Machinability study on drilling austenite stainless steel 316l1 using minimum quantity lubrication (MQL) on surface roughness

This research was carried out to determine the optimum condition of cutting speed, feed rate and point of angle while drilling the austenite stainless steel in order to get the good surface finish by using Minimum Quantity Lubrication (MQL). This project focuses on the drilling small hole on the austenite stainless steel by using milling machine. The aim of this project is to find the optimum condition in producing the good surface finish in drilling process with MQL. The Taguchi OA from software Minitab 16 was used to formulate the experiment, to analyze the three factors and also to predict the optimal choices of the drilling parameters. The selected cutting speeds for the drilling process are 15m/min, 25m/min and 35m/min. For the feed rate, the parameters are 0.1mm/rev, 0.15mm/rev and 0.2mm/rev. The third parameter that will be considered in this project is point of angle, and the parameters that will be used are about 110°, 120° and 135°. The machining processes were performed on the CNC milling machine. The surface roughness will be test by using Surfcom 130A. Results shows that, the best surface roughness were obtained at the lower cutting speed, middle of feed rate and middle of point of angle. So, the optimum cutting speed, feed rate and point of angle are, 15m/min, 0.15mm/rev and 120°. The confirmation results show that, the predicted values and the measured values are quite close to each other

How Robust Is Discourse Processing for Native Readers? The Role of Connectives and the Coherence Relations They Convey.

While corpus studies have shown that discourse connectives that convey the same coherence relation can display subtle differences, research on online discourse processing has only focused on a rather limited set of connectives. Yet, different connectives - for example, rare or polyfunctional ones - might elicit different reading patterns. In order to explore this assumption, we test the robustness of discourse processing for French native speakers by measuring the way they process causal and concessive sentences that are conveyed by either an appropriate or inappropriate connective. Throughout three experiments, we change important characteristics of the connectives: we first test frequently used connectives (Experiment 1), secondly less frequent ones (Experiment 2), and finally less frequent connectives that are polyfunctional and for which different functions clearly compete (Experiment 3). Our results show that the processing for incoherent items was affected for all connectives, however readers showed altered reading fluency when infrequent connectives were used. We conclude that discourse processing is quite robust and that readers are able to insert meaning conveyed by rare connectives while still showing the highest reading ease with frequent connectives

Individual Variations in the Mastery of Discourse Connectives from Teenage Years to Adulthood

Many connectives, such as therefore and however, are used very frequently in the written modality. Their acquisition thus represents an important milestone in developing written language competences. In this article, we assess the development of competence with such connectives by native French speakers in a sentence-level insertion task (N = 307, aged 12 to 64) and a text-level insertion task (N = 172, aged 13 to 71). Our results indicate that, despite a general progression in the level of competence with age, the academic level of participants is a strong predictor of competence within each age group, even during adulthood. In addition, from the age of 12, competence is related to the frequency of connectives in naturalistic data, with frequent connectives systematically mastered better than less frequent ones. Finally, in all age groups, the use and understanding of connectives is more challenging when sentences to complete are embedded within a richer context than when presented alone

Pragmatic and syntactic constraints on French causal connectives: An evaluation of native and non-native speakers' sensitivity.

When writing a text, the choice between seemingly equivalent connectives, such as but and however, is not arbitrary: aside from preferences linked to the register or modality of the utterance, there are often pragmatic or syntactic constraints that limit the choice to only one particular connective. For French, theoretical approaches have extensively discussed the syntactic and pragmatic constraints that allow only either parce que (‘because’) or puisque (‘since’). However, experimental findings regarding the actual sensitivity of French speakers to these constraints remain inconclusive. In the current study, we examine the sensitivity of different speaker groups to the constraints associated with the use of parce que and puisque. In a controlled offline-task, we systematically evaluate the sensitivity of a crowd-sourced heterogeneous group of native speakers (Experiment 1) and a group of non-native speakers (Experiment 2). Results show that native speakers are more sensitive to syntactic constraints whereas pragmatic constraints are more equivocal. Nonnative speakers, however, are not sensitive to either of these constraints. In addition, the pragmatically complex connective puisque is extremely problematic for non-native speakers, as even the mapping of a seemingly equivalent connective of their L1 did not warrant a good mastery of its pragmatic functions

Impact of obesity on the response to tumor necrosis factor inhibitors in axial spondyloarthritis.

Few studies have investigated the impact of obesity on the response to tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). The aim of our study was to investigate the impact of different body mass index (BMI) categories on TNFi response in a large cohort of patients with axSpA. Patients with axSpA within the Swiss Clinical Quality Management (SCQM) program were included in the current study if they fulfilled the Assessment in Spondyloarthritis International Society (ASAS) criteria for axSpA, started a first TNFi after recruitment, and had available BMI data as well as a baseline and follow-up visit at 1 year (±6 months). Patients were categorized according to BMI: normal (BMI 18.5 to <25), overweight (BMI 25-30), and obese (BMI >30). We evaluated the proportion of patients achieving the 40% improvement in ASAS criteria (ASAS40), as well as Ankylosing Spondylitis Disease Activity Score (ASDAS) improvement and status scores at 1 year. Patients having discontinued the TNFi were considered nonresponders. We controlled for age, sex, HLA-B27, axSpA type, BASDAI, BASMI, elevated C-reactive protein (CRP), current smoking, enthesitis, physical exercise, and co-medication with disease-modifying antirheumatic drugs, as well as with nonsteroidal anti-inflammatory drugs in multiple adjusted logistic regression analyses. A total of 624 axSpA patients starting a first TNFi were considered in the current study (332 patients of normal weight, 204 patients with overweight, and 88 obese patients). Obese individuals were older, had higher BASDAI levels, and had a more important impairment of physical function in comparison to patients of normal weight, while ASDAS and CRP levels were comparable between the three BMI groups. An ASAS40 response was reached by 44%, 34%, and 29% of patients of normal weight, overweight, and obesity, respectively (overall p = 0.02). Significantly lower odds ratios (ORs) for achieving ASAS40 response were found in adjusted analyses in obese patients versus patients with normal BMI (OR 0.27, 95% confidence interval (CI) 0.09-0.70). The respective adjusted ASAS40 OR in overweight versus normal weight patients was 0.62 (95% CI 0.24-1.14). Comparable results were found for the other outcomes assessed. Obesity is associated with significantly lower response rates to TNFi in patients with axSpA

The masculine bias in fully gendered languages and ways to avoid it: A study on gender neutral forms in Québec and Swiss French.

The extent to which gender neutral and gendered nouns impact differently upon native French speakers’ gender representations was examined through a yes-no forced choice task. Swiss (Experiment 1) and Québec (Experiment 2) French-speaking participants were presented with word pairs composed of a gendered first name (e.g., Thomas) and a role (e.g., doctor), and tasked to indicate whether they believed that [first name] could be one of the [role]. Roles varied according to gender stereotypicality (feminine, masculine, non-stereotyped), and were either in a plural masculine (interpretable as generic) or gender neutral (epicenes and group nouns) form. The results indicated that the use of gender neutral forms of roles avoided a strong male bias found for the masculine forms, and that both gender neutral and masculine forms used equal cognitive resources. Further, stereotype effects associated with both gender-neutral and grammatically masculine forms were quite small (<1%). These results were highly reliable across both Swiss French and Québec speakers. Our study suggests that gender neutral forms are strong alternatives to the use of the masculine form as default value

Surgical management of abdominal and retroperitoneal Castleman's disease

BACKGROUND: Abdominal and retroperitoneal Castleman's disease could present either as a localized disease or as a systemic disease. Castleman's disease is a lymphoid hyperplasia related to human Herpes virus type 8, which could have an aggressive behavior, similar to that of malignant lymphoid neoplasm mainly with the systemic type, or a benign one in its localized form. METHODS: The authors report two cases of localized Castleman's disease in the retroperitoneal space and review the current and recent progress in the knowledge of this atypical disease. CASES PRESENTATION: The two patients were young healthy women presenting with a hyper vascular peri-renal mass suggestive of malignant tumor. Both have been resected in-toto. One of them had an extensive resection with nephrectomy, while the second had a kidney preserving surgery. Pathological examination revealed localized Castleman's disease and surgical margins were free of disease. Postoperative course was uneventful, and after more than 5-years of follow-up no recurrences have been observed. CONCLUSION: Localized Castleman's disease should be considered when facing a solid hypervascular abdominal or retroperitoneal mass. A better knowledge of this disorder and its characteristic would help surgeon to avoid unnecessarily extensive resection for this benign disorder when dealing with abdominal or retroperitoneal tumors. Surgical resection is curative for the localized form, when complete, while splenectomy could be indicated for the systemic form

A canvas for the ethical design of learning experiences with digital tools

The use of digital tools has drastically increased in engineering education, accelerated by the COVID-19 pandemic. These tools generate important ethical issues, in particular in terms of privacy and fairness. However, very few teacher training programmes address those topics, which means that teachers are often left to figure out by themselves how to address these issues when they want (or have) to use digital tools in their teaching. In this workshop, participants will be introduced to a pragmatic approach to the ethical design of learning experiences that involve digital tools using a visual thinking guide called a ‘canvas’. Applied and hands-on, this workshop will help participants to develop a practical understanding of the specific ethical issues related to the use of digital tools in teaching and to integrate ethical reflection into design processes when digital technology is involved