1,522 research outputs found

    Ground-based estimates of outer radiation belt energetic electron precipitation fluxes into the atmosphere

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    AARDDVARK data from a radio wave receiver in Sodankyla, Finland have been used to monitor transmissions across the auroral oval and just into the polar cap from the very low frequency communications transmitter, call sign NAA (24.0 kHz, 44 degrees N, 67 degrees W, L = 2.9), in Maine, USA, since 2004. The transmissions are influenced by outer radiation belt (L = 3-7) energetic electron precipitation. In this study, we have been able to show that the observed transmission amplitude variations can be used to determine routinely the flux of energetic electrons entering the upper atmosphere along the total path and between 30 and 90 km. Our analysis of the NAA observations shows that electron precipitation fluxes can vary by 3 orders of magnitude during geomagnetic storms. Typically when averaging over L = 3-7 we find that the >100 keV POES "trapped" fluxes peak at about 10(6) el. cm(-2) s(-1) sr(-1) during geomagnetic storms, with the DEMETER >100 keV drift loss cone showing peak fluxes of 105 el. cm(-2) s(-1) sr(-1), and both the POES >100 keV "loss" fluxes and the NAA ground-based >100 keV precipitation fluxes showing peaks of similar to 10(4) el. cm(-2) s(-1) sr(-1). During a geomagnetic storm in July 2005, there were systematic MLT variations in the fluxes observed: electron precipitation flux in the midnight sector (22-06 MLT) exceeded the fluxes from the morning side (0330-1130 MLT) and also from the afternoon sector (1130-1930 MLT). The analysis of NAA amplitude variability has the potential of providing a detailed, near real-time, picture of energetic electron precipitation fluxes from the outer radiation belts

    Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

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    SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: StrÄlin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino UnidoFil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: EmgÄrd, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; SueciaFil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Price, David A.. Cardiff University School of Medicine; Reino UnidoFil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; Sueci

    Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

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    SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19

    BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

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    BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project

    La XXe campagne de fouilles Ă  Mari (mars-mai 1972)

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    Parrot AndrĂ©. La XXe campagne de fouilles Ă  Mari (mars-mai 1972). In: Comptes rendus des sĂ©ances de l'AcadĂ©mie des Inscriptions et Belles-Lettres, 116ᔉ annĂ©e, N. 2, 1972. pp. 402-403

    Internationale Zeitschriftenschau fĂŒr Bibelwissenschaft und Grenzgebiete.

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    Parrot AndrĂ©. Internationale Zeitschriftenschau fĂŒr Bibelwissenschaft und Grenzgebiete.. In: Syria. Tome 32 fascicule 3-4, 1955. pp. 362-363

    E. Douglas van Buren. — The Rain-Goddess as represented in Early Mesopotamia. Extrait de Studia Biblica et Orientalia. — Vol. III : Oriens antiquus, pp. 343-355. Rome, 1959.

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    Parrot AndrĂ©. E. Douglas van Buren. — The Rain-Goddess as represented in Early Mesopotamia. Extrait de Studia Biblica et Orientalia. — Vol. III : Oriens antiquus, pp. 343-355. Rome, 1959.. In: Syria. Tome 37 fascicule 1-2, 1960. p. 193

    G. Posener, La légende égyptienne de la mer insatiable

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    Parrot André. G. Posener, La légende égyptienne de la mer insatiable. In: Syria. Tome 34 fascicule 1-2, 1957. pp. 206-207

    Philippe Reymond. — L'eau, sa vie et sa signification dans l'Ancien Testament.

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    Parrot AndrĂ©. Philippe Reymond. — L'eau, sa vie et sa signification dans l'Ancien Testament.. In: Syria. Tome 36 fascicule 1-2, 1959. pp. 135-136
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