31 research outputs found
Current cosmological bounds on neutrino masses and relativistic relics
We combine the most recent observations of large-scale structure (2dF and
SDSS galaxy surveys) and cosmic microwave anisotropies (WMAP and ACBAR) to put
constraints on flat cosmological models where the number of massive neutrinos
and of massless relativistic relics are both left arbitrary. We discuss the
impact of each dataset and of various priors on our bounds. For the standard
case of three thermalized neutrinos, we find an upper bound on the total
neutrino mass sum m_nu < 1.0 (resp. 0.6) eV (at 2sigma), using only CMB and LSS
data (resp. including priors from supernovae data and the HST Key Project), a
bound that is quite insensitive to the splitting of the total mass between the
three species. When the total number of neutrinos or relativistic relics N_eff
is left free, the upper bound on sum m_nu (at 2sigma, including all priors)
ranges from 1.0 to 1.5 eV depending on the mass splitting. We provide an
explanation of the parameter degeneracy that allows larger values of the masses
when N_eff increases. Finally, we show that the limit on the total neutrino
mass is not significantly modified in the presence of primordial gravitational
waves, because current data provide a clear distinction between the
corresponding effects.Comment: 13 pages, 6 figure
Ecological effects of experimental drought and prescribed fire in a southern California coastal grassland
How drought and fire disturbance influence different levels of biological organization is poorly understood but essential for robust predictions of the effects of environmental change. During a year of severe drought, we conducted a prescribed fire in a Mediterranean-type coastal grassland near Irvine, California. In the weeks following the fire we experimentally manipulated rainfall in burned and unburned portions of the grassland to determine how fire and drought interact to influence leaf physiological performance, community composition, aboveground net primary productivity (ANPP) and component fluxes of ecosystem CO2 exchange and evapotranspiration (ET). Fire increased leaf photosynthesis (A
net) and transpiration (T) of the native perennial bunchgrass, Nassella pulchra and the non-native annual grass, Bromus diandrus but did not influence ANPP or net ecosystem CO2 exchange (NEE). Surprisingly, drought only weakly influenced A
net and T of both species but strongly influenced ANPP and NEE. We conclude that despite increasing experimental drought severity, prescribed fire influenced leaf CO2 and H2O exchange but had little effect on the component fluxes of ecosystem CO2 exchange. The differential effects of prescribed fire on leaf and ecosystem processes with increasingly severe drought highlight the challenge of predicting the responses of biological systems to disturbance and resource limitation
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation. Analysis of blood cell traits in the UK Biobank and other cohorts illuminates the full genetic architecture of hematopoietic phenotypes, with evidence supporting the omnigenic model for complex traits and linking polygenic burden with monogenic blood diseases
Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67–82]), than encephalopathy (54% [42–65]). Intensive care use was high (38% [35–41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27–32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission
The conundrum of parapsoriasis versus patch stage of mycosis fungoides
Terminological confusion with benign dermatosis, such as parapsoriasis
en plaques, makes it difficult to diagnose mycosis fungoides in the
early patch stage. Early diagnosis of mycosis fungoides (MF) is
important for deciding on type of therapy, prognosis and for further
follow-up. However, until recently, there has been no consensus on
criteria that would help in diagnosing the disease early. Some believe
that large plaque parapsoriasis (LPP) should be classified with early
patch stage of MF and should be treated aggressively. However, there is
no firm clinical or laboratory criteria to predict which LPP will
progress to MF and we can only discuss about statistical probability.
Moreover, long-term outcome analysis of even patch stage of MF is
similar to that of control population. We therefore believe that LPP
should be considered as a separate entity at least to prevent the
patient from being given a frightening diagnosis. We also feel that
patients need not be treated with aggressive therapy for LPP and will
need only a close follow-up. This article emphasizes the criteria for
diagnosing early MF and has highlighted the importance of considering
LPP as a distinct benign entity