A comparative clinical study to access the role of Basti and Virechana Karma followed by Rasayana in post menopausal Asthikshaya (Osteoporosis)

Rajonivrutti condition manifests in the end phase of Jarawastha; but its Samprapti begins from the Sandhikala of Madhyamawastha and Jarawastha due to Vatavruddi in womens reaching Rajonivrutti. Postmenopausal Asthikshaya is a disabling disease, which renders women a bedridden life. Here 40 subjects diagnosed with postmenopausal Asthikshaya fulfilling the inclusion criteria were selected for the study and randomly categorized intp two groups as group A and group B each consisting of 20 subjects. Group A received Amapachana with Hinguvachadivati, Yastimadhu Siddha Ksheerabasti administered in Yoga Basti schedule followed by Tritiyatriphala Rasayana. Group B received Amapachana with Hinguvachadivati, Sadhyosnehapana with Amrita Ghrita, Sarvanga Abyanga with Murchita Tilataila followed by Sarvanga Swedana and Sneha Virechana was admistered with Eranda Taila followed by Tritiyatriphala Rasayana was given. Tritiya Triphala Rasayana selected for the present study by adapting all the general principles of prevention and management of Asthikshaya and as it is a well known Rasayana

Prachanna Karma - An effective procedure in the management of Indralupta followed by Icchabhediya Rasa as Lepa and Shamanoushadi - A Case Report

Hair is the first most noticeable part of body. It enhances personality. As the cliché goes “your hair is your crown and glory” no matter the gender. The hair, after all is your best accessory. It forms an important anatomical structure of the body which not only have protective function. Increased industrialization and urbanization has constituted greater exposure to pollution contamination of water, air, food habits, and life style modification due to their intrinsic factors. Hence there is definite increase in the incidence of hair fall. Hair disorders cause negative impact towards the individual quality of life. Indralupta is a Kshudraroga characterized by loss of hair. It can be correlated with alopecia areata, which is having chief complaint of hair loss on scalp without any clinical inflammatory signs. In modern science treatment modalities like use of corticosteroid, laser therapy but all have lots of adverse effect. In Ayurveda literature Acharyas had briefly explain hair and mentioned many more modalities to treat hair loss. Nidana Parivarjana, Prachanna, Shamanoushadhi and externally use of Lepa

Prospective Randomized Control Trial Comparing the Efficacy of Diathermy Incision versus Scalpel Incision over Skin in Patients Undergoing Inguinal Hernia Repair

AbstractBackground: Electrocautery in surgery is widely used except for the skin incisions, this is because of fear of scarring of tissues, post operative pain, and wound infection in view of devitalisation of tissues. This study compares the scalpel incisions with electrocautery incision over skin in patients undergoing hernia repair.Materials and Methods:In this study prospective randomized study 60 patients undergoing mesh repair for inguinal hernia are divided in to two groups. In Group A   skin incision is taken with electrocautery , and in  Group B  incision is taken with scalpel. Postoperative pain, wound complication and requirement of analgesic are compared between the two groups.Results:The two groups did not differ in relation to post operative pain. Post operative analgesic requirement are similar in two groups and post operative complications seroma, hematoma, purulent collection are comparable in two groups.Conclusion:Although results are comparable in two groups, electrocautery can be safely used  in making skin incisions as results are comparable in two groups .We recommend further broad  study of electrocautery  usage in other surgical procedure and its further evaluation.Keywords: Electrocautery, Scalpel, Skin incisio

Tin Oxide Nanostructure Fabricated by Thermal Evaporation as Potential NO2 Sensor

Tin oxide (SnO2) gas sensor has been fabricated on glass substrate by using thermal evaporation and further characterize by scanning electron microscopy, atomic force microscopy and EDAX analysis for confirming its morphology and composition. The chemiresistive gas sensing performance of SnO2 films were studied towards various oxidizing and reducing gases. The experimental results reveal that, SnO2 films were vastly sensitive and selective towards NO2 gas than other test gases. SnO2 sensor exhibit maximum response of 160 % for 100 ppm NO2 gas with very fast response time at optimal operating 200 °C temperature. The SnO2 sensor manifests remarkably enhanced sensing performance, including fast response and recovery time, high sensitivity, and good stability, suggests of the promising application in the NO2 gas sensing field

A Validated Densitometric Method for Analysis of Atorvastatin Calcium and Metoprolol Tartarate as Bulk Drugs and In Combined Capsule Dosage Forms

A simple, accurate and precise high-performance thin-layer chromatographic method has been developed for the estimation of Atorvastatin Calcium and Metoprolol Tartarate simultaneously from a capsule dosage form. The method employed Silica gel 60F 254sprecoated plates as stationary phase and a mixture of Chloroform: Methanol: Glacial acetic acid (dil.) :: (9:1.5:0.2 ml %v/v) as mobile phase. Densitometric scanning was performed at 220 nm using Camag TLC scanner 3. The method was linear in the drug concentrations’ range of 500 to 2500 ng/spot for Atorvastatin Calcium, also for Metoprolol Tartarate with correlation coefficient of 0.984 for Atorvastatin Calcium and 0.995 for Metoprolol Tartarate respectively. The retention factor for Atorvastatin Calcium was 0.45 ± 0.04 and for Metoprolol Tartarate was 0.25 ± 0.02. The method was validated as per ICH (International Conference on Harmonisation) Guidelines, proving its utility in estimation of Atorvastatin Calcium and Metoprolol Tartarate in combined dosage form

Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking Agents

The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using formaldehyde and heat treatment. Morphological and physicochemical properties of microspheres were then investigated by scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) spectroscopy. The cross-linking of chitosan takes place at the free amino group because of formation of imine bond as evidenced by FTIR. The DSC, XRD, and FTIR analysis showed that chitosan microspheres cross linked by heating were superior in properties and performance as compared to the microspheres cross-linked using formaldehyde. SEM results revealed that heat-treated microspheres were spherical, discrete having smooth, and porous structure. The particle size and encapsulation efficiencies of the prepared chitosan microspheres ranged between 10.83–24.11 μm and 39.73μ80.56%, respectively. The drug release was extended up to 12 h, and the kinetics of the drug release was obeying Higuchi kinetic proving diffusion-controlled drug release

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding