Boarding School Syndrome: A Phenomenological Study Giving Single-Gender Military Boarding School Alumni a Voice to Tell Their Stories of Life After Graduation

The purpose of this phenomenological study was to understand boarding school syndrome for single-gender boarding school alumni. The theory guiding this study was Erikson’s (1968) socioemotional development theory as it describes human development. Development during Erikson’s adolescent period is fragile. This fragile adolescent period is interrupted when students are separated from their families and placed in the boarding school environment under the care of strangers. Research indicates boarding school syndrome correlates with relationship difficulties, college struggles and employment problems of military boarding school graduates (Marsh, 2011; Schaverien, 2011). Schaverien (2011) created the term boarding school syndrome after treating a significant number of boarding school students in her psychiatry practice. The participants of the present study were purposefully selected to include 10 graduates from single-gender military boarding schools. Participants were selected through an initial purposeful sample, followed by convenience, and then snowball sampling. Participant narratives were gathered through individual interviews, a single online focus group and journaling interviews to reveal the essence of the phenomenon and journaling. Data analysis was accomplished through coding procedures to extract and prioritize statements. These statements were then be broken down, coded into units of textual meaning, then reorganized according to central themes which will form the results of the study

One-shot Manufacturing Techniques Developed for Carbon Fiber Prepreg Components

The need for faster and more accurate manufacturing methods for composite parts continues to grow. Co-curing composite structures can decrease manufacturing time by eliminating secondary operations such as grinding, jigging, bonding, and fastening while creating lighter and more accurate parts. As a demonstrator for co-curing techniques, a six-meter carbon fiber wing for a high-altitude and high-speed dynamically soaring unmanned aerial vehicle (UAV) was designed and manufactured in one cure cycle. Two wing-skin molds were created using low density tooling board, with the mold geometry directly machined into the material, reducing tool manufacturing time and cost. An aluminum insert was used to create a trailing edge cavity while maintaining a simple parting line of the wing tool. Three removable forms made of polystyrene foam inside of the wing cavity were used to position six internal webs and, after curing and removal of the forms, resulted in a hollow wing with internal webs. The resulting wings showed some defects in the wing skins but overall produced structurally sound parts.Expanding on the previous co-curing techniques, a 1.1-meter carbon fiber horizontal stabilizer with internal structure and an elevator connected by a composite flexure was designed and manufactured in one cure cycle. The stabilizer is used in a high-altitude and high-speed dynamically soaring unmanned aerial vehicle (UAV). The top skin is used as the flexure, creating a seamless top surface between the stabilizer and elevator. Three removable forms made of polystyrene foam were used inside the stabilizer to position a spar web and center rib, which after curing and removal of the forms resulted in a hollow stabilizer with an internal web and rib. The resulting stabilizers showed minor defects in the wing skins but overall produced structurally sound parts.The demonstrators showed the great potential for creating complex composite parts and assemblies using only a single cure cycle while needing little finishing work and no secondary bonding, resulting in high precision at relatively low cost.Utilizing the components produced, the JetStreamer was able to be assembled and flown in Weldon, The JetStreamer is believed to be the largest unmanned aircraft to demonstrate dynamic soaring

Manufacturing Techniques Developed for the JetStreamer Dynamic Soaring UAV

While many theories on dynamic soaring are emerging, most testing of these theories has been done using small R/C aircraft and some basic manned flights. This work focuses on developing and manufacturing the JetStreamer, a 6.5 meter wingspan UAV, to act as a test platform for dynamics soaring techniques. The aircraft\u27s main purpose is to test if dynamic soaring can be done in the jet stream along with real-time wind field estimation.First, a basic design and analysis was performed for the JetStreamer, from there, small test sections of aircraft components were created to investigate one-shot manufacturing techniques to be used on the full-scale parts. Processes for creating integrated wing spars as well as internal shear webs in a one shot process were developed.Construction of the JetStreamer then began and during its construction, the one-shot processes were verified on a 6 meter carbon fiber wing. Most notably, the main wing was successfully manufactured using a one-shot process that produced a complete wing with integrated wing spars, an internal shear web structure, and provisions for attachment of control surfaces

A New Species of \u3ci\u3ePterygodermatites\u3c/i\u3e (Nematoda: Rictulariidae) from the Incan Shrew Opossum, \u3ci\u3eLestoros inca\u3c/i\u3e

Pterygodermatites (Paucipectines) hymanae n. sp. (Rictulariidae) collected from the Incan shrew opossum, Lestoros inca, from Peru is described herein. These nematodes show a subapical, slightly dorsal oral opening and a laterally compressed buccal capsule with 2 conspicuous lateral walls and a dorsal wall. Each lateroventral wall possesses 4 relatively large denticles, and the dorsal wall has 6 denticles. Females are characterized by a conspicuously large postvulvar 37th spine, which may reach 1 mm. This is the first record of endoparasites in the Incan shrew opossum and the fifth species of Pterygodermatites recorded in New World marsupials

Maternal glucose and fatty acid kinetics and infant birth weight in obese women with type 2 diabetes

The objectives of this study were 1) to describe maternal glucose and lipid kinetics and 2) to examine the relationships with infant birth weight in obese women with pregestational type 2 diabetes during late pregnancy. Using stable isotope tracer methodology and mass spectrometry, maternal glucose and lipid kinetic rates during the basal condition were compared in three groups: lean women without diabetes (Lean, n = 25), obese women without diabetes (OB, n = 26), and obese women with pregestational type 2 diabetes (OB+DM, n = 28; total n = 79). Glucose and lipid kinetics during hyperinsulinemia were also measured in a subset of participants (n = 56). Relationships between maternal glucose and lipid kinetics during both conditions and infant birth weight were examined. Maternal endogenous glucose production (EGP) rate was higher in OB+DM than OB and Lean during hyperinsulinemia. Maternal insulin value at 50% palmitate R(a) suppression (IC50) for palmitate suppression with insulinemia was higher in OB+DM than OB and Lean. Maternal EGP per unit insulin and plasma free fatty acid concentration during hyperinsulinemia most strongly predicted infant birth weight. Our findings suggest maternal fatty acid and glucose kinetics are altered during late pregnancy and might suggest a mechanism for higher birth weight in obese women with pregestational diabetes

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

OBJECTIVE: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, we investigated the impact of CCR5 blockade via the CCR5-specific antibody leronlimab on clinical, immunological, and virological parameters in severe COVID-19 patients. METHODS: In March 2020, 10 terminally ill, critical COVID-19 patients received two doses of leronlimab via individual emergency use indication. We analyzed changes in clinical presentation, immune cell populations, inflammation, as well as SARS-CoV-2 plasma viremia before and 14 days after treatment. RESULTS: Over the 14-day study period, six patients survived, two were extubated, and one discharged. We observed complete CCR5 receptor occupancy in all donors by day 7. Compared with the baseline, we observed a concomitant statistically significant reduction in plasma IL-6, restoration of the CD4/CD8 ratio, and resolution of SARS-CoV2 plasma viremia (pVL). Furthermore, the increase in the CD8 percentage was inversely correlated with the reduction in pVL (r = -0.77, p = 0.0013). CONCLUSIONS: Our study design precludes clinical efficacy inferences but the results implicate CCR5 as a therapeutic target for COVID-19 and they form the basis for ongoing randomized clinical trials

Reviews

The War of the Ring. J.R.R Tolkien. Reviewed by Glen GoodKnight. Bilbo\u27s Last Song. J.R.R Tolkien, Illust. by Pauline Baynes. Reviewed by Nancy-Lou Patterson. Owen Barfield and C.S. Lewis. Owen Barfield. Reviewed by Nancy-Lou Patterson. A Christian for All Christians: Essays in Honour of C.S. Lewis. Andrew Walker and James Patrick, Ed.. Reviewed by Nancy-Lou Patterson. The Hobbit. J.R.R. Tolkien, Illus. by David Wenzel, Adapted by Charles Dixon and Sean Deming. Reviewed by Glen GoodKnight. The Mind of the Maker. Dorothy L. Sayers. Reviewed by Nancy-Lou Patterson. The Pattern in the Web: The Mythical Poetry of Charles Williams. Roma A. King, Jr.. Reviewed by Nancy-Lou Patterson. The Land of Narnia. Biran Sibley, Illus. by Pauline Baynes. Reviewed by Glen GoodKnight. Dangerous By Degrees: Women at Oxford and the Somerville Novelists. Susan J. Leonardi. Reviewed by Nancy-Lou Patterson. The 1991 J.R.R. Tolkien Calendar. Illust. by John Howe. Reviewed by Bruce Leonard

Introduction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75737/1/j.1095-8312.1986.tb01745.x.pd

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.

OBJECTIVE:Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS:Forty people with obesity (BMI = 37.9 ± 4.3 kg/m2 ) were randomized to weight maintenance (n = 14) or weight loss (n = 19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11%, and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-2 H2 ]glucose tracer infusion was used to assess glucose kinetics. RESULTS:At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r = 0.532; P = 0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r = -0.361; P = 0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r = 0.654; P = 0.002) and the increase in insulin sensitivity (r = -0.595; P = 0.007). CONCLUSIONS:This study demonstrates the interrelationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and it suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance