Building a Better RAFT: Improving Access to Emergency Rental Assistance in Massachusetts

The Residential Assistance for Families in Transition program, better known as RAFT, is a vital lifeline for thousands of families each year who find themselves in danger of homelessness. It provides temporary housing resources to thousands of families each year, thanks to the critical partnership of community-based organizations (CBOs) and regional administrators, who make the complicated system easier for recipients. But could RAFT be more effective? The answer is unequivocally yes. In this report, four organizations with experience in the housing sector - TBF, CHAPA, the Metropolitan Area Planning Council and the United Way of Massachusetts Bay - draw up a list of policy recommendations that could make resources easier to access and more available to families in need.In addition to increasing funding, the brief calls for efforts to simplify and streamline a fragmented system, reduce burdens on applicants for RAFT, and provide resources and other supports for CBOs to better serve applicants throughout the process

Climate Variability in Europe and Africa: a PAGES-PEP III Time Stream II Synthesis

The PEP III Europe-Africa transect extends from the arctic fringes of NW Eurasia to South Africa. It encompasses the presently temperate sector of mid-latitude Europe, the Mediterranean region, the arid and semi-arid lands of the Sahara, Sahel and the Arabian Peninsula, and the inter-tropical belt of Africa. The palaeoenvironmental evidence available from these regions, which has been summarised in earlier chapters of this volume and which collectively spans the last 250,000 years, clearly bears the stamp of long-term global climate forcing induced by variations in solar insolation. External forcing is ultimately the reason why the Eurasian continental ice sheets waxed and waned repeatedly during the late Quaternary, and why the southerly limit of permafrost migrated southwards across mid-latitude Europe, periodically becoming degraded during warmer episodes. At the same time, pronounced fluctuations in atmospheric and soil moisture have affected the Mediterranean, desert and Sahel regions, while there is abundant evidence from every sector of the PEP III transect for marked migrations of the principal vegetation belts, as well as for other major environmental changes, that are also considered to reflect long-term climate forcing. It is only in the last decade or so, however, that the full complexity of the history of climate changes during the last interglacial-glacial cycle, and their environmental impacts in continental Europe and Africa, have begun to be recognised. The discovery of evidence for the abrupt Dansgaard-Oeschger (D-O) and Heinrich (H) climatic oscillations in Greenland ice-core (Johnsen et al. 1992) and North Atlantic (Bond et al. 1993) records, have prompted a re-examination of the continental record. This, together with a number of technical improvements in field and laboratory equipment, greater access to sites in remote and difficult terrain, diversification in the range of available palaeoecological and geochronological tools, and closer inter-disciplinary collaboration, have led to a more penetrating examination of the field evidence, which has progressed the science considerably. We can now see that the stratigraphical record is much more complex than appreciated hitherto, and more detailed and refined models of past climatic and environmental models are beginning to emerge. There is, for example, a growing body of evidence which suggests that D-O and H events had significant impacts on the environment of Europe and Africa, as well as on the Mediterranean Sea

Pre-main-sequence isochrones -- I. The Pleiades benchmark

We present a critical assessment of commonly used pre-main-sequence isochrones by comparing their predictions to a set of well-calibrated colour-magnitude diagrams of the Pleiades in the wavelength range 0.4 to 2.5 microns. Our analysis shows that for temperatures less than 4000 K the models systematically overestimate the flux by a factor two at 0.5 microns, though this decreases with wavelength, becoming negligible at 2.2 microns. In optical colours this will result in the ages for stars younger than 10 Myr being underestimated by factors between two and three. We show that using observations of standard stars to transform the data into a standard system can introduce significant errors in the positioning of pre-main-sequences in colour-magnitude diagrams. Therefore we have compared the models to the data in the natural photometric system in which the observations were taken. Thus we have constructed and tested a model of the system responses for the Wide-Field Camera on the Isaac Newton Telescope. As a benchmark test for the development of pre-main-sequence models we provide both our system responses and the Pleiades sequence.Comment: 15 pages, 12 figures, 7 tables, accepted for publication in MNRAS. All tables are available online at the Cluster Collaboration homepage http://www.astro.ex.ac.uk/people/timn/Catalogues

EVIDENCE FOR OVERDOMINANT SELECTION MAINTAINING X-LINKED FITNESS VARIATION IN DROSOPHILA MELANOGASTER

The role of balancing selection in maintaining genetic variation for fitness is largely unresolved. This reflects the inherent difficult in distinguishing between models of recurrent mutation versus selection, which produce similar patterns of inbreeding depression, as well as the limitations of testing such hypotheses when fitness variation is averaged across the genome. Signatures of X-linked overdominant selection are less likely to be obscured by mutational variation because X-linked mutations are rapidly eliminated by purifying selection in males. Although models maintaining genetic variation for fitness are not necessarily mutually exlusive, a series of predictins for identifying X-linked overdominant selection can be used to separate its contribution from other underlying processes. We consider the role of overdominant selection in maintaining fitness variation in a sample of 12 X chromosomes from a population of Drosophila melanogaster. Substantial variation was observed for male reproductive success and female fecundity, with heterozygous-X genotypes exhibiting the greatest gegree of variance, a finding that agress well with predictions of the overdominance model. The importance of X-linked overdominant selection is discussed along with models of recurrent mutation and sexually antagonistic selection.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75442/1/j.0014-3820.2006.tb01223.x.pd

Demographics of extra-articular calcaneal fractures: Including a review of the literature on treatment and outcome

Introduction: Extra-articular calcaneal fractures represent 25-40% of all calcaneal fractures and an even higher percentage of up to 60% is seen in children. A disproportionately small part of the literature on calcaneal fractures involves the extra-articular type. The aim of this study was to investigate the incidence of extra-articular calcaneal fractures in a Level 1 trauma centre, define the distribution of the various types of fractures and compare patient demographics between extra- and intra-articular calcaneal fractures. In addition the literature was reviewed for the most common types of extra-articular calcaneal fractures with regard to incidence, treatment and clinical outcome. Methods: The radiological records between 2003 and 2005 were reviewed for intra- and extra-articular calcaneal fractures. Patient gender-distribution and age were compared. A literature search was conducted for the treatment of extra-articular calcaneal fractures. Results: In this 3-year study period a total of 49 patients with 50 extra-articular calcaneal fractures and 91 patients with 101 intra-articular fractures were identified. The median age for the first group was 32.7 years, and for the second group 40.3 years; P = 0.04. Male predominance was significantly less pronounced for extra-articular (63%) compared with intra-articular fractures (79%; P = 0.04). Conclusion: One-third of all calcaneal fractures are extra-articular. Significant differences exist between the intra- and extra-articular groups, in terms of lower age and male-female ratio. The literature study shows inconsistencies in treatment options, but most extra-articular fractures are well manageable conservatively

Association between a variation in the phosphodiesterase 4D gene and bone mineral density

BACKGROUND: Fragility fractures caused by osteoporosis are a major cause of morbidity and mortality in aging populations. Bone mineral density (BMD) is a useful surrogate marker for risk of fracture and is a highly heritable trait. The genetic variants underlying this genetic contribution are largely unknown. METHODS: We performed a large-scale association study investigating more than 25,000 single nucleotide polymorphisms (SNPs) located within 16,000 genes. Allele frequencies were estimated in contrasting DNA pools from white females selected for low (<0.87 g/cm(2), n = 319) and high (> 1.11 g/cm(2), n = 321) BMD at the lumbar spine. Significant findings were verified in two additional sample collections. RESULTS: Based on allele frequency differences between DNA pools and subsequent individual genotyping, one of the candidate loci indicated was the phosphodiesterase 4D (PDE4D) gene region on chromosome 5q12. We subsequently tested the marker SNP, rs1498608, in a second sample of 138 white females with low (<0.91 g/cm(2)) and 138 females with high (>1.04 g/cm(2)) lumbar spine BMD. Odds ratios were 1.5 (P = 0.035) in the original sample and 2.1 (P = 0.018) in the replication sample. Association fine mapping with 80 SNPs located within 50 kilobases of the marker SNP identified a 20 kilobase region of association containing exon 6 of PDE4D. In a second, family-based replication sample with a preponderance of females with low BMD, rs1498608 showed an opposite relationship with BMD at different sites (p = 0.00044-0.09). We also replicated the previously reported association of the Ser37Ala polymorphism in BMP2, known to interact biologically with PDE4D, with BMD. CONCLUSION: This study indicates that variants in the gene encoding PDE4D account for some of the genetic contribution to bone mineral density variation in humans. The contrasting results from different samples indicate that the effect may be context-dependent. PDE4 inhibitors have been shown to increase bone mass in normal and osteopenic mice, but up until now there have been no reports implicating any member of the PDE4 gene family in human osteoporosis

The Woody Guthrie Centennial Bibliography

This bibliography updates two extensive works designed to include comprehensively all significant works by and about Woody Guthrie. Richard A. Reuss published A Woody Guthrie Bibliography, 1912–1967 in 1968 and Jeffrey N. Gatten\u27s article “Woody Guthrie: A Bibliographic Update, 1968–1986” appeared in 1988. With this current article, researchers need only utilize these three bibliographies to identify all English-language items of relevance related to, or written by, Guthrie

Seroprevalence of 34 Human Papillomavirus Types in the German General Population

The natural history of infections with many human papillomavirus (HPV) types is poorly understood. Here, we describe for the first time the age- and sex-dependent antibody prevalence for 29 cutaneous and five mucosal HPV types from 15 species within five phylogenetic genera (alpha, beta, gamma, mu, nu) in a general population. Sera from 1,797 German adults and children (758 males and 1,039 females) between 1 and 82 years (median 37 years) were analysed for antibodies to the major capsid protein L1 by Luminex-based multiplex serology. The first substantial HPV antibody reactions observed already in children and young adults are those to cutaneous types of the genera nu (HPV 41) and mu (HPV 1, 63). The antibody prevalence to mucosal high-risk types, most prominently HPV 16, was elevated after puberty in women but not in men and peaked between 25 and 34 years. Antibodies to beta and gamma papillomaviruses (PV) were rare in children and increased homogeneously with age, with prevalence peaks at 40 and 60 years in women and 50 and 70 years in men. Antibodies to cutaneous alpha PV showed a heterogeneous age distribution. In summary, these data suggest three major seroprevalence patterns for HPV of phylogenetically distinct genera: antibodies to mu and nu skin PV appear early in life, those to mucosal alpha PV in women after puberty, and antibodies to beta as well as to gamma skin PV accumulate later in life

Recurrent seasonal outbreak of an emerging serotype of Shiga toxin-producing Escherichia coli (STEC O55:H7 Stx2a) in the south west of England, July 2014 to September 2015.

The first documented British outbreak of Shiga toxin-producing Escherichia coli (STEC) O55:H7 began in the county of Dorset, England, in July 2014. Since then, there have been a total of 31 cases of which 13 presented with haemolytic uraemic syndrome (HUS). The outbreak strain had Shiga toxin (Stx) subtype 2a associated with an elevated risk of HUS. This strain had not previously been isolated from humans or animals in England. The only epidemiological link was living in or having close links to two areas in Dorset. Extensive investigations included testing of animals and household pets. Control measures included extended screening, iterative interviewing and exclusion of cases and high risk contacts. Whole genome sequencing (WGS) confirmed that all the cases were infected with similar strains. A specific source could not be identified. The combination of epidemiological investigation and WGS indicated, however, that this outbreak was possibly caused by recurrent introductions from a local endemic zoonotic source, that a highly similar endemic reservoir appears to exist in the Republic of Ireland but has not been identified elsewhere, and that a subset of cases was associated with human-to-human transmission in a nursery