On Rigidity of 3d Asymptotic Symmetry Algebras

We study rigidity and stability of infinite dimensional algebras which are not subject to the Hochschild-Serre factorization theorem. In particular, we consider algebras appearing as asymptotic symmetries of three dimensional spacetimes, the BMS3, u(1) Kac-Moody and Virasoro algebras. We construct and classify the family of algebras which appear as deformations of BMS3, u(1) Kac-Moody and their central extensions by direct computations and also by cohomological analysis. The Virasoro algebra appears as a specific member in this family of rigid algebras; for this case stabilization procedure is inverse of the In\"on\"u-Wigner contraction relating Virasoro to BMS3 algebra. We comment on the physical meaning of deformation and stabilization of these algebras and relevance of the family of rigid algebras we obtainComment: 50 pages, one figure and two tables; v2: minor improvements, references adde

Modification of as-cast Al-Mg/B4C composite by addition of Zr

Zirconium was used in Al-Mg/B4C composite to improve compocasting efficiency by increasing particle incorporation. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) results revealed that by addition of zirconium a reaction layer containing Zr, Al, B and C is formed on the interface of B4C-matrix. X-ray diffraction (XRD) analysis of extracted particles unveiled that the ZrB2 phase is the main constituent of this layer. Formation of ZrB2 is an exothermic reaction which can rise temperature locally around particles and agglomerates. Rising temperature around agglomerates in conjunction with turbulent flow of melt facilitates agglomerates wetting and dissolving into molten aluminum. As the result, final product contains more uniformly distributed B4C particles. Besides enhancing compocasting efficiency, addition of Zr and formation of reaction layer by improving particle matrix bonding quality, led to increase in ultimate tensile strength and elongation of the composite around 8% and 30%, respectively. SEM observations of the fracture surfaces confirmed that a proper bonding presents at the interface of particles and matrix in presence of Zr.Peer ReviewedPostprint (author's final draft

Shave excision of facial tumors in tuberous sclerosis.

Tuberous sclerosis can manifest itself by multiple facial nodules affecting primarily the nose, cheeks, chin, and the nasolabial folds. A simple tangential (shave) excision of these facial tumors is believed to be adequate treatment for some patients

‘Smart’ sustainable urban regeneration: Institutions, quality and financial innovation

Cities around the world are under pressure from population growth, frenetic global economic restructuring, and climatic perturbations. Some, like London, attract an excess of speculative, momentum or tax-informed inward investment to finance their intensification. Provincial towns, on the other hand, which sustain extractive metropolii, can wither without capital or talent. Sensible planning and calibrated regional investment is the antidote to polarisation but confronts an apparent ‘smart’ or ‘sustainable’ conundrum. Grandiose, technical megaprojects like Songdo or Masdar cities and sprawling, disconnected estates are an anathema. We articulate a putative smart and sustainable solution (‘smart-SUR’) with ‘institutional’, ‘project’ and innovative ‘funding’ components and explore mega-urban regeneration projects in the UK and Holland. Smart-SUR has geographical, procedural and teleological aspects. Its mechanism involves local engagement, institutional strengthening, tight project screening and innovative regenerative funding. Its outcome are inclusive, measured, and coordinated transformations which ‘sweat’ existing assets, counter the long-tail of educational failure, and catalyse productive local innovation

Asynchronous Execution of Python Code on Task Based Runtime Systems

Despite advancements in the areas of parallel and distributed computing, the complexity of programming on High Performance Computing (HPC) resources has deterred many domain experts, especially in the areas of machine learning and artificial intelligence (AI), from utilizing performance benefits of such systems. Researchers and scientists favor high-productivity languages to avoid the inconvenience of programming in low-level languages and costs of acquiring the necessary skills required for programming at this level. In recent years, Python, with the support of linear algebra libraries like NumPy, has gained popularity despite facing limitations which prevent this code from distributed runs. Here we present a solution which maintains both high level programming abstractions as well as parallel and distributed efficiency. Phylanx, is an asynchronous array processing toolkit which transforms Python and NumPy operations into code which can be executed in parallel on HPC resources by mapping Python and NumPy functions and variables into a dependency tree executed by HPX, a general purpose, parallel, task-based runtime system written in C++. Phylanx additionally provides introspection and visualization capabilities for debugging and performance analysis. We have tested the foundations of our approach by comparing our implementation of widely used machine learning algorithms to accepted NumPy standards

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire tolerance to antifungal drugs and for nonmeiotic ploidy reduction after mating. We discovered that the ancestor of C. albicans and 2 related pathogens evolved a variant of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kinase, a key regulator of chromosome segregation. Using engineered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the fidelity of chromosome segregation and the rate of acquisition of tolerance to antifungal drugs via aneuploidy. Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. We conclude that genetically programmed and environmentally induced changes in chromatin can confer the capacity for enhanced evolvability via chromosome missegregation

Decay Modes of Unstable Strings in Plane-Wave String Field Theory

The cubic interaction vertex of light-cone string field theory in the plane-wave background has a simple effective form when considering states with only bosonic excitations. This simple effective interaction vertex is used in this paper to calculate the three string interaction matrix elements for states of arbitrary bosonic excitation and these results are used to examine certain decay modes on the mass-shell. It is shown that the matrix elements of one string to two string decays involving only bosonic excitations will vanish to all orders in 1/mu on the mass-shell when the number of excitations on the initial string is less than or equal to two, but in general will not vanish when the number of excitations is greater than two. Also, a truncated calculation of the mass-shell matrix elements for one string to three string decays of two excitation states is performed and suggests that these matrix elements do not vanish on the mass-shell. There is, however, a quantitative discrepancy between this last result and its (also non-vanishing) gauge theory prediction from the BMN correspondence.Comment: 11 pages; v2: references added; v3: normalization of interaction vertex and corresponding amplitudes changed by a factor of mu to reflect SFT normalization (must now divide by mu to compare with BMN dual gauge theory), and minor errors correcte

A Scalable Correlator Architecture Based on Modular FPGA Hardware, Reuseable Gateware, and Data Packetization

A new generation of radio telescopes is achieving unprecedented levels of sensitivity and resolution, as well as increased agility and field-of-view, by employing high-performance digital signal processing hardware to phase and correlate large numbers of antennas. The computational demands of these imaging systems scale in proportion to BMN^2, where B is the signal bandwidth, M is the number of independent beams, and N is the number of antennas. The specifications of many new arrays lead to demands in excess of tens of PetaOps per second. To meet this challenge, we have developed a general purpose correlator architecture using standard 10-Gbit Ethernet switches to pass data between flexible hardware modules containing Field Programmable Gate Array (FPGA) chips. These chips are programmed using open-source signal processing libraries we have developed to be flexible, scalable, and chip-independent. This work reduces the time and cost of implementing a wide range of signal processing systems, with correlators foremost among them,and facilitates upgrading to new generations of processing technology. We present several correlator deployments, including a 16-antenna, 200-MHz bandwidth, 4-bit, full Stokes parameter application deployed on the Precision Array for Probing the Epoch of Reionization.Comment: Accepted to Publications of the Astronomy Society of the Pacific. 31 pages. v2: corrected typo, v3: corrected Fig. 1