The problems of offenders with mental disorders: A plurality of perspectives within a single mental health care organisation

Managers, doctors, nurses, occupational therapists, social workers, psychologists, unqualified staff and service users were interviewed for a qualitative study of risk management and rehabilitation in an inner city medium secure forensic mental health care unit. Different professional orientations to service user problems were identified. Doctors focused primarily on the diagnosis of mental disorder, which they managed mainly through pharmaceutical interventions. Psychologists were principally concerned with personal factors, for example service user insight into their biographical history. Occupational therapists concentrated mainly on daily living skills, and social workers on post-discharge living arrangements. Some front line nurses, held accountable for security lapses, adopted a criminogenic approach. Service users were more likely than professionals to understand their needs in terms of their wider life circumstances. These differences are explored qualitatively in relation to four models of crossdisciplinary relationships: monoprofessional self-organisation combined with restricted communication; hermeneutic reaching out to other perspectives; the establishment of interdisciplinary sub-systems; and transdisciplinary merger. Relationships between professions working in this unit, as portrayed in qualitative interviews, corresponded mainly to the first model of monoprofessional self-organisation. Reasons for restricted crossdisciplinary understanding, particularly the wide power/status differences between the medical and other professions, and between staff and patients, are discussed

Leishmaniasis: new approaches to disease control.

The leishmaniases afflict the world's poorest populations. Among the two million new cases each year in the 88 countries where the disease is endemic (fig 1), it is estimated that 80% earn less than $2 a day. Human infections with Leishmania protozoan parasites, transmitted via the bite of a sandfly, cause visceral, cutaneous, or mucocutaneous leishmaniasis. The global burden of leishmaniasis has remained stable for some years, causing 2.4 million disability adjusted life years (DALYs) lost and 59 000 deaths in 2001. Neglected by researchers and funding agencies, leishmaniasis control strategies have varied little for decades, but in recent years there have been exciting advances in diagnosis, treatment, and prevention. These include an immunochromatographic dipstick for diagnosing visceral leishmaniasis; the licensing of miltefosine, the first oral drug for visceral leishmaniasis; and evidence that the incidence of zoonotic visceral leishmaniasis in children can be reduced by providing dogs with deltamethrin collars. There is also hope that the first leishmaniasis vaccine will become available within a decade. Here we review these developments and identify priorities for research

Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus

Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to the established role of muscarinic receptors. In the hippocampus, where cholinergic involvement in learning and memory is particularly well documented, 7 nicotinic acetylcholine receptor subunits (7 nAChRs) are highly expressed, but their precise ultrastructural localization has not been determined. Here, we describe the results of immunogold labeling of serial ultrathin sections through stratum radiatum of area CA1 in the rat. Using both anti-7 nAChR immunolabeling and -bungarotoxin binding, we find that 7 nAChRs are present at nearly all synapses in CA1 stratum radiatum, with immunolabeling present at both presynaptic and postsynaptic elements. Morphological considerations and double immunolabeling indicate that GABAergic as well as glutamatergic synapses bear 7 nAChRs, at densities approaching those observed for glutamate receptors in CA1 stratum radiatum. Postsynaptically, 7 nAChRs often are distributed at dendritic spines in a perisynaptic annulus. In the postsynaptic cytoplasm, immunolabeling is associated with spine apparatus and other membranous structures, suggesting that 7 nAChRs may undergo dynamic regulation, with insertion into the synapse and subsequent internalization. The widespread and substantial expression of 7 nAChRs at synapses in the hippocampus is consistent with an important role in mediating and/or modulating synaptic transmission, plasticity, and neurodegeneration

Theory and design of quantum cascade lasers in (111) n-type Si/SiGe

Although most work towards the realization of group IV quantum cascade lasers (QCLs) has focused on valence band transitions, there are many desirable properties associated with the conduction band. We show that the commonly cited shortcomings of n-type Si/SiGe heterostructures can be overcome by moving to the (111) growth direction. Specifically, a large band offset and low effective mass are achievable and subband degeneracy is preserved. We predict net gain up to lattice temperatures of 90 K in a bound-to-continuum QCL with a double-metal waveguide, and show that a Ge interdiffusion length of at least 8 Å across interfaces is tolerable

A laterally-fused N-heterocyclic carbene framework from polysubstituted aminoimidazo[5,1-b]oxazol-6-ium salts

A polysubstituted 3-aminoimidazo[5,1-b]oxazol-6-ium framework has been accessed from a new nitrenoid reagent by a two-step ynamide annulation and imidazolium ring-formation sequence. Metalation with Au(I), Cu(I) and Ir(I) at the C2 position provides an L-shaped NHC ligand scaffold that has been validated in gold-catalysed alkyne hydration and arylative cyclisation reactions

Contamination of short GRBs by giant magnetar flares: significance of downwards revision in distance to SGR 1806-20

We highlight how the downward revision in the distance to the star cluster associated with SGR1806-20 by Bibby et al. reconciles the apparent low contamination of BATSE short GRBs by intense flares from extragalactic magnetars without recourse to modifying the frequency of one such flare per 30 years per Milky Way galaxy. We also discuss the variety in progenitor initial masses of magnetars based upon cluster ages, ranging from ~50 Msun for SGR 1806-20 and 1E 1647-455 in Westerlund 1 to ~15 Msun for SGR 1900+14 and presumably 1E 1841-045 if it originated from one of the massive RSG clusters #2 or #3

Clues to Nuclear Star Cluster Formation from Edge-on Spirals

We find 9 nuclear cluster candidates in a sample of 14 edge-on, late-type galaxies observed with HST/ACS. These clusters have magnitudes (M_I ~ -11) and sizes (r_eff ~ 3pc) similar to those found in previous studies of face-on, late-type spirals and dE galaxies. However, three of the nuclear clusters are significantly flattened and show evidence for multiple, coincident structural components. The elongations of these three clusters are aligned to within 10 degrees of the galaxies' major axes. Structurally, the flattened clusters are well fit by a combination of a spheroid and a disk or ring. The nuclear cluster disks/rings have F606W-F814W (~V-I) colors 0.3-0.6 magnitudes bluer than the spheroid components, suggesting that the stars in these components have ages < 1 Gyr. In NGC 4244, the nearest of the nuclear clusters, we further constrain the stellar populations and provide a lower limit on the dynamical mass via spectroscopy. We also present tentative evidence that another of the nuclear clusters (in NGC 4206) may also host a supermassive black hole. Based on our observational results we propose an in situ formation mechanism for nuclear clusters in which stars form episodically in compact nuclear disks, and then lose angular momentum or heat vertically to form an older spheroidal structure. We estimate the period between star formation episodes to be 0.5 Gyr and discuss possible mechanisms for tranforming the disk-like components into spheroids. We also note the connection between our objects and massive globular clusters (e.g. $\omega$ Cen), UCDs, and SMBHs. (Abridged)Comment: Accepted for publication in the A

EDUCATIONAL AWARENESS OF FACTORS REDUCING MATERNAL MORTALITY IN RURAL COMMUNITIES IN OGUN STATE NIGERIA

The study aimed at educational awareness of non–medical factors associated with maternal mortality reduction and to proffer policy guidelines for informed policy intervention. We analyzed secondary data from the 2010 Covenant University project on non-medical determinants of maternal mortality in Ado-Odo/Ota Local Government Area, Ogun State. The study employed an informant approach questionnaire design, and information on maternal mortality was recorded from 360 eligible respondents which constituted the sample size and descriptive statistics and regression analysis were further applied. The study shows among others that majority of the respondents married between the ages of 25 and 44 with a proportion of 64.2 percent. As for the deceased spouse, an overwhelming proportion of the deceased spouses got married below 30 years (64.2%). Employment status of respondents showed that those not working registered 22.5 percent and their deceased counter parts in the same working status accounts for higher proportion (39.9). The highest level of education attained by majority of the respondents interviewed was secondary education (48.1%), followed by primary education (28.6%). For the education of their deceased spouses, it was observed that 50% of them had only primary education followed by those who attained secondary school (26.7%) and those who never went to school (19.7%). The educational attainment of the deceased was very poor when compared to their husbands in all categories. Distance is a very important factor in the utilization of health facility. Slightly above three-fourths of respondents (75.2%) have to travel 6 km and beyond to access or avail themselves this facility. Treatment costs was mainly born by the respondents (49.7%) and spouse’s relatives and friends (36.7%) Regression analysis results showed that ‘person who pays the treatment costs’ (p=0.003) and ‘place of consultation’ (p=0.000) were non-medical significant factors influencing maternal mortality reduction. The study recommends empowering and improving the status of women through better education and paid out of home employment in order to reduce maternal mortality and prompt better Safe Motherhood Initiative, Also providing educational awareness of non–medical factors associated with maternal mortality to men is likely to herald positive decision and better treatment to women from men especially during the journey of pregnancy and child birth

Greater priming for previously distracting information in young than older adults when suppression is ruled out

The use of previously distracting information on memory tests with indirect instructions is usually age-equivalent, while young adults typically show greater explicit memory for such information. This could reflect qualitatively distinct initial processing (encoding) of distracting information by younger and older adults, but could also be caused by greater suppression of such information by younger adults on tasks with indirect instructions. In Experiment 1, young and older adults read stories containing distracting words, which they ignored, before studying a list of words containing previously distracting items for a free recall task. Half the participants were informed of the presence of previously distracting items in the study list prior to recall (direct instruction), and half were not (indirect instruction). Recall of previously distracting words was age-equivalent in the indirect condition, but young adults recalled more distracting words in the direct condition. In Experiment 2, participants performed the continuous identification with recognition task, which captures a measure of perceptual priming and recognition on each trial, and is immune to suppression. Priming and recognition of previously distracting words was greater in younger than older adults, suggesting that the young engage in more successful suppression of previously distracting information on tasks in which its relevance is not overtly signaled