2,205 research outputs found
Evaluation of Surface State Mediated Charge Recombination in Anatase and Rutile TiO2
In nanostructured thin films, photogenerated charge carriers can access the surface more easily than in dense films and thus react more readily. However, the high surface area of these films has also been associated with enhanced recombination losses via surface states. We herein use transient absorption spectroscopy to compare the ultrafast charge carrier kinetics in dense and nanostructured TiO2 films for its two most widely used polymorphs: anatase and rutile. We find that nanostructuring does not enhance recombination rates on ultrafast timescales, indicating that surface state mediated recombination is not a key loss pathway for either TiO2 polymorph. Rutile shows faster, and less intensity-dependent recombination than anatase, which we assign to its higher doping density. For both polymorphs, we conclude that bulk rather than surface recombination is the primary determinant of charge carrier lifetime
Hierarchical Neural Network Architecture In Keyword Spotting
Keyword Spotting (KWS) provides the start signal of ASR problem, and thus it
is essential to ensure a high recall rate. However, its real-time property
requires low computation complexity. This contradiction inspires people to find
a suitable model which is small enough to perform well in multi environments.
To deal with this contradiction, we implement the Hierarchical Neural
Network(HNN), which is proved to be effective in many speech recognition
problems. HNN outperforms traditional DNN and CNN even though its model size
and computation complexity are slightly less. Also, its simple topology
structure makes easy to deploy on any device.Comment: To be submitted in part to IEEE ICASSP 201
Small Firm Electricity Demand in Las Cruces, New Mexico, USA
Research examining small commercial and industrial electricity usage patterns have historically received less attention than residential electricity consumption patterns. This study examines electricity as an input to small firm commercial and industrial (CIS) production in Las Cruces, the second largest metropolitan economy in the state of New Mexico, using annual frequency data from 1978 to 2018. Those data include labor, per capita personal income, price measures for electricity and natural gas, and weather variables. The long-run and short-run elasticities of the data are then estimated using an autoregressive distributed lag model (ARDL). In the long-run, the CIS derived-demand curve is found to be upward sloping, and Las Cruces CIS customers use natural gas as a complementary input. Real per capita income is also found to have a positive impact in the long-run, while weather impacts are found to be ambiguous. In the short-run, the Las Cruces CIS derived-demand curve is downward sloping, CIS customers use natural gas as a substitute factor, and weather extremes are found to be positively correlated with small firm electricity usage
Avoiding catastrophic failure in correlated networks of networks
Networks in nature do not act in isolation but instead exchange information,
and depend on each other to function properly. An incipient theory of Networks
of Networks have shown that connected random networks may very easily result in
abrupt failures. This theoretical finding bares an intrinsic paradox: If
natural systems organize in interconnected networks, how can they be so stable?
Here we provide a solution to this conundrum, showing that the stability of a
system of networks relies on the relation between the internal structure of a
network and its pattern of connections to other networks. Specifically, we
demonstrate that if network inter-connections are provided by hubs of the
network and if there is a moderate degree of convergence of inter-network
connection the systems of network are stable and robust to failure. We test
this theoretical prediction in two independent experiments of functional brain
networks (in task- and resting states) which show that brain networks are
connected with a topology that maximizes stability according to the theory.Comment: 40 pages, 7 figure
Pulsed Feedback Defers Cellular Differentiation
Environmental signals induce diverse cellular differentiation programs. In certain systems, cells defer differentiation for extended time periods after the signal appears, proliferating through multiple rounds of cell division before committing to a new fate. How can cells set a deferral time much longer than the cell cycle? Here we study Bacillus subtilis cells that respond to sudden nutrient limitation with multiple rounds of growth and division before differentiating into spores. A well-characterized genetic circuit controls the concentration and phosphorylation of the master regulator Spo0A, which rises to a critical concentration to initiate sporulation. However, it remains unclear how this circuit enables cells to defer sporulation for multiple cell cycles. Using quantitative time-lapse fluorescence microscopy of Spo0A dynamics in individual cells, we observed pulses of Spo0A phosphorylation at a characteristic cell cycle phase. Pulse amplitudes grew systematically and cell-autonomously over multiple cell cycles leading up to sporulation. This pulse growth required a key positive feedback loop involving the sporulation kinases, without which the deferral of sporulation became ultrasensitive to kinase expression. Thus, deferral is controlled by a pulsed positive feedback loop in which kinase expression is activated by pulses of Spo0A phosphorylation. This pulsed positive feedback architecture provides a more robust mechanism for setting deferral times than constitutive kinase expression. Finally, using mathematical modeling, we show how pulsing and time delays together enable “polyphasic” positive feedback, in which different parts of a feedback loop are active at different times. Polyphasic feedback can enable more accurate tuning of long deferral times. Together, these results suggest that Bacillus subtilis uses a pulsed positive feedback loop to implement a “timer” that operates over timescales much longer than a cell cycle
Electron Glass in Ultrathin Granular Al Films at Low Temperatures
Quench-condensed granular Al films, with normal-state sheet resistance close
to 10 k, display strong hysteresis and ultraslow, non-exponential
relaxation in the resistance when temperature is varied below 300 mK. The
hysteresis is nonlinear and can be suppressed by a dc bias voltage. The
relaxation time does not obey the Arrhenius form, indicating the existence of a
broad distribution of low energy barriers. Furthermore, large resistance
fluctuations, having a 1/f-type power spectrum with a low-frequency cut-off,
are observed at low temperatures. With decreasing temperature, the amplitude of
the fluctuation increases and the cut-off frequency decreases. These
observations combine to provide a coherent picture that there exists a new
glassy electron state in ultrathin granular Al films, with a growing
correlation length at low temperatures.Comment: RevTeX 3.1, 4 pages, 4 figures (EPS files) (Minor Additions
Higher Education as modulator of gender inequalities: Evidence of the Spanish case
Raising educational levels may help to reduce inequalities between men and women in certain social and economic aspects. Using statistics for Spain, we analyse labour market behaviours such as the rates of activity and unemployment by sex according to the educational level. The results reveal that the differences between men and women decrease as the educational level increases. In particular, the modulator effect of education is very important at the higher level, where differences in labour market behaviour between men and women with an university education almost disappear, except in terms of salaries. Nevertheless, it can be seen that the current economic crisis has reduced the modulator role of education in gender differences in Spain
Filamin C variants are associated with a distinctive clinical and immunohistochemical arrhythmogenic cardiomyopathy phenotype.
BACKGROUND: Pathogenic variants in the filamin C (FLNC) gene are associated with inherited cardiomyopathies including dilated cardiomyopathy with an arrhythmogenic phenotype. We evaluated FLNC variants in arrhythmogenic cardiomyopathy (ACM) and investigated the disease mechanism at a molecular level. METHODS: 120 gene-elusive ACM patients who fulfilled diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC) were screened by whole exome sequencing. Fixed cardiac tissue from FLNC variant carriers who had died suddenly was investigated by histology and immunohistochemistry. RESULTS: Novel or rare FLNC variants, four null and five variants of unknown significance, were identified in nine ACM probands (7.5%). In FLNC null variant carriers (including family members, n = 16) Task Force diagnostic electrocardiogram repolarization/depolarization abnormalities were uncommon (19%), echocardiography was normal in 69%, while 56% had >500 ventricular ectopics/24 h or ventricular tachycardia on Holter and 67% had late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMRI). Ten gene positive individuals (63%) had abnormalities on ECG or CMRI that are not included in the current diagnostic criteria for ARVC. Immunohistochemistry showed altered key protein distribution, distinctive from that observed in ARVC, predominantly in the left ventricle. CONCLUSIONS: ACM associated with FLNC variants presents with a distinctive phenotype characterized by Holter arrhythmia and LGE on CMRI with unremarkable ECG and echocardiographic findings. Clinical presentation in asymptomatic mutation carriers at risk of sudden death may include abnormalities which are currently non-diagnostic for ARVC. At the molecular level, the pathogenic mechanism related to FLNC appears different to classic forms of ARVC caused by desmosomal mutations
ADHD presenting as recurrent epistaxis: a case report
Epistaxis is an important otorhinolaryngological emergency, which usually has an apparent etiology, frequently local trauma in children. Here we present a case report wherein the epistaxis was recalcitrant, and proved to have a psychiatric disorder as an underlying basis. The child was diagnosed with Attention Deficit/Hyperactivity Disorder, hyperactive type, which led to trauma to nasal mucosa due to frequent and uncontrolled nose picking. Treatment with atomoxetine controlled the patient's symptoms and led to a remission of epistaxis
Network Physiology reveals relations between network topology and physiological function
The human organism is an integrated network where complex physiologic
systems, each with its own regulatory mechanisms, continuously interact, and
where failure of one system can trigger a breakdown of the entire network.
Identifying and quantifying dynamical networks of diverse systems with
different types of interactions is a challenge. Here, we develop a framework to
probe interactions among diverse systems, and we identify a physiologic
network. We find that each physiologic state is characterized by a specific
network structure, demonstrating a robust interplay between network topology
and function. Across physiologic states the network undergoes topological
transitions associated with fast reorganization of physiologic interactions on
time scales of a few minutes, indicating high network flexibility in response
to perturbations. The proposed system-wide integrative approach may facilitate
the development of a new field, Network Physiology.Comment: 12 pages, 9 figure
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