5,617 research outputs found
A multifractal zeta function for cookie cutter sets
Starting with the work of Lapidus and van Frankenhuysen a number of papers
have introduced zeta functions as a way of capturing multifractal information.
In this paper we propose a new multifractal zeta function and show that under
certain conditions the abscissa of convergence yields the Hausdorff
multifractal spectrum for a class of measures
From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments
Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus. Members of the family include the industrially important species Lactococcus lactis, which has a long history safe use in the fermentative food industry, and the disease-causing streptococci Streptococcus pneumoniae and Streptococcus pyogenes. The central metabolic pathways of the Streptococcaceae family have been extensively studied because of their relevance in the industrial use of some species, as well as their influence on virulence of others. Recent developments in high-throughput proteomic and DNA-microarray techniques, in in vivo NMR studies, and importantly in whole-genome sequencing have resulted in new insights into the metabolism of the Streptococcaceae family. The development of cost-effective high-throughput sequencing has resulted in the publication of numerous whole-genome sequences of lactococcal and streptococcal species. Comparative genomic analysis of these closely related but environmentally diverse species provides insight into the evolution of this family of LAB and shows that the relatively small genomes of members of the Streptococcaceae family have been largely shaped by the nutritionally rich environments they inhabit.
On Metric Preheating
We consider the generation of super-horizon metric fluctuations during an
epoch of preheating in the presence of a scalar field \chi quadratically
coupled to the inflaton. We find that the requirement of efficient broad
resonance is concomitant with a severe damping of super-horizon \delta\chi
quantum fluctuations during inflation. Employing perturbation theory with
backreaction included as spatial averages to second order in the scalar fields
and in the metric, we argue that the usual inflationary prediction for metric
perturbations on scales relevant for structure formation is not strongly
modified.Comment: 5 latex pages, 1 postscript figure included, uses revtex.sty in two
column format and epsf.sty, some typos corrected and references added. Links
and further material at http://astro.uchicago.edu/home/web/sigl/r4.htm
Collaboration and contestation in further and higher education partnerships in England: a Bourdieusian field analysis
Internationally, ‘College for All’ policies are creating new forms of vocational higher education (HE), and shifting relationships between HE and further education (FE) institutions. In this paper, we consider the way in which this is being implemented in England, drawing on a detailed qualitative case study of a regional HE–FE partnership to widen participation. We focus on the complex mix of collaboration and contestation that arose within it, and how these affected socially differentiated groups of students following high- and low-status routes through its provision. We outline Bourdieu’s concept of ‘field’ as a framework for our analysis and interpretation, including its theoretical ambiguities regarding the definition and scale of fields. Through hermeneutic dialogue between data and theory, we tentatively suggest that such partnerships represent bridges between HE and FE. These bridges are strong between higher-status institutions, but highly contested between lower-status institutions competing closely for distinction. We conclude that the trajectories and outcomes for socially disadvantaged students require attention and collective action to address the inequalities they face, and that our theoretical approach may have wider international relevance beyond the English case
Metachronous colorectal cancer risk for mismatch repair gene mutation carriers – the advantage of more extensive surgery
Recommended from our members
Sixteen years of bathymetry and waves at San Diego beaches.
Sustained, quantitative observations of nearshore waves and sand levels are essential for testing beach evolution models, but comprehensive datasets are relatively rare. We document beach profiles and concurrent waves monitored at three southern California beaches during 2001-2016. The beaches include offshore reefs, lagoon mouths, hard substrates, and cobble and sandy (medium-grained) sediments. The data span two energetic El Niño winters and four beach nourishments. Quarterly surveys of 165 total cross-shore transects (all sites) at 100 m alongshore spacing were made from the backbeach to 8 m depth. Monthly surveys of the subaerial beach were obtained at alongshore-oriented transects. The resulting dataset consists of (1) raw sand elevation data, (2) gridded elevations, (3) interpolated elevation maps with error estimates, (4) beach widths, subaerial and total sand volumes, (5) locations of hard substrate and beach nourishments, (6) water levels from a NOAA tide gauge (7) wave conditions from a buoy-driven regional wave model, and (8) time periods and reaches with alongshore uniform bathymetry, suitable for testing 1-dimensional beach profile change models
The importance of learning processes in transitioning small-scale irrigation schemes
Many small-scale irrigation schemes are dysfunctional, and learning,
innovation and evaluation are required to facilitate sustainable
transitions. Using quantitative and qualitative data from five irrigation
schemes in sub-Saharan Africa, we analyze how learning and
change arose in response to: soil monitoring tools, which triggered
a deep learning cycle; and agricultural innovation platforms, which
helped develop a social learning system. Knowledge generation
and innovation were driven by the incentives of more profitable
farming. Learning and change spread to farmers without the tools,
and learning at different levels resulted in extension and governance
stakeholders facilitating profound institutional change
Periodic-Orbit Theory of Universality in Quantum Chaos
We argue semiclassically, on the basis of Gutzwiller's periodic-orbit theory,
that full classical chaos is paralleled by quantum energy spectra with
universal spectral statistics, in agreement with random-matrix theory. For
dynamics from all three Wigner-Dyson symmetry classes, we calculate the
small-time spectral form factor as power series in the time .
Each term of that series is provided by specific families of pairs of
periodic orbits. The contributing pairs are classified in terms of close
self-encounters in phase space. The frequency of occurrence of self-encounters
is calculated by invoking ergodicity. Combinatorial rules for building pairs
involve non-trivial properties of permutations. We show our series to be
equivalent to perturbative implementations of the non-linear sigma models for
the Wigner-Dyson ensembles of random matrices and for disordered systems; our
families of orbit pairs are one-to-one with Feynman diagrams known from the
sigma model.Comment: 31 pages, 17 figure
Locally recurrent chondrosarcoma of the pelvis and limbs can only be controlled by wide local excision
Aims The purpose of this study was to investigate the potential for achieving local and systemic control after local recurrence of a chondrosarcoma of bone. Patients and Methods A total of 126 patients with local recurrence (LR) of chondrosarcoma (CS) of the pelvis or a limb bone were identified from a prospectively maintained database, between 1990 and 2015 at the Royal Orthopaedic Hospital, Birmingham, United Kingdom. There were 44 female patients (35%) and 82 male patients (65%) with a mean age at the time of LR of 56 years (13 to 96). The 126 patients represented 24.3% of the total number of patients with a primary CS (519) who had been treated during this period. Clinical data collected at the time of primary tumour and LR included the site (appendicular, extremity, or pelvis); primary and LR tumour size (in centimetres); type of operation at the time of primary or LR (limb-salvage or amputation); surgical margin achieved at resection of the primary tumour and the LR; grade of the primary tumour and the LR; gender; age; and oncological outcomes, including local recurrence-free survival and disease-specific survival. A minimum two years' follow-up and complete histopathology records were available for all patients included in the study. Results For patients without metastases prior to or at the time of local recurrence, the disease-specific survival after local recurrence was 62.5% and 45.5% at one and five years, respectively, After univariable analysis, significant factors predicting disease-specific survival were grade (p <0.001) and surgical margin (p = 0.044). After multivariable analysis, grade, increasing age at the time of diagnosis of local recurrence, and a greater time interval from primary surgery to local recurrence were significant factors for disease-specific survival. A secondary local recurrence was seen in 26% of patients. Wide margins were a good predictor of local recurrence-free survival for subsequent recurrences after univariable analysis when compared with intralesional margins (p = 0.002) but marginal margins did not reach statistical significance when compared with intralesional margins (p = 0.084). Conclusion In cases of local recurrence of a chondrosarcoma of bone, we have shown that if the tumour is non-metastatic at re-staging, an increase in disease-specific survival and in local recurrence-free survival is achievable, but only by resection of the local recurrence with a wide margin.Peer reviewe
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