Performance of the LHC magnet system

The LHC magnet system, essentially composed of superconducting magnets operating at 1.9 K, has been largely commissioned in 2007-08. Before the serious incident of 19th September 2008, the magnet system was commissioned up to 7 kA (4 TeV proton beam energy); six (out of eight) sectors were commissioned up to 5.5 TeV and one up to 6.6 TeV. For more than one week, both beams have been injected, circulated and captured in the RF bucket, thus assessing the optics at injection energy. The incident in sector 3-4, originated by a serious defect of a high-current joint between magnets with large collateral damage, has changed the plans: 53 magnets in the damaged zone have been substituted or repaired meanwhile a campaign of consolidation is under way to allow safe restart of the accelerator in fall 2009. All these points and other issues presented and discussed, with emphasis on the incident in sector 3-4

Dumb-bell galaxies in southern clusters: Catalog and preliminary statistical results

The dominant galaxy of a rich cluster is often an object whose formation and evolution is closely connected to the dynamics of the cluster itself. Hoessel (1980) and Schneider et al. (1983) estimate that 50 percent of the dominant galaxies are either of the dumb-bell type or have companions at projected distances less than 20 kpc, which is far in excess of the number expected from chance projection (see also Rood and Leir 1979). Presently there is no complete sample of these objects, with the exception of the listing of dumb-bell galaxies in BM type I and I-II clusters in the Abell statistical sample of Rood and Leir (1979). Recent dynamical studies of dumb-bell galaxies in clusters (Valentijn and Casertano, 1988) still suffer from inhomogeneity of the sample. The fact that it is a mixture of optically and radio selected objects may have introduced an unknown biases, for instance if the probability of radio emission is enhanced by the presence of close companions (Stocke, 1978, Heckman et al. 1985, Vettolani and Gregorini 1988) a bias could be present in their velocity distribution. However, this situation is bound to improve: a new sample of Abell clusters in the Southern Hemisphere has been constructed (Abell et al., 1988 hereafter ACO), which has several advantages over the original northern catalog. The plate material (IIIaJ plates) is of better quality and reaches fainter magnitudes. This makes it possible to classify the cluster types with a higher degree of accuracy, as well as to fainter magnitudes. The authors therefore decided to reconsider the whole problem constructing a new sample of dumb-bell galaxies homogeneously selected from the ACO survey. Details of the classification criteria are given

Identification of Some Errors in the Genome Assembly of Bovidae by FISH

From an economic point of view, Bovidae represent the most important family of the Ruminantia suborder. Thus, the mitochondrial and nuclear genomes of Bos taurus were among the first genomes to be sequenced after the sequencing of the human genomes. Over the millennia, the evolution of the genomes of the 3 main species belonging to the Bovidae family - B. taurus (BTA), Ovis aries (OAR), and Capra hircus (CHI) - has led to few chromosome rearrangements. Certainly, the availability and free access to the animal genomes significantly contributed to the improvement of animal genetics; however, some errors may exist due to the high automation in the genomic assembly construction process. In this work, some differences between the genomes of cattle, goat, and sheep highlighted by bioinformatics analysis have been verified by FISH, confirming that some errors persist even in the most recent genome assemblies. This type of approach has allowed us to detect a misassembly of a region belonging to BTA16 and to the homologues OAR12 and CHI16, a misassembly of a short tract in BTA22, OAR19, and CHI22, an incorrect mapping of a region of BTA21 and of CHI27 and OAR26, a discrepancy in the BTA26, OAR22, and CHI26 assemblies, a missed inversion in CHI1 compared to BTA1 and OAR1, and the exact assembly of a region of about 7 Mb in OAR10 and CHI12. Incorrect positioning of genomic tracts can cause unintended consequences in genetic analyses, especially when the data represent a starting point for the construction of genetic tools. In the new genomic assemblies published after the conclusion of our experiments, however, the accuracy in the construction of animal assemblies has been much improved, even if the new assemblies present more extended unmapped portions than the previous versions. The gap could be filled by comparative analyses between similar species or FISH

Structure of the magnetoionic medium around the FR Class I radio galaxy 3C 449

The goal of this work is to constrain the strength and structure of the magnetic field associated with the environment of the radio source 3C 449, using observations of Faraday rotation, which we model with a structure function technique and by comparison with numerical simulations. We assume that the magnetic field is a Gaussian, isotropic random variable and that it is embedded in the hot intra-group plasma surrounding the radio source. For this purpose, we present detailed rotation measure images for the polarized radio source 3C 449, previously observed with the Very Large Array at seven frequencies between 1.365 and 8.385 GHz. We quantify the statistics of the magnetic-field fluctuations by deriving rotation measure structure functions, which we fit using models derived from theoretical power spectra. We quantify the errors due to sampling by making multiple two-dimensional realizations of the best-fitting power spectrum.We also use depolarization measurements to estimate the minimum scale of the field variations. We then make three-dimensional models with a gas density distribution derived from X-ray observations and a random magnetic field with this power spectrum. Under these assumptions we find that both rotation measure and depolarization data are consistent with a broken power-law magnetic-field power spectrum, with a break at about 11 kpc and slopes of 2.98 and 2.07 at smaller and larger scales respectively. The maximum and minimum scales of the fluctuations are around 65 and 0.2 kpc, respectively. The average magnetic field strength at the cluster centre is 3.5 +/-1.2 micro-G, decreasing linearly with the gas density within about 16 kpc of the nucleus.Comment: 19 pages; 14 figures; accepted for publication on A&A. For a high quality version use ftp://ftp.eso.org/pub/general/guidetti

Intraplaque angiogenesis and therapeutic targeting of angiogenesis

During my PhD we have investigated different approaches to block intraplaque angiogenesis in atherosclerosis. Intraplaque angiogenesis is a physiological response to the increased oxygen demand in the plaque but also has adverse effects by facilitating intraplaque hemorrhage and influx of inflammatory mediators, resulting in plaque instability and consequent rupture. To study this phenomenon we used in vitro assays as well as the accelerated atherosclerosis vein graft model in ApoE3*Leiden mice, a unique model in which the formed plaque shows characteristics that highly resemble human atherosclerotic lesions, including intraplaque angiogenesis and hemorrhage and a high inflammatory cell content. We focused on different approaches to restore plaque stability via improving intraplaque oxygen levels as well as via blocking different growth factors signaling. Moreover we studied the effects of our treatments on the interaction between angiogenesis and inflammation both in vitro and in vivo.LUMC / Geneeskund

BeppoSAX observation of Hercules A and MRC 0625-536

We present BeppoSAX observations of the two FR I type radio galaxies Hercules A (3C 348) and MRC 0625-536 in the energy range $0.2 - 200$ keV. Data analysis shows that the X-ray flux from Hercules A is consistent with a diffuse thermal plasma emitting at $T \approx 4-5$ keV with a possible, but somewhat uncertain, contribution of a softer component at $T \approx 3$ keV. The non thermal emission from the active nucleus must be significantly smaller than the thermal one, and no indication of relevant core obscuration by a surrounding torus was detected. The flux from MRC 0625-536 originates form an extended region and has been fitted to a thermal law with $T \approx 5.7$ keV and with a column density consistent with the galactic absorption. A spatially resolved spectral analysis does not show a relevant variation of the temperature and the metallicity across the diffuse emission zone. A non thermal spectral component, related to the nuclear activity, may be present in the innermost region with some possible amount of local obscuration, contributing \lapp 10% to the total luminosity. Hard X-ray emission from MRC 0625-536 has been detected in the PDS (15 - 200 keV) that may be related either to its galactic core or to the intracluster region

The ATESP 5 GHz radio survey. II. Physical properties of the faint radio population

One of the most debated issues about sub-mJy radio sources, which are responsible for the steepening of the 1.4 GHz source counts, is the origin of their radio emission. Particularly interesting is the possibility of combining radio spectral index information with other observational properties to assess whether the sources are triggered by star formation or nuclear activity. The aim of this work is to study the optical and near infrared properties of a complete sample of 131 radio sources with S>0.4 mJy, observed at both 1.4 and 5 GHz as part of the ATESP radio survey. We use deep multi-colour (UBVRIJK) images, mostly taken in the framework of the ESO Deep Public Survey, to optically identify and derive photometric redshifts for the ATESP radio sources. Deep optical coverage and extensive colour information are available for 3/4 of the region covered by the radio sample. Typical depths of the images are U~25, B~26, V~25.4, R~25.5, I~24.3, 19.5<K_s<20.2, J<22.2. Optical/near infrared counterparts are found for ~78% (66/85) of the radio sources in the region covered by the deep multi-colour imaging, and for 56 of these reliable estimates of the redshift and type are derived. We find that many of the sources with flat radio spectra are characterised by high radio-to-optical ratios (R>1000), typical of classical powerful radio galaxies and quasars. Flat-spectrum sources with low R values are preferentially identified with early type galaxies, where the radio emission is most probably triggered by low-luminosity active galactic nuclei. Considering both early type galaxies and quasars as sources with an active nucleus, such sources largely dominate our sample (78%). Flat-spectrum sources associated with early type galaxies are quite compact (d<10-30 kpc), suggesting core-dominated radio emission.Comment: 15 pages, 13 figures, accepted for pubblication in A&

The ATESP Radio Survey II. The Source Catalogue

This paper is part of a series reporting the results of the Australia Telescope ESO Slice Project (ATESP) radio survey obtained at 1400 MHz with the Australia Telescope Compact Array (ATCA) over the region covered by the ESO Slice Project (ESP) galaxy redshift survey. The survey consists of 16 radio mosaics with ~8"x14" resolution and uniform sensitivity (1sigma noise level ~79 microJy) over the whole area of the ESP redshift survey (~26 sq. degrees at decl. -40 degr). Here we present the catalogue derived from the ATESP survey. We detected 2960 distinct radio sources down to a flux density limit of ~0.5 mJy (6sigma), 1402 being sub-mJy sources. We describe in detail the procedure followed for the source extraction and parameterization. The internal accuracy of the source parameters was tested with Monte Carlo simulations and possible systematic effects (e.g. bandwidth smearing) have been quantified.Comment: 14 pages, 14 Postscript figures, Accepted for publication in A&A Suppl. Corrected typos and added Journal Referenc

Anomalous Perception of Biological Motion in Autism: A Conceptual Review and Meta-Analysis

Despite its popularity, the construct of biological motion (BM) and its putative anomalies in autism spectrum disorder (ASD) are not completely clarified. In this article, we present a meta-analysis investigating the putative anomalies of BM perception in ASD. Through a systematic literature search, we found 30 studies that investigated BM perception in both ASD and typical developing peers by using point-light display stimuli. A general meta-analysis including all these studies showed a moderate deficit of individuals with ASD in BM processing, but also a high heterogeneity. This heterogeneity was explored in different additional meta-analyses where studies were grouped according to levels of complexity of the BM task employed (first-order, direct and instrumental), and according to the manipulation of low-level perceptual features (spatial vs. temporal) of the control stimuli. Results suggest that the most severe deficit in ASD is evident when perception of BM is serving a secondary purpose (e.g., inferring intentionality/action/emotion) and, interestingly, that temporal dynamics of stimuli are an important factor in determining BM processing anomalies in ASD. Our results question the traditional understanding of BM anomalies in ASD as a monolithic deficit and suggest a paradigm shift that deconstructs BM into distinct levels of processing and specific spatio-temporal subcomponents