50,510 research outputs found
Access to and Affordability of Care in Massachusetts as of Fall 2008: Geographic and Racial/Ethnic Differences
Based on a fall 2008 survey, compares access to and affordability of health care, including prescription drugs and dental care, for adults by geography and race/ethnicity. Explores factors behind unmet needs and financial burdens from healthcare costs
Different types of X-ray bursts from GRS 1915+105 and their origin
We report the X-ray observations of the Galactic X-ray transient source GRS
1915+105 with the PPCs of the Indian X-ray Astronomy Experiment(IXAE) onboard
the Indian satellite IRS-P3 during 1997 June - August, which have revealed the
presence of four types of intense X-ray bursts. All the observed bursts have a
slow exponential rise, a sharp linear decay, and they can broadly be put in two
classes: irregular and quasi-regular bursts in one class, and regular bursts in
another class. The regular bursts are found to have two distinct time scales
and they persist over extended durations. There is a strong correlation between
the preceding quiescent time and the burst duration for the quasi-regular and
irregular bursts. No such correlation is found for the regular bursts. The
ratio of average flux during the burst time to the average flux during the
quiescent phase is high and variable for the quasi- regular and irregular
bursts while it is low and constant for the regular bursts. We suggest that the
peculiar bursts that we have seen are charact- eristic of the change of state
of the source. The source can switch back and forth between the low-hard state
and the high-soft state near critical accretion rates in a very short time
scale. A test of the model is presented using the publicly available 13-60 keV
RXTE/PCA data for irregular and regular bursts concurrent with our
observations.Comment: 13 pages, 12 figures, Accepted in APJ, emulateapj style use
Fermi distribution of semicalssical non-eqilibrium Fermi states
When a classical device suddenly perturbs a degenerate Fermi gas a
semiclassical non-equilibrium Fermi state arises. Semiclassical Fermi states
are characterized by a Fermi energy or Fermi momentum that slowly depends on
space or/and time. We show that the Fermi distribution of a semiclassical Fermi
state has a universal nature. It is described by Airy functions regardless of
the details of the perturbation. In this letter we also give a general
discussion of coherent Fermi states
Calibration of quasi-static aberrations in exoplanet direct-imaging instruments with a Zernike phase-mask sensor
Context. Several exoplanet direct imaging instruments will soon be in
operation. They use an extreme adaptive optics (XAO) system to correct the
atmospheric turbulence and provide a highly-corrected beam to a near-infrared
(NIR) coronagraph for starlight suppression. The performance of the coronagraph
is however limited by the non-common path aberrations (NCPA) due to the
differential wavefront errors existing between the visible XAO sensing path and
the NIR science path, leading to residual speckles in the coronagraphic image.
Aims. Several approaches have been developed in the past few years to
accurately calibrate the NCPA, correct the quasi-static speckles and allow the
observation of exoplanets at least 1e6 fainter than their host star. We propose
an approach based on the Zernike phase-contrast method for the measurements of
the NCPA between the optical path seen by the visible XAO wavefront sensor and
that seen by the near-IR coronagraph. Methods. This approach uses a focal plane
phase mask of size {\lambda}/D, where {\lambda} and D denote the wavelength and
the telescope aperture diameter, respectively, to measure the quasi-static
aberrations in the upstream pupil plane by encoding them into intensity
variations in the downstream pupil image. We develop a rigorous formalism,
leading to highly accurate measurement of the NCPA, in a quasi-linear way
during the observation. Results. For a static phase map of standard deviation
44 nm rms at {\lambda} = 1.625 {\mu}m (0.026 {\lambda}), we estimate a possible
reduction of the chromatic NCPA by a factor ranging from 3 to 10 in the
presence of AO residuals compared with the expected performance of a typical
current-generation system. This would allow a reduction of the level of
quasi-static speckles in the detected images by a factor 10 to 100 hence,
correspondingly improving the capacity to observe exoplanets.Comment: 11 pages, 14 figures, A&A accepted, 2nd version after language-editor
correction
Primary neurons that express the L2/HNK-1 carbohydrate during early development in the zebrafish
In zebrafish, many nerve pathways in both the CNS and periphery are pioneered by a small and relatively simple set of ‘primary’ neurons that arise in the early embryo. We now have used monoclonal antibodies to show that, as they develop, primary neurons of several functional classes express on their surfaces the L2/HNK-1 tetrasaccharide that is associated with a variety of cell surface adhesion molecules. We have studied the early labeling patterns of these neurons, as well as some non-neural cells, and found that the time of onset and intensity of immunolabeling vary specifically according to cell type. The first neuronal expression is by Rohon-Beard and trigeminal ganglion neurons, both of which are primary sensory neurons that mediate touch sensitivity. These cells express the epitope very strongly on their growth cones and axons, permitting study of their development unobscured by labeling in other cells. Both types initiate axogenesis at the same early time, and appear to be the first neurons in the embryo to do so. Their peripheral neurites display similar branching patterns and have similar distinctive growth cone morphologies. Their central axons grow at the same rate along the same longitudinal fiber pathway, but in opposite directions, and where they meet they appear to fasciculate with one another. The similarities suggest that Rohon-Beard and trigeminal ganglion neurons, despite their different positions, share a common program of early development. Immunolabeling is also specifically present on a region of the brain surface where the newly arriving trigeminal sensory axons will enter the brain. Further, the trigeminal expression of the antigen persists in growth cones during the time that they contact an individually identified central target neuron, the Mauthner cell, which also expresses the epitope. These findings provide descriptive evidence for possible roles of L2/HNK-1 immunoreactive molecules in axonal growth and synaptogenesis
A comparison of the responses of mature and young clonal tea to drought.
To assist commercial producers with optimising the use of irrigation water, the
responses to drought of mature and young tea crops (22 and 5 years after field
planting respectively) were compared using data from two adjacent long-term
irrigation experiments in Southern Tanzania. Providing the maximum potential
soil water deficit was below about 400-500 mm for mature, and 200-250 mm for
young plants (clone 6/8), annual yields of dry tea from rainfed or partially
irrigated crops were similar to those from the corresponding well-watered crops.
At deficits greater than this, annual yields declined rapidly in young tea (up
to 22 kg (ha mm)-1) but relatively slowly in mature tea (up to 6.5 kg (ha mm)-
1). This apparent insensitivity of the mature crop to drought was due
principally to compensation that occurred during the rains for yield lost in the
dry season. Differences in dry matter distribution and shoot to root ratios
contributed to these contrasting responses. Thus, the total above ground dry
mass of well-irrigated, mature plants was about twice that for young plants.
Similarly, the total mass of structural roots (>1 mm diameter), to 3 m depth,
was four times greater in the mature crop than in the young crop and, for fine
roots (<1 mm diameter), eight times greater. The corresponding shoot to root
ratios (dry mass) were about 1:1 and 2:1 respectively. In addition, each unit
area of leaf in the canopy of a mature plant had six times more fine roots (by
weight) available to extract and supply water than did a young plant. Despite
the logistical benefits resulting from more even crop distribution during the
year when crops are fully irrigated, producers currently prefer to save water
and energy costs by allowing a substantial soil water deficit to develop prior
to the start of the rains, up to 250 mm in mature tea, knowing that yield
compensation will occur later
A double peaked pulse profile observed in GX 1+4
The hard X-ray pulsar GX 1+4 was observed several times in the last few years
with a pair of balloon-borne Xenon filled Multi-cell Proportional Counters
(XMPC). In a balloon flight made on 22 March 1995, the source was detected in a
bright state, the average observed source count rate being per
detector. X-ray pulsations with a period of s were detected in
the source with a broad double peak pulse feature. When observed in December
1993 with the same instrument, the pulse profile of GX 1+4 showed a single
peak. This change in the pulse profile to a double pulse structure in about 15
months indicates either activation of the opposite pole of the neutron star if
the magnetic field is asymmetric or possibly a change in the beam pattern, from
a pencil beam to a fan beam. Assuming a fan beam configuration, the pulse
profile is used to find the inclinations of the magnetic axis and the viewing
axis with the spin axis. The derived angles support the GINGA observations of a
dip in the pulse profile which was resolved to have a local maximum in one of
the observations and was explained with resonance scattering of cyclotron line
energy photons by the accretion column (Makishima et al., \markcite{maki1988},
Dotani et al., \markcite{dotani1989}.). Compared to our previous observation of
the same source with the same telescope (Rao et al., \markcite{rao1994}) a
period change rate of is obtained which is the lowest rate
of change of period for this source since its discovery. Average pulse fraction
in the hard X-ray range is low (30%), consistent with its anti correlation with
luminosity as reported by us earlier (Rao et al., \markcite{rao1994}) and the
observed spectrum is very hard (power law photon index ).Comment: 10 pages, to appear in A&
A Complex Stereochemical Relay Approach To The Antimalarial Alkaloid Ocimicide A1. Evidence For A Structural Revision
Ocimicide A1 (1) and the semisynthetic derivative ocimicide A2 (2) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant Plasmodium falciparum strains with IC50 values in the nanomolar and picomolar range, respectively. Members of this family have demonstrated radical cure in rhesus monkeys, without detectable toxicity, but their structure–function relationships and mechanism of action are unknown. Herein we describe a twelve-step synthesis of an advanced N-acylated pentacyclic precursor to the proposed structure of 1 (11% overall yield). Instability and poor P. falciparum growth inhibition of the corresponding free donor–acceptor cyclopropylamine, and large discrepancies between reported and both experimental and DFT-calculated 13C chemical shifts and coupling constants, suggest that substantial revision of the proposed structures may be necessary
Recent experiences using finite-element-based structural optimization
Structural optimization has been available to the structural analysis community as a tool for many years. The popular use of displacement method finite-element techniques to analyze linearly elastic structures has resulted in an ability to calculate the weight and constraint gradients inexpensively for numerical optimization of structures. Here, recent experiences in the investigation and use of structural optimization are discussed. In particular, experience with the commercially available ADS/NASOPT code is addressed. An overview of the ADS/NASOPT procedure and how it was implemented is given. Two example problems are also discussed
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