Co-construcción del Plan Estratégico de Cultura Ciudadana en las Escuelas de Formación Deportiva, con jóvenes de 14 a 17 años inscritos al Instituto Municipal de Cultura Recreación y Deporte de Zipaquirá (IMCRDZ), a través de una estrategia participativa y la conformación de redes y alianzas.

Contribuir al fortalecimiento de la cultura ciudadana a partir de una metodología que integra la participación y la generación de redes y alianzas, para la co-construcción del Plan Estratégico con los jóvenes de 14 a 17 años del Instituto Municipal de Cultura, Recreación y Deporte de Zipaquirá (IMCRDZ)El presente proyecto muestra la importancia del ejercicio participativo desde la perspectiva y el reconocimiento de la cultura ciudadana. En el mismo, dando una aproximación teórica, a partir de las posturas de diversos autores frente a la importancia de este acuerdo social para regular y gestionar el comportamiento humano en sociedad, tanto a nivel individual como colectivo. Se espera que la co-creación del Plan Estratégico a partir de la Investigación Acción Participativa, con la vinculación de jóvenes entre los 14 y 17 años de entidades como el Instituto Municipal de Recreación y Deportes de Zipaquirá (IMRDZ), para fortalecer la cultura ciudadana y generar en los jóvenes identidad de los principios, compromisos éticos y entramado institucional del Municipio.This project shows the importance of participatory exercise from the perspective and recognition of civic culture. In it, a theoretical approach will be presented, based on the positions of various authors regarding the importance of this social agreement to regulate and manage human behavior in society, both individually and collectively. The co-creation of the Strategic Plan is expected from the Participatory Action Research that links young people between 14 and 17 years old to (from) entities such as the Municipal Institute of Recreation and Sports of Zipaquirá (IMRDZ) to strengthen culture citizenship and generate in young people and identity of the principles, ethical commitments and institutional framework of the Municipality.Corporación Universitaria Minuto de Dio

Co-construcción del Plan Estratégico de Cultura Ciudadana en las Escuelas de Formación Deportiva, con jóvenes de 14 a 17 años inscritos al Instituto Municipal de Cultura Recreación y Deporte de Zipaquirá (IMCRDZ), a través de una estrategia participativa y la conformación de redes y alianzas.

Contribuir al fortalecimiento de la cultura ciudadana a partir de una metodología que integra la participación y la generación de redes y alianzas, para la co-construcción del Plan Estratégico con los jóvenes de 14 a 17 años del Instituto Municipal de Cultura, Recreación y Deporte de Zipaquirá (IMCRDZ)El presente proyecto muestra la importancia del ejercicio participativo desde la perspectiva y el reconocimiento de la cultura ciudadana. En el mismo, dando una aproximación teórica, a partir de las posturas de diversos autores frente a la importancia de este acuerdo social para regular y gestionar el comportamiento humano en sociedad, tanto a nivel individual como colectivo. Se espera que la co-creación del Plan Estratégico a partir de la Investigación Acción Participativa, con la vinculación de jóvenes entre los 14 y 17 años de entidades como el Instituto Municipal de Recreación y Deportes de Zipaquirá (IMRDZ), para fortalecer la cultura ciudadana y generar en los jóvenes identidad de los principios, compromisos éticos y entramado institucional del Municipio.This project shows the importance of participatory exercise from the perspective and recognition of civic culture. In it, a theoretical approach will be presented, based on the positions of various authors regarding the importance of this social agreement to regulate and manage human behavior in society, both individually and collectively. The co-creation of the Strategic Plan is expected from the Participatory Action Research that links young people between 14 and 17 years old to (from) entities such as the Municipal Institute of Recreation and Sports of Zipaquirá (IMRDZ) to strengthen culture citizenship and generate in young people and identity of the principles, ethical commitments and institutional framework of the Municipality.Corporación Universitaria Minuto de Dio

Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations.

The B cell receptor immunoglobulin (BcR IG) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n=488) i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL) as well as provisional entities (n=76) according to the World Health Organization classification. The most striking IG gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different IG gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ IG sequence dataset with a large dataset of IG sequences (MZ-related or not; n=65,837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia but also rheumatoid factors and non-malignant spleen MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms, may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments.This work was supported in part by H2020 “AEGLE, An analytics framework for integrated and personalized healthcare services in Europe”, by the European Union (EU); H2020 No. 692298 project “MEDGENET, Medical Genomics and Epigenomics Network” by the EU; grant AZV 15-30015A from the Ministry of Health of the Czech Republic, and the project CEITEC2020 LQ1601 from the Ministry of Education, Youth, and Sports of the Czech Republic; Bloodwise Research Grant (15019); the Swedish Cancer Society, the Swedish Research Council, the Knut and Alice Wallenberg Foundation, Karolinska Institutet, Stockholm, the Lion’s Cancer Research Foundation, Uppsala, the Marcus Borgström Foundation and Selander’s Foundation, Uppsala

The Importance of Designing for Pollinators

More than 40% of insect species are declining and a third are endangered. Monarch Butterflies population has plummeted 99.9% since the 1980s. This poses a tremendous risk to our ecosystem. This talk will reflect on how Patricia\u27s love for bees has led her on a path that transformed how she approaches design as activism while harnessing the creative process. She believes that landscape architects have an important role and the potential to make a big impact for insect survival. Patricia was born and raised in Mexico, she is the founding principal of BASE. A recognized leader in sustainable design and community involvement, Patricia creates landscapes that immerse people of all backgrounds and abilities in learning, exploration and play. Patricia’s community involvement and advocacy expand the boundaries of traditional landscape architecture. She founded an NGO that creates healthy habitats for pollinators. She has lectured at many universities and has won two national faculty ASLA awards. She received her MLA from UC Berkeley in 2007.https://digitalcommons.usu.edu/laep_speakerseries/1005/thumbnail.jp

Relación entre composición corporal y concentración de leptina sérica en mujeres estudiantes de nivel superior

El objetivo del presente trabajo fué conocer la relación y la fuerza de asociación que existe entre composición corporal y la concentración sérica de leptina en una población de mujeres. Se evaluaron 60 mujeres de entre 18 y 21 años de la Benemérita y Centenaria Escuela Normal del Estado de San Luis Potosí (BECENE). Se realizaron mediciones de: perímetro de cintura y cadera, talla, peso, porcentaje de masa grasa y niveles plasmáticos de: glucosa, colesterol total, triglicéridos, HDL, LDL, leptina e insulina. El procesamiento de datos se realizó en IBM SPSS Statistics 20.0 (IBM Corp.), se utilizó estadística descriptiva, regresión lineal y regresión logística binomial, así como diferencia de medianas con una confiabilidad al 95%. La población estudiada presentó valores normales de glucemia y presión arterial media, sin embargo también se observó un 3% con hipercolesterolemia total; un 29,9% con sobrepeso/ obesidad; y un 26% con resistencia a insulina (HOMA2 IR mayor a 1.4). La mediana de leptina sérica fue de 6,49 ng/ml, donde un 30% de las mujeres se encontraban en condiciones de hiperleptinemia. Se observó una correlación significativa entre los niveles séricos de leptina y porcentaje de masa grasa, IMC, insulina sérica e índice HOMA2-IR. Por regresión logística binomial se observó que el IMC elevado aumenta la probabilidad de padecer hiperleptinemia 7,5 veces, y los niveles altos de masa grasa aumentan el riesgo 6,2 veces. El mejor predictor de hiperleptinemia fue el IMC.Sixty women aged between 18 and 21 from the Benemérita y Centenaria Escuela Normal del Estado de San Luis Potosí (BECENE) were evaluated. Body mass index, fat mass percentage, waist-hip ratio and several plasma components were analyzed: glucose, total colesterol, free tryglycerides, HDL, LDL, insulin and leptin. Data was processed by SPSS Statistics 20,0 software using descriptive statistics, binomial logistic regression with a confidence value of 95%. The population showed normal glycemic and blood pressure values, whereas a 29,9% of women were overweight/obese, 3% showed hypercholesterolemia and 29,9% showed insulin resistance (HOMA2 IR over 1.4). The median for blood leptin was 6.49 ng/ml, and 30% of women were hyperleptinemic. A positive and significant correlation was observed between blood leptin values and BMI, % fat mass, blood insulin and HOMA2-IR index. The odds ratio analyzed for BMI, showed that overweight and obesity increase 7,5 times the risk of hyperleptinemia. On the other hand, high levels of fat mass, increase by 6,2 times the risk of hyperleptinemia. So far, the best predictor for hyperleptinema is BMI

Bismethylgliotoxin is detected in serum from oncohaematological neutropaenic paediatric patients: presentation of two cases of probable IPA with negative galactomanan and positive bmGT

Abstract of the poster presented at the 30th ECCMID 2020, European Congress of Clinical Microbiology and Infectious Diseases, organized by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).-- www.eccmid.org .-- www.escmid.org.-- Abstract 6251.[Background] Invasive pulmonary aspergillosis (IPA) is a leading cause of morbidity and mortality in immunocompromised oncohematology pediatric patients. This is mainly due to the absence of optimal diagnostic modalities, which hamper early specific disease detection and treatment. Thus, diagnosis of IA is still challenging and constitutes a major problem during management of pediatric patients at risk of infection, where the number of studies validating different diagnosis biomarkers is more limited. In a previous study, we demonstrated the high diagnostic accuracy of bis(methyl)gliotoxin(bmGT) compared to GM for IPA diagnosis in adults. The objective of this study is to show bmGT suitability for IPA diagnosis in oncopediatric patients in comparison with GM, monitoring the course of bmGT concentration in serum during voriconazole treatment.[Materials/methods] The presence and concentration of bmGT and voriconazole in sequential serum series from 9 oncopediatric patients with febrile neutropenia (retrospective and prospective samples) were simultaneously quantified by High Performance Thin Layer Chromatography (HPTLC) and confirmed using LC/MS/MS by an independent lab.[Results] HPTLC allowed simultaneous sensitive detection of bmGT and voriconazole in serum and BAL of pediatric patients confirmed by LC/MS/MS. We present two patients (17 and 36 months). In the phase of prolonged neutropenia, fever, hypoxemia and pulmonary infiltration compatible with Aspergillosis in high resolution CT are started. In one patient, bmGT was detected earlier than GM, allowing early initiation of treatment, with the voriconazole treatment the GM was negativized and the bmGT levels decreased. In the second patient, GM was negative and bmGT positive in serum and BAL, so treatment with voriconazole was started, then a decrease in bmGT values was detected coinciding with the patient clinical improvement.[Conclusions] The determination of bmGT in pediatric patients allowed the early diagnosis and effective treatment of two cases of IA, being a promising tool in neutropenic pediatric patients at risk of IPA. Identification of bmGT by HPTLC has been confirmed by LC/MS/MS indicating the presence of this biomarker during IPA in pediatric population. Analyses to establish the performance of serum bmGT detection together with beta-d-Glucan, PCR and IL8 to diagnose IPA in pediatric oncohematological patients are ongoing.Peer reviewe