Prevalence of incidental breast cancer and precursor lesions in autopsy studies: A systematic review and meta-analysis

Abstract Background Autopsy studies demonstrate the prevalence pool of incidental breast cancer in the population, but estimates are uncertain due to small numbers in any primary study. We aimed to conduct a systematic review of autopsy studies to estimate the prevalence of incidental breast cancer and precursors. Methods Relevant articles were identified through searching PubMed and Embase from inception up to April 2016, and backward and forward citations. We included autopsy studies of women with no history of breast pathology, which included systematic histological examination of at least one breast, and which allowed calculation of the prevalence of incidental breast cancer or precursor lesions. Data were pooled using logistic regression models with random intercepts (non-linear mixed models). Results We included 13 studies from 1948 to 2010, contributing 2363 autopsies with 99 cases of incidental cancer or precursor lesions. More thorough histological examination (≥20 histological sections) was a strong predictor of incidental in-situ cancer and atypical hyperplasia (OR = 126·8 and 21·3 respectively, p < 0·001), but not invasive cancer (OR = 1·1, p = 0·75). The estimated mean prevalence of incidental cancer or precursor lesion was 19·5% (0·85% invasive cancer + 8·9% in-situ cancer + 9·8% atypical hyperplasia). Conclusion Our systematic review in ten countries over six decades found that incidental detection of cancer in situ and breast cancer precursors is common in women not known to have breast disease during life. The large prevalence pool of undetected cancer in-situ and atypical hyperplasia in these autopsy studies suggests screening programs should be cautious about introducing more sensitive tests that may increase detection of these lesions

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

New approaches to treat bacterial infections are badly needed to address the increasing problem of antibiotic resistance. This study explores phosphonium-functionalized block copolymer micelles as intrinsically antibacterial polymer assemblies. Phosphonium cations with varying alkyl lengths were conjugated to the terminus of a poly(ethylene oxide)− polycaprolactone block copolymer, and the phosphonium-functionalized block copolymers were self-assembled to form micelles in aqueous solution. The size, morphology, and ζ -potential of the assemblies were studied, and their abilities to kill Escherichia coli and Staphylococcus aureus were evaluated. It was found that the minimum bactericidal concentration depended on the phosphonium alkyl chain length, and different trends were observed for Gram-negative and Gram-positive bacteria. The most active assemblies exhibited no hemolysis of red blood cells above the bactericidal concentrations, indicating that they can selectively disrupt the membranes of bacteria. Furthermore, it was possible to encapsulate and release the antibiotic tetracycline using the assemblies, providing a potential multimechanistic approach to bacterial killing

transformations in the nuclear and bioenergy sectors in Sweden, Brazil, and the United States

Most of the controversies surrounding how to structure climate change mitigation and adaptation – including financing, what counts as action, and how to measure progress against uncertain goals – have technological change as an underlying assumption. Technological transformation is at the heart of mitigation in the energy system, and technological change (cultivars and management) will be a prime contributor to mitigation and adaptation in agriculture and water. Therefore, the issue of governing the diffusion of GEC- related technology is critically important. The standard analyses that assume we just need to “get the prices right” are insufficient in a world where markets are at best imperfect and equitable well-being is as much a goal as efficiency. Our research examines the ways in technological change is guided by such governance factors as governments (regulation and policy), firms with existing expertise and infrastructure, international and national needs for security, innovation networks, and leadership. We will illustrate the determinative nature of these governance factors through case studies of two major energy technologies – nuclear power and biofuels – in three countries – Brazil, Sweden, and the United States. Primary data comes from interviews with policymakers and firm managers who have been involved in these changes in the three countries. Open-ended and structured questions about a range of driving or enabling factors allow us to establish one or more configurations of factors that can inform the governance of future technological change related to mitigation and serve as the basis for further research into technological change related to adaptation

Job spells, employer spells, and wage returns to tenure

We show that the distinction between job spells and employer spells matters for returns to tenure. Employer spells encompass between-job wage movements linked to promotions or demotions while job spells don't. Using a 1% sample of the British workforce over the period 1975-2010, we find that a significant proportion of the return to employer tenure arises due to job changes within employer spells. Conditional on tenure with employer, the return to job tenure is negative. This suggests that any positive effects of job-specific human capital on wage growth within jobs are outweighed by the effects of job changes within firms

Initial MLU Predicts the Relative Efficacy of Two Grammatical Treatments in Preschoolers With Specific Language Impairments

Purpose—We sought to confirm predictions based on past findings that pre-treatment mean length of utterance (MLU) would predict which of two grammatical treatments would best facilitate generalized and maintained grammatical development in preschoolers with specific language impairment (SLI). Method—The participants were 57 preschoolers with specific language impairment (SLI). A randomized group experiment was used. The two grammatical treatments were Broad Target Recasts (BTR) and Milieu Language Teaching (MLT). MLU was assessed at Time 1 in two conversational language samples. Growth rate of productive grammar was quantified using growth curve modeling on the Index of Productive Syntax (IPSyn) from two conversational language samples at each of 6 measurement periods. Results—Predictions were confirmed for children with initially low MLU, but not for children with initially high MLUs. MLT facilitated growth of grammar better than BTR in children who were initially in Brown’s stage I. Effects maintained 5 months after treatment ended

Fast ion transport in quasisymmetric equilibria in the presence of a resonant Alfv\'{e}nic perturbation

Significant progress has been made in designing magnetic fields that provide excellent confinement of the guiding enter trajectories of alpha particles using quasisymmetry (QS). Given the reduction in this transport channel, we assess the impact of resonant Alfv\'{e}n eigenmodes (AEs) on the guiding center motion. The AE amplitudes are chosen to be consistent with experimental measurements and large-scale simulations. We evaluate the drift resonance condition, phase-space island width, and island overlap criterion for quasisymmetric configurations. Kinetic Poincar\'{e} plots elucidate features of the transport, including stiff transport above a critical perturbation amplitude. Our analysis highlights key departures from the AE-driven transport in tokamaks, such as the avoidance of phase-space island overlap in quasihelical configurations and the enhanced transport due to wide phase-space islands in low magnetic shear configurations. In configurations that are closer to QS, with QS deviations $\delta B/B_0 \lesssim 10^{-3}$, the transport is primarily driven by the AE, while configurations that are further from QS, $\delta B/B_0 \sim 10^{-2}$, experience significant transport due to the QS-breaking fields in addition to the AE

Initial MLU Predicts the Relative Efficacy of Two Grammatical Treatments in Preschoolers With Specific Language Impairments

Purpose—We sought to confirm predictions based on past findings that pre-treatment mean length of utterance (MLU) would predict which of two grammatical treatments would best facilitate generalized and maintained grammatical development in preschoolers with specific language impairment (SLI). Method—The participants were 57 preschoolers with specific language impairment (SLI). A randomized group experiment was used. The two grammatical treatments were Broad Target Recasts (BTR) and Milieu Language Teaching (MLT). MLU was assessed at Time 1 in two conversational language samples. Growth rate of productive grammar was quantified using growth curve modeling on the Index of Productive Syntax (IPSyn) from two conversational language samples at each of 6 measurement periods. Results—Predictions were confirmed for children with initially low MLU, but not for children with initially high MLUs. MLT facilitated growth of grammar better than BTR in children who were initially in Brown’s stage I. Effects maintained 5 months after treatment ended

Survival in Soviet Gulags: A Secondary Analysis

One of the most common book series on the subject of Soviet Gulags is Evgenia Ginzburg’s “Journey into the Whirlwind” and “Within the Whirlwind.” This paper will use secondary analysis from anthology works with stories similar to Ginzburg\u27s in combination with the works of several other authors like Anne Applebaum (2011) and Geith and Jolluck (2011). It shall also examine extensively Raphaël Lemkin’s definition of genocide and how it fits to what happened in the Gulags. It shall be argued why certain situations that occurred within the Gulags fit this definition. It will also explore the intimate details and lives of the Repressed. It will clarify vividly some of the social psychological and life experiences they faced in the Gulags and what coping mechanisms they used to survive them