated in large part by biotic interactions, providing strong support for the idea that current estimates of species diversity are substantially underestimated. When parasites and pathogens are included, estimates of total species diversity may increase by more than an order of magnitude