Bayesian estimation of physical and geometrical parameters for nanocapacitor array biosensors

8siMassively parallel nanosensor arrays fabricated with low-cost CMOS technology represent powerful platforms for biosensing in the Internet-of-Things (IoT) and Internet-of-Health (IoH) era. They can efficiently acquire “big data” sets of dependable calibrated measure-ments, representing a solid basis for statistical analysis and parameter estimation. In this paper we propose Bayesian estimation methods to extract physical parameters and interpret the statistical variability in the measured outputs of a dense nanocapacitor array biosensor. Firstly, the physical and mathematical models are presented. Then, a simple 1D-symmetry structure is used as a validation test case where the estimated parameters are also known a-priori. Finally, we apply the methodology to the simultaneous extraction of multiple physical and geometrical parameters from measurements on a CMOS pixelated nanocapacitor biosensor platform.reservedmixedStadlbauer, Benjamin; Cossettini, Andrea; Morales E., José A.; Pasterk, Daniel; Scarbolo, Paolo; Taghizadeh, Leila; Heitzinger, Clemens; Selmi, LucaStadlbauer, Benjamin; Cossettini, Andrea; Morales E., José A.; Pasterk, Daniel; Scarbolo, Paolo; Taghizadeh, Leila; Heitzinger, Clemens; Selmi, Luc

Biobanking for Europe

Biobanks are well-organized resources comprising biological samples and associated information that are accessible to scientific investigation. Across Europe, millions of samples with related data are held in different types of collections. While individual collections can be well organized and accessible, the resources are subject to fragmentation, insecurity of funding and incompleteness. To address these issues, a Biobanking and BioMolecular Resources Infrastructure (BBMRI) is to be developed across Europe, thereby implementing a European 'roadmap' for research infrastructures that was developed by a forum of EU member states and that has been received by the European Commission. In this review, we describe the work involved in preparing for the construction of BBMRI in a European and global context