Oral History Interview: Kenny Partlow

This interview is one of a series conducted with former employees of the Huntington Owens-Illinois, Inc. glass bottle factory. Kenny Partlow was an employee at the Owens Illinois glass plant. He discusses: his employment history (at Owens Illinois and elsewhere); different jobs and duties at the plant; labor unions (including one that Mr. Partlow was president of); strikes and lockouts; machines taking jobs from employees; individuals such as Denny Silvis (a plant manager), Opal Mann, Kitty Dukakis, & Senator Ned Jones; the closing of the plant; racial & gender integration at the plant some discussion of politics; a very brief section on eating buffalo/beefalo; sports (mainly boxing); his views on Huntington, WV; and economics.https://mds.marshall.edu/oral_history/1425/thumbnail.jp

Sodium Channel SCN3A (Na(V)1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development

Channelopathies are disorders caused by abnormal ion channel function in differentiated excitable tissues. We discovered a unique neurodevelopmental channelopathy resulting from pathogenic variants in SCN3A, a gene encoding the voltage-gated sodium channel Na(V)1.3. Pathogenic Na(V)1.3 channels showed altered biophysical properties including increased persistent current. Remarkably, affected individuals showed disrupted folding (polymicrogyria) of the perisylvian cortex of the brain but did not typically exhibit epilepsy; they presented with prominent speech and oral motor dysfunction, implicating SCN3A in prenatal development of human cortical language areas. The development of this disorder parallels SCN3A expression, which we observed to be highest early in fetal cortical development in progenitor cells of the outer subventricular zone and cortical plate neurons and decreased postnatally, when SCN1A (Na(V)1.1) expression increased. Disrupted cerebral cortical folding and neuronal migration were recapitulated in ferrets expressing the mutant channel, underscoring the unexpected role of SCN3A in progenitor cells and migrating neurons.Peer reviewe