8,457 research outputs found

    Information Literacy Instruction in an English Capstone Course: A Study of Student Confidence, Perception, and Practice

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    An English professor and an instruction librarian at the University of New Hampshire at Manchester felt that the college\u27s new English Capstone course for majors provided a unique opportunity to assess the information literacy skill levels of graduating English majors. They therefore engaged in a three-year study to evaluate the IL competency of these students, to gauge their perceptions of library instruction provided during the Capstone course and throughout their academic careers, and to determine students\u27 confidence and self-efficacy with respect to these skills. The researchers sought to determine the ways in which the IL program for English majors effectively met established IL goals and to identify areas for improvement

    Self-assembly of multi-component fluorescent molecular logic gates in micelles

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    A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and receptors can result in interesting properties providing cooperative e ffects useful for molecular information processing and other potential applications such as drug delivery systems. This article highlights some of the recent advancements in supramolecular information processing using microheterogeneous media including micelles in aqueous solution.peer-reviewe

    Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types

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    The aim of this study was to examine the gene transfer potential of mef(A)-containing Tn120.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Using the filter mating technique, Tn1207.3 was transferred by conjugation to 23 macrolide-susceptible recipients representing 11 emm types. PCR analysis confirmed the presence of the mef(A) gene and the comEC junction regions of the Tn1207.3 insertion in resultant transconjugants. Significant variation was found in the transfer frequency of Tn1207.3 to different Strep. pyogenes strains, and this phenomenon may contribute to the differences in mef(A) frequency observed among clinical isolates. Significance and Impact of the Study: The spread of antimicrobial resistance among pathogenic bacteria is an important problem, but the mechanisms of horizontal transfer between strains and species are often poorly understood. For instance, little is known on how macrolide resistance spreads between strains of the human pathogen Strep. pyogenes and why certain strains more commonly display resistance than others. Here, we show that Strep. pyogenes strains vary greatly in their ability to acquire a transposon encoding macrolide resistance by horizontal gene transfer in vitro. These data provide a novel insight into the transfer of antibiotic resistance between bacterial strains and offer an explanation for the differences in the frequency of resistance determinates and resistance seen among clinical isolates. © 2014 The Authors Letters in Applied Microbiology

    Partitioning space for range queries

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    It is shown that, given a set S of n points in R3, one can always find three planes that form an eight-partition of S, that is, a partition where at most n/8 points of S lie in each of the eight open regions. This theorem is used to define a data structure, called an octant tree, for representing any point set in R3. An octant tree for n points occupies O(n) space and can be constructed in polynomial time. With this data structure and its refinements, efficient solutions to various range query problems in 2 and 3 dimensions can be obtained, including (1) half-space queries: find all points of S that lie to one side of any given plane; (2) polyhedron queries: find all points that lie inside (outside) any given polyhedron; and (3) circular queries in R2: for a planar set S, find all points that lie inside (outside) any given circle. The retrieval time for all these queries is T(n)=O(na + m) where a= 0.8988 (or 0.8471 in case (3)) and m is the size of the output. This performance is the best currently known for linear-space data structures which can be deterministically constructed in polynomial time

    Three-dimensional microstructuring of yttrium aluminum garnet crystals for laser active optofluidic applications

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    The following article appeared in Applied Physics Letters 103.4 (2013): 041101 and may be found at http://scitation.aip.org/content/aip/journal/apl/103/4/10.1063/1.4816338We demonstrate three-dimensional microstructuring in a neodymium doped yttrium aluminum garnet (Nd:YAG) crystal. Spatially well-defined hollow microstructures deeply embedded within the material are shown to result from the creation of a pre-damage state within the Nd:YAG crystal network that is validated using luminescence and Raman analyses of the structures. This opens up the potential of fabricating next-generation optofluidic devices in optical gain materialsFinancial support from the Spanish Ministerio de EducaciĂłn under the Programa de Movilidad de Recursos Humanos del Plan Nacional de IĂŸDĂŸi 2008/2011 for abroad postdoctoral researchers. This work was also supported by the Universidad AutĂłnoma de Madrid and Comunidad AutĂłnoma de Madrid (Project S2009/MAT- 1756) and by the Spanish Ministerio de EducaciĂłn y Ciencia (MAT2010-16161

    Tunable fibre-coupled multiphoton microscopy with a negative curvature fibre

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    Negative curvature fibre (NCF) guides light in its core by inhibiting the coupling of core and cladding modes. In this work, an NCF was designed and fabricated to transmit ultrashort optical pulses for multiphoton microscopy with low group velocity dispersion (GVD) at 800 nm. Its attenuation was measured to be <0.3 dB m(-1) over the range 600-850 nm and the GVD was -180 ± 70 fs(2)  m(-1) at 800 nm. Using an average fibre output power of ∌20 mW and pulse repetition rate of 80 MHz, the NCF enabled pulses with a duration of <200 fs to be transmitted through a length of 1.5 m of fibre over a tuning range of 180 nm without the need for dispersion compensation. In a 4 m fibre, temporal and spectral pulse widths were maintained to within 10% of low power values up to the maximum fibre output power achievable with the laser system used of 278 mW at 700 nm, 808 mW at 800 nm and 420 mW at 860 nm. When coupled to a multiphoton microscope, it enabled imaging of ex vivo tissue using excitation wavelengths from 740 nm to 860 nm without any need for adjustments to the set-up
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