A review of attitudes towards sharing geotechnical data and the use of geospatial data portals in Hong Kong and the U.K.: lessons for Europe

Reusing existing subsurface data can greatly cut the time and financial costs of site investigations, and reduce uncertainty regarding ground conditions that can result in delays and overspend. In Hong Kong SAR it is common practice for consultancies to deposit records in the form of factual and interpretive reports, borehole logs and laboratory test data with the Geotechnical Engineering Office (GEO) who make this information openly available to access for future investigative works. In addition to these deposits, other datasets available at GEO include, amongst others, landslide records, aerial photographs and as-built records. These archives are the first source of information about development sites in Hong Kong and no investigation takes place without a thorough desk study. Increasingly these data are digital, and can be accessed through a GIS-based online portal. In the U.K. the British Geological Survey (BGS) acts as a custodian for geoscience data deposited by the public and private sectors on a voluntary basis, and encourages organisations to make their data publicly available through the BGS online data portals. The facility to deposit digital data via the BGS website has recently been launched and should increase uptake of data sharing in the U.K. as it becomes easier for users to batch upload records digitally. Issues regarding data ownership and confidentiality are being overcome by the establishment, in some cities, of knowledge exchange networks where members who sign up to view data are expected under the terms of membership to deposit data. This has received backing from local government in some areas. The U.K. may not have the density of existing data that Hong Kong has but as knowledge exchange gathers momentum the BGS datasets are expected to grow rapidly. In Europe there appears to be a reluctance to share data. However, escalating demand for land, greater redevelopment of brownfield sites and an ever-growing need to ensure future construction and infrastructure projects are sustainable and compliant with European environmental targets means reusing data may have a role to play in increased subsurface knowledge, the reduction of unforeseen ground conditions and ultimately saving money. Data in .ags format is particularly favourable due to its uniform nature. First-hand experience of the approach towards disseminating geospatial data in Hong Kong and the U.K. will be presented, examining the difference in attitudes regarding data sharing in the two territories, and highlighting how it benefits ground investigations and geohazard assessment with the hope that Europe can learn lessons for the future and change old habits. The different systems of data sharing used in Hong Kong and the U.K. will be discussed, and their strengths and weaknesses evaluated with the aim of fostering a methodology for sharing geoscience data within Europe that benefits from the combined successes of both approaches and builds upon existing expertise

Monitoring groundwater temperatures in a shallow urban aquifer before, during and after installation of a Ground Source Heat System in Cardiff, U.K.

Exploitation of shallow urban aquifers, warmed by the Urban Heat Island Effect, is a relatively new concept in the U.K. An extensive groundwater temperature baseline monitoring network has been established for a shallow superficial aquifer in the city of Cardiff, U.K., to characterise groundwater temperatures and monitor the impacts of the first open-loop ground source heat pump (GSHP) installed in the city. In Spring 2014, temperature profiling was carried out at 1m depth intervals at 168 groundwater monitoring boreholes across Cardiff, establishing baseline groundwater temperatures within the shallow (<20m) superficial aquifer during the groundwater’s forecast coldest time of year. Data was contoured to form the first U.K. 2D city heat map. During the warmest time of year, Autumn 2014, a subset of boreholes were re-profiled to ascertain seasonal temperature variation, defining the Zone of Seasonal Fluctuation. Re-profiling was again carried out at these boreholes in Autumn 2015 to confirm these temperatures as normal for that time of year. By comparing Spring and Autumn profiles, the average depth to the base of the Zone of Seasonal Fluctuation was found to be 9.5mbgl. Two >100m boreholes showed the urban warming effect may extend to 80mbgl, before temperatures follow the predicted geothermal gradient. We term this the Zone of Anthropogenic Influence. After initial baseline temperatures were established, a site was selected for the installation of a shallow GSHP. Before installation work began, a monitoring network was set up to establish a temperature baseline for future GSHPs and identify any impacts on the thermal resource caused by removing ~2°C from the abstracted groundwater prior to reinjection into the aquifer. This comprised of 97 temperature loggers in 60 boreholes, including the abstraction and recharge boreholes and boreholes up and down gradient of the site. Some of these boreholes have multiple loggers at different depths, including the near-surface, but the majority of loggers were placed within the boreholes’ slotted sections, below the base of the Zone of Seasonal Fluctuation. In addition, six boreholes, including those used for the GSHP, have been telemetered, providing real-time temperature data. The aim of the monitoring network was to establish a baseline for groundwater temperatures in the shallow aquifer and to monitor local changes in temperatures close to the GSHP system. This study aimed to provide understanding of how GSHPs interact with the groundwater in order to confirm the sustainability of groundwater temperatures as a long-term thermal resource and provide planners with knowledge needed to develop sustainable wide-scale GSHP systems/networks. We present temperature data taken before and after installation

Hydro-geomechanical characterisation of a coastal urban aquifer using multiscalar time and frequency domain groundwater-level responses

Hydraulic properties of coastal, urban aquifers vary spatially and temporally with the complex dynamics of their hydrogeology and the heterogeneity of ocean-influenced hydraulic processes. Traditional aquifer characterisation methods are expensive, time-consuming and represent a snapshot in time. Tidal subsurface analysis (TSA) can passively characterise subsurface processes and establish hydro-geomechanical properties from groundwater head time-series but is typically applied to individual wells inland. Presented here, TSA is applied to a network of 116 groundwater boreholes to spatially characterise confinement and specific storage across a coastal aquifer at city-scale in Cardiff (UK) using a 23-year high-frequency time-series dataset. The dataset comprises Earth, atmospheric and oceanic signals, with the analysis conducted in the time domain, by calculating barometric response functions (BRFs), and in the frequency domain (TSA). By examining the damping and attenuation of groundwater response to ocean tides (OT) with distance from the coast/rivers, a multi-borehole comparison of TSA with BRF shows this combination of analyses facilitates disentangling the influence of tidal signals and estimation of spatially distributed aquifer properties for non-OT-influenced boreholes. The time-series analysed covers a period pre- and post-impoundment of Cardiff’s rivers by a barrage, revealing the consequent reduction in subsurface OT signal propagation post-construction. The results indicate that a much higher degree of confined conditions exist across the aquifer than previously thought (specific storage = 2.3 × 10−6 to 7.9 × 10−5 m−1), with implications for understanding aquifer recharge, and informing the best strategies for utilising groundwater and shallow geothermal resources

Primacy of effective communication and its influence on adherence to artemether-lumefantrine treatment for children under five years of age: a qualitative study.

BACKGROUND\ud \ud Prompt access to artemesinin-combination therapy (ACT) is not adequate unless the drug is taken according to treatment guidelines. Adherence to the treatment schedule is important to preserve efficacy of the drug. Although some community based studies have reported fairly high levels of adherence, data on factors influencing adherence to artemether-lumefantrine (AL) treatment schedule remain inadequate. This study was carried-out to explore the provider's instructions to caretakers, caretakers' understanding of the instructions and how that understanding was likely to influence their practice with regard to adhering to AL treatment schedule.\ud \ud METHODS\ud \ud A qualitative study was conducted in five villages in Kilosa district, Tanzania. In-depth interviews were held with providers that included prescribers and dispensers; and caretakers whose children had just received AL treatment. Information was collected on providers' instructions to caretakers regarding dose timing and how to administer AL; and caretakers' understanding of providers' instructions.\ud \ud RESULTS\ud \ud Mismatch was found on providers' instructions as regards to dose timing. Some providers' (dogmatists) instructions were based on strict hourly schedule (conventional) which was likely to lead to administering some doses in awkward hours and completing treatment several hours before the scheduled time. Other providers (pragmatists) based their instruction on the existing circumstances (contextual) which was likely to lead to delays in administering the initial dose with serious treatment outcomes. Findings suggest that, the national treatment guidelines do not provide explicit information on how to address the various scenarios found in the field. A communication gap was also noted in which some important instructions on how to administer the doses were sometimes not provided or were given with false reasons.\ud \ud CONCLUSIONS\ud \ud There is need for a review of the national malaria treatment guidelines to address local context. In the review, emphasis should be put on on-the-job training to address practical problems faced by providers in the course of their work. Further research is needed to determine the implication of completing AL treatment prior to scheduled time

Groundwater heat pump feasibility in shallow urban aquifers: experience from Cardiff, UK

Ground source heat pumps have the potential to decarbonise heating and cooling in many urban areas. The impact of using shallow groundwater from unconsolidated sedimentary aquifers for heating in urban areas is often modelled, but rarely validated from field measurements. This study presents findings from the ‘Cardiff Urban Geo-Observatory’ project. This study focuses on an experimental open loop ground source heat pump scheme retrofitted to a school building. Field monitoring for three years between 2015 and 2018 provided data on the environmental impact of the scheme on aquifer conditions. Average aquifer thermal degradation in the first three years was kept below 2 °C, with a maximum change of 4 °C measured during the heating season. The numerically modelled predictions of thermal degradation around the production and injection wells are compared with long-term field monitoring data, providing new insights into both aquifer, and user, behaviour. The Seasonal Performance Factor (SPFH4) of the pilot installation was 4.5 (W13/W50) in the monitoring period. An initial thermal resource estimation of the wider aquifer volume suggests that lowering the temperature of the aquifer by 8 °C could generate equivalent to 26% of the city's 2020 heating demand, but achievable heat extraction would in reality, be less. The study concludes that large parts of the aquifer can sustain shallow open loop ground source heat pump systems, as long as the local ground conditions support the required groundwater abstraction and re-injection rates. Future schemes can be de-risked and better managed by introduction of a registration of all GSHP schemes, with open sharing of investigation, design and performance monitoring data, and by managing thermal interference between systems using spatial planning tools

Multi-Messenger Astronomy with Extremely Large Telescopes

The field of time-domain astrophysics has entered the era of Multi-messenger Astronomy (MMA). One key science goal for the next decade (and beyond) will be to characterize gravitational wave (GW) and neutrino sources using the next generation of Extremely Large Telescopes (ELTs). These studies will have a broad impact across astrophysics, informing our knowledge of the production and enrichment history of the heaviest chemical elements, constrain the dense matter equation of state, provide independent constraints on cosmology, increase our understanding of particle acceleration in shocks and jets, and study the lives of black holes in the universe. Future GW detectors will greatly improve their sensitivity during the coming decade, as will near-infrared telescopes capable of independently finding kilonovae from neutron star mergers. However, the electromagnetic counterparts to high-frequency (LIGO/Virgo band) GW sources will be distant and faint and thus demand ELT capabilities for characterization. ELTs will be important and necessary contributors to an advanced and complete multi-messenger network.Comment: White paper submitted to the Astro2020 Decadal Surve

Results from the GeoERA MUSE shallow geothermal project – UK Cardiff pilot area

Shallow geothermal energy systems deployment will play an important part in decarbonisation of heating and cooling of buildings. This trend will stimulate research into ground physical, thermal and hydraulic properties and impacts on urban aquifers and infrastructures. Moreover, subsurface heat extraction must be perceived as reliable, sustainable and equitable to create an environment for social acceptance and uptake of geothermal technologies. The EU H2020-funded GeoERA ‘MUSE’ project (2018-2021), involved 16 Geological Surveys, who shared methods and developed harmonised workflows for the evaluation of shallow geothermal resources in European urban areas (Götzl et al., EGC 2022). The project deployed and tested ground characterisation and geophysical monitoring techniques, monitored GSHP schemes, analysed the local market situation, produced fact sheets, made policy recommendations, and developed adaptive management strategies. The research included in-field monitoring studies in 14 urban pilot areas across Europe, including three UK urban pilot areas; Cardiff in south Wales, Glasgow in west Scotland and Colchester in east England. This paper summarises the result with a focus on the Cardiff area

Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial.

Severe alcoholic hepatitis (sAH) is associated with a poor prognosis. There is no proven effective treatment for sAH, which is why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors and were tested in an extracorporeal cellular therapy (ELAD) study to establish their effect on survival for subjects with sAH. Adults with sAH, bilirubin ≥8 mg/dL, Maddrey\u27s discriminant function ≥ 32, and Model for End-Stage Liver Disease (MELD) score ≤ 35 were randomized to receive standard of care (SOC) only or 3-5 days of continuous ELAD treatment plus SOC. After a minimum follow-up of 91 days, overall survival (OS) was assessed by using a Kaplan-Meier survival analysis. A total of 203 subjects were enrolled (96 ELAD and 107 SOC) at 40 sites worldwide. Comparison of baseline characteristics showed no significant differences between groups and within subgroups. There was no significant difference in serious adverse events between the 2 groups. In an analysis of the intent-to-treat population, there was no difference in OS (51.0% versus 49.5%). The study failed its primary and secondary end point in a population with sAH and with a MELD ranging from 18 to 35 and no upper age limit. In the prespecified analysis of subjects with MELD \u3c 28 (n = 120), ELAD was associated with a trend toward higher OS at 91 days (68.6% versus 53.6%; P = .08). Regression analysis identified high creatinine and international normalized ratio, but not bilirubin, as the MELD components predicting negative outcomes with ELAD. A new trial investigating a potential benefit of ELAD in younger subjects with sufficient renal function and less severe coagulopathy has been initiated. Liver Transplantation 24 380-393 2018 AASLD

Earthquakes drive large-scale submarine canyondevelopment and sediment supply to deep-ocean basins

Although the global flux of sediment and carbon from land to the coastal ocean is well known, the volume of material that reaches the deep ocean—the ultimate sink—and the mechanisms by which it is transferred are poorly documented. Using a globally unique data set of repeat seafloor measurements and samples, we show that the moment magnitude (Mw) 7.8 November 2016 Kaikōura earthquake (New Zealand) triggered widespread landslides in a submarine canyon, causing a powerful “canyon flushing” event and turbidity current that traveled >680 km along one of the world’s longest deep-sea channels. These observations provide the first quantification of seafloor landscape change and large-scale sediment transport associated with an earthquake-triggered full canyon flushing event. The calculated interevent time of ~140 years indicates a canyon incision rate of 40 mm year−1, substantially higher than that of most terrestrial rivers, while synchronously transferring large volumes of sediment [850 metric megatons (Mt)] and organic carbon (7 Mt) to the deep ocean. These observations demonstrate that earthquake-triggered canyon flushing is a primary driver of submarine canyon development and material transfer from active continental margins to the deep ocean.peer-reviewe

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

SPL7013 Gel (VivaGel®) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed retention and duration of antiviral activity following vaginal administration of 3% SPL7013 Gel in healthy women. Participants received 5 single doses of product with ≥5 days between doses. A cervicovaginal fluid (CVF) sample was collected using a SoftCup™ pre-dose, and immediately, or 1, 3, 12 or 24 h post-dose. HIV-1 and HSV-2 antiviral activities of CVF samples were determined in cell culture assays. Antiviral activity in the presence of seminal plasma was also tested. Mass and concentration of SPL7013 in CVF samples was determined. Safety was assessed by reporting of adverse events. Statistical analysis was performed using the Wilcoxon signed-rank test with Bonferroni adjustment; p≤0.003 was significant. Eleven participants completed the study. Inhibition of HIV-1 and HSV-2 by pre-dose CVF samples was negligible. CVF samples obtained immediately after dosing almost completely inhibited (median, interquartile range) HIV-1 [96% (95,97)] and HSV-2 [86% (85,94)], and activity was maintained in all women at 3 h (HIV-1 [96% (95,98), p = 0.9]; HSV-2 [94% (91,97), p = 0.005]). At 24 h, >90% of initial HIV-1 and HSV-2 inhibition was maintained in 6/11 women. SPL7013 was recovered in CVF samples obtained at baseline (46% of 105 mg dose). At 3 and 24 h, 22 mg and 4 mg SPL7013, respectively, were recovered. More than 70% inhibition of HIV-1 and HSV-2 was observed if there was >0.5 mg SPL7013 in CVF samples. High levels of antiviral activity were retained in the presence of seminal plasma. VivaGel was well tolerated with no signs or symptoms of vaginal, vulvar or cervical irritation reported. Potent antiviral activity was observed against HIV-1 and HSV-2 immediately following vaginal administration of VivaGel, with activity maintained for at least 3 h post-dose. The data provide evidence of antiviral activity in a clinical setting, and suggest VivaGel could be administered up to 3 h before coitus