Bragg concentrators for hard (> 10 keV) X-ray astronomy: Status report

The use of focusing telescopes in hard X-ray (E > 10 keV) astronomy will provide better flux sensitivity and imaging perfomances with respect to the directviewing detectors, utilized until now. We present recent results obtained from our Group regarding the possible use of Bragg-diffraction technique to design hard X-ray focusing telescopes

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

We performed in vivo phage display in the stroke prone spontaneously hypertensive rat, a cardiovascular disease model, and the normotensive Wistar Kyoto rat to identify cardiac targeting peptides, and then assessed each in the context of viral gene delivery. We identified both common and strain-selective peptides, potentially indicating ubiquitous markers and those found selectively in dysfunctional microvasculature of the heart. We show the utility of the peptide, DDTRHWG, for targeted gene delivery in human cells and rats in vivo when cloned into the fiber protein of subgroup D adenovirus 19p. This study therefore identifies cardiac targeting peptides by in vivo phage display and the potential of a candidate peptide for vector targeting strategies

The use of airborne remote sensing for benthic cartography: Advantages and reliability

International audienceAirborne remote sensing is a useful tool for the production of biocenosis maps. The use of an image processing system, integrating bathymetric data, makes it possible to considerably refine the charting, through a layer of water of variable thickness and quality. Other limiting factors may have an impact on the quality of results. The identification of these factors makes it possible to propose a scale of reliability. Four examples of aerial teledetection surveys provide the basis for ( i ) assessing the reliability of the maps, ( ii ) determining the reasons for this variation in reliability, and ( iii ) using the scale as a means for assessing the reliability of a given map. The factors used are such that the reliability scale could subsequently be applied to the cartography of other marine assemblages

A compact light readout system for longitudinally segmented shashlik calorimeters

The longitudinal segmentation of shashlik calorimeters is challenged by dead zones and non-uniformities introduced by the light collection and readout system. This limitation can be overcome by direct fiber-photosensor coupling, avoiding routing and bundling of the wavelength shifter fibers and embedding ultra-compact photosensors (SiPMs) in the bulk of the calorimeter. We present the first experimental test of this readout scheme performed at the CERN PS-T9 beamline in 2015 with negative particles in the 1-5~GeV energy range. In this paper, we demonstrate that the scheme does not compromise the energy resolution and linearity compared with standard light collection and readout systems. In addition, we study the performance of the calorimeter for partially contained charged hadrons to assess the $e/\pi$ separation capability and the response of the photosensors to direct ionization.Comment: To appear in Nuclear Instruments and Methods in Physics Research,