How ethnic and linguistic heterogeneity influence the prospects for civil society: A comparative study of citizenship behavior

While the positive consequences of social capital and civil society are widely accepted and appreciated, the question of how they originate and can be sustained has received relatively little attention from scholars. In this study, we approach this question from a cross-national and individual-level perspective by examining how population heterogeneity in the form of ethnic and linguistic diversity affects citizenship behavior, measured by cognitive and interpersonal engagement about politics, membership in voluntary associations, and interpersonal trust. Based on data collected in 44 countries, our analyses show that heterogeneity does affect the quality of civil society in a country. However, indicators of population heterogeneity do not have uniformly positive or negative effects on individual-level measures of civil society - while they reduce some, they shore up others. © 2006 Southern Political Science Association

In the eye of the beholder? The foundations of subjective human rights conditions in East-Central Europe

Using cross-national survey data and information on government practices concerning human rights collected in 17 post-Communist states in Central and Eastern Europe, the authors examine the determinants of people's attitudes about their country's human rights situation. They find that not all people in countries that systematically violate human rights develop more negative opinions about their country's human rights situation. However, results show high levels of disregard for human rights strongly affect evaluations of human rights practices among individuals with higher levels of education. Thus better educated respondents were significantly more likely to say there was respect for human rights in their country if they lived in a country with fewer violations of the integrity of the person or that protected political and civil rights; conversely, they were less likely to say so if they lived in a more repressive country or a country where political and civil rights were frequently violated. © 2005 Sage Publications

Psychometric validation of the European Organisation for Research and Treatment of Cancer–Quality of Life Questionnaire Sexual Health (EORTC QLQ-SH22)

BACKGROUND: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group developed a questionnaire to assess sexual health in patients with cancer and cancer survivors. This study evaluates the psychometric properties of the questionnaire. METHODS: The 22-item EORTC sexual health questionnaire (EORTC QLQ-SH22) was administered with the EORTC QLQ-C30 to 444 patients with cancer. The hypothesised scale structure, reliability and validity were evaluated through standardised psychometric procedures. RESULTS: The cross-cultural field study showed that the majority of patients (94.7%) were able to complete the QLQ-SH22 in less than 20 min; 89% of the study participants did not need any help to fill in the questionnaire. Multi-item multi-trait scaling analysis confirmed the hypothesised scale structure with two multi-item scales (sexual satisfaction, sexual pain) and 11 single items (including five conditional items and four gender-specific items). The internal consistency yielded acceptable Cronbach's alpha coefficients (.90 for the sexual satisfaction scale, .80 for the sexual pain scale). The test-retest correlations (Pearson's r) ranged from .70 to .93 except for the scale communication with professionals (.67) and male body image (.69). The QLQ-SH22 discriminates well between subgroups of patients differing in terms of their performance and treatment status. CONCLUSION: The study supports the reliability, the content and construct validity of the QLQ-SH22. The newly developed questionnaire is clinically applicable to assess sexual health of patients with cancer at different treatment stages and during survivorship for clinical trials and for clinical practice

Phase II trial of tamoxifen and goserelin in recurrent epithelial ovarian cancer

Endocrine therapy is a recognised option in the treatment of chemo-resistant ovarian cancer. We conducted a nonrandomised phase II evaluation of combination endocrine therapy with tamoxifen and goserelin in patients with advanced ovarian cancer that had recurred following chemotherapy. In total, 26 patients entered the study, of which 17 had platinum-resistant disease. The median age was 63 years and enrolled patients had received a median of three chemotherapy regimens prior to trial entry. Patients were given oral tamoxifen 20 mg twice daily on a continuous basis and subcutaneous goserelin 3.6 mg once a month until disease progression. Using the definition of endocrine response that included patients with stable disease (SD) of 6 months or greater, the overall response rate (clinical benefit rate) was 50%. This included one complete response (CR) (3.8%), two partial responses (PR) (7.7%) and 10 patients with SD (38.5%). The median progression-free interval (PFI) was 4 months (95% CI 2.4–9.6) while the median overall survival (OS) was 13.6 months (95% CI 5.5–30.6). Four patients received treatment for more than 2 years (range 1–31) and one of them is still on treatment. In none of the four patients was there any evidence of recurrent or cumulative treatment related toxicity. Treatment-limiting toxicity was not seen in any of the study population. Endocrine data demonstrated a marked suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH) to less than 4% of baseline values. No consistent correlation could be established between LH/FSH suppression and tumour response. Likewise no relationship was observed between Inhibin A/B and pro-alpha C levels and tumour response. Inhibin is unlikely to be a useful surrogate marker for response in locally advanced or metastatic ovarian cancer. Combination endocrine therapy with tamoxifen and goserelin is an active regimen in platinum-resistant ovarian cancer patients. Hormonal therapy is advantageous in its relative lack of toxicity, ease of administration and tolerability, thus making it suitable for patients with heavily pretreated disease, compromised bone marrow function and other comorbid conditions that contraindicate cytotoxic therapy as well as in patients with indolent disease

Citizen Satisfaction With Democracy and Parties’ Policy Offerings

The authors examine the relationship between the variation of policy choices on offer in a party system and citizen satisfaction. Cross-national analyses, based on 12 countries from 1976 to 2003, are presented that suggest that when party choices in a political system are more ideologically proximate to the mean voter position in left–right terms, overall citizen satisfaction increases. The central implication of this finding is that party positions matter for understanding within-country changes in satisfaction. </jats:p