Radiotherapy for Soft Tissue Sarcoma of the Proximal Lower Extremity

Soft-tissue sarcoma (STS) is a histopathologically diverse group of tumors accounting for approximately 10,000 new malignancies in the US each year. The proximal lower extremity is the most common site for STS, accounting for approximately one-third of all cases. Coordinated multimodality management in the form of surgery and radiation is often critical to local control, limb preservation, and functional outcome. Based on a review of currently available Medline literature and professional experience, this paper provides an overview of the treatment of STS of the lower extremity with a particular focus on the modern role of radiotherapy

Investigation of lower hybrid physics through power modulation experiments on Alcator C-Mod

Lower hybrid current drive (LHCD) is an attractive tool for off-axis current profile control in magnetically confined tokamak plasmas and burning plasmas (ITER), because of its high current drive efficiency. The LHCD system on Alcator C-Mod operates at 4.6 GHz, with ~ 1 MW of coupled power, and can produce a wide range of launched parallel refractive index (n[subscript ∣∣]) spectra. A 32 chord, perpendicularly viewing hard x-ray camera has been used to measure the spatial and energy distribution of fast electrons generated by lower hybrid (LH) waves. Square-wave modulation of LH power on a time scale much faster than the current relaxation time does not significantly alter the poloidal magnetic field inside the plasma and thus allows for realistic modeling and consistent plasma conditions for different n[subscript ∣∣] spectra. Inverted hard x-ray profiles show clear changes in LH-driven fast electron location with differing n[subscript ∣∣]. Boxcar binning of hard x-rays during LH power modulation allows for ~ 1 ms time resolution which is sufficient to resolve the build-up, steady-state, and slowing-down phases of fast electrons. Ray-tracing/Fokker-Planck modeling in combination with a synthetic hard x-raydiagnostic shows quantitative agreement with the x-ray data for high n[subscript ∣∣] cases. The time histories of hollow x-ray profiles have been used to measure off-axis fast electron transport in the outer half of the plasma, which is found to be small on a slowing down time scale.United States. Dept. of Energy (Award DE-FC02-99ER54512)United States. Dept. of Energy (Award DE-AC02-76CH03073

Speculations on Primordial Magnetic Helicity

We speculate that above or just below the electroweak phase transition magnetic fields are generated which have a net helicity (otherwise said, a Chern-Simons term) of order of magnitude $N_B + N_L$, where $N_{B,L}$ is the baryon or lepton number today. (To be more precise requires much more knowledge of B,L-generating mechanisms than we currently have.) Electromagnetic helicity generation is associated (indirectly) with the generation of electroweak Chern-Simons number through B+L anomalies. This helicity, which in the early universe is some 30 orders of magnitude greater than what would be expected from fluctuations alone in the absence of B+L violation, should be reasonably well-conserved through the evolution of the universe to around the times of matter dominance and decoupling, because the early universe is an excellent conductor. Possible consequences include early structure formation; macroscopic manifestations of CP violation in the cosmic magnetic field (measurable at least in principle, if not in practice); and an inverse-cascade dynamo mechanism in which magnetic fields and helicity are unstable to transfer to larger and larger spatial scales. We give a quasi-linear treatment of the general-relativistic MHD inverse cascade instability, finding substantial growth for helicity of the assumed magnitude out to scales $\sim l_M\epsilon^{-1}$, where $\epsilon$ is roughly the B+L to photon ratio and $l_M$ is the magnetic correlation length. We also elaborate further on an earlier proposal of the author for generation of magnetic fields above the EW phase transition.Comment: Latex, 23 page

Carbon on the Northwest European Shelf: Contemporary Budget and Future Influences

A carbon budget for the northwest European continental shelf seas (NWES) was synthesized using available estimates for coastal, pelagic and benthic carbon stocks and flows. Key uncertainties were identified and the effect of future impacts on the carbon budget were assessed. The water of the shelf seas contains between 210 and 230 Tmol of carbon and absorbs between 1.3 and 3.3 Tmol from the atmosphere annually. Off-shelf transport and burial in the sediments account for 60–100 and 0–40% of carbon outputs from the NWES, respectively. Both of these fluxes remain poorly constrained by observations and resolving their magnitudes and relative importance is a key research priority. Pelagic and benthic carbon stocks are dominated by inorganic carbon. Shelf sediments contain the largest stock of carbon, with between 520 and 1600 Tmol stored in the top 0.1 m of the sea bed. Coastal habitats such as salt marshes and mud flats contain large amounts of carbon per unit area but their total carbon stocks are small compared to pelagic and benthic stocks due to their smaller spatial extent. The large pelagic stock of carbon will continue to increase due to the rising concentration of atmospheric CO2, with associated pH decrease. Pelagic carbon stocks and flows are also likely to be significantly affected by increasing acidity and temperature, and circulation changes but the net impact is uncertain. Benthic carbon stocks will be affected by increasing temperature and acidity, and decreasing oxygen concentrations, although the net impact of these interrelated changes on carbon stocks is uncertain and a major knowledge gap. The impact of bottom trawling on benthic carbon stocks is unique amongst the impacts we consider in that it is widespread and also directly manageable, although its net effect on the carbon budget is uncertain. Coastal habitats are vulnerable to sea level rise and are strongly impacted by management decisions. Local, national and regional actions have the potential to protect or enhance carbon storage, but ultimately global governance, via controls on emissions, has the greatest potential to influence the long-term fate of carbon stocks in the northwestern European continental shelf

In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications

The human adenovirus phylogenetic tree is split across seven species (A–G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of pre-existing immunity detected across screened populations. However, many aspects of the basic virology of species D—such as their cellular tropism, receptor usage, and in vivo biodistribution profile—remain unknown. Here, we have characterized human adenovirus type 49 (HAdV-D49)—a relatively understudied species D member. We report that HAdV-D49 does not appear to use a single pathway to gain cell entry, but appears able to interact with various surface molecules for entry. As such, HAdV-D49 can transduce a broad range of cell types in vitro, with variable engagement of blood coagulation FX. Interestingly, when comparing in vivo biodistribution to adenovirus type 5, HAdV-D49 vectors show reduced liver targeting, whilst maintaining transduction of lung and spleen. Overall, this presents HAdV-D49 as a robust viral vector platform for ex vivo manipulation of human cells, and for in vivo applications where the therapeutic goal is to target the lung or gain access to immune cells in the spleen, whilst avoiding liver interactions, such as intravascular vaccine applications

Another exact inflationary solution

A new closed-form inflationary solution is given for a hyperbolic interaction potential. The method used to arrive at this solution is outlined as it appears possible to generate additional sets of equations which satisfy the model. In addition a new form of decaying cosmological constant is presented.Comment: 10 pages, 0 figure

Large carnivore science: non-experimental studies are useful, but experiments are better

1. Response to Bruskotter and colleagues We recently described the following six interrelated issues that justify questioning some of the discourse about the reliability of the literature on the ecological roles of large carnivores (Allen et al., in press): 1. The overall paucity of available data, 2. The reliability of carnivore population sampling techniques, 3. The general disregard for alternative hypotheses to top-down forcing, 4. The lack of applied science studies, 5. The frequent use of logical fallacies, 6. The generalisation of results from relatively pristine systems to those substantially altered by humans. We thank Bruskotter et al. (2017) for responding to our concerns and engaging with this important issue. We agree completely that nonexperimental studies can and do often have great value, and we recognize that in many (most) cases these types of studies may provide the only data that are available. We acknowledge the many challenges of working on large, cryptic, dangerous, and highly-mobile animals in the wild. However, the absence of more robust data and the reality of these challenges do not excuse weak inference or overstating conclusions – a practice apparent in many studies (and communication of those studies) adopting only observational or correlative methods to infer the roles of large carnivores (reviewed in Allen et al., in press)

Detection of the Power Spectrum of Cosmic Microwave Background Lensing by the Atacama Cosmology Telescope

We report the first detection of the gravitational lensing of the cosmic microwave background through a measurement of the four-point correlation function in the temperature maps made by the Atacama Cosmology Telescope. We verify our detection by calculating the levels of potential contaminants and performing a number of null tests. The resulting convergence power spectrum at 2-degree angular scales measures the amplitude of matter density fluctuations on comoving length scales of around 100 Mpc at redshifts around 0.5 to 3. The measured amplitude of the signal agrees with Lambda Cold Dark Matter cosmology predictions. Since the amplitude of the convergence power spectrum scales as the square of the amplitude of the density fluctuations, the 4-sigma detection of the lensing signal measures the amplitude of density fluctuations to 12%.Comment: 4 pages, 4 figures, replaced title and author list with version accepted by Physical Review Letters. Likelihood code can be downloaded from http://bccp.lbl.gov/~sudeep/ACTLensLike.htm

Evidence for dark energy from the cosmic microwave background alone using the Atacama Cosmology Telescope lensing measurements

For the first time, measurements of the cosmic microwave background radiation (CMB) alone favor cosmologies with $w=-1$ dark energy over models without dark energy at a 3.2-sigma level. We demonstrate this by combining the CMB lensing deflection power spectrum from the Atacama Cosmology Telescope with temperature and polarization power spectra from the Wilkinson Microwave Anisotropy Probe. The lensing data break the geometric degeneracy of different cosmological models with similar CMB temperature power spectra. Our CMB-only measurement of the dark energy density $\Omega_\Lambda$ confirms other measurements from supernovae, galaxy clusters and baryon acoustic oscillations, and demonstrates the power of CMB lensing as a new cosmological tool.Comment: 4 pages, 3 figures; replaced with version accepted by Physical Review Letters, added sentence on models with non-standard primordial power spectr

Clouds as Turbulent Density Fluctuations. Implications for pressure confinement and spectral line data interpretation

We examine the idea that diffuse and giant molecular clouds and their substructure form as density fluctuations induced by large scale interstellar turbulence. We do this by investigating the topology of various fields in realistic simulations of the ISM. We find that a) the velocity field is continuous across threshold-defined cloud boundaries; b) such cloud boundaries are rather arbitrary, with no correspondence to any actual physical boundary, such as a density discontinuity; c) abrupt velocity jumps are coincident with the density maxima; d) the volume and surface kinetic terms in the Eulerian Virial Theorem for a cloud ensemble are comparable in general; e) the magnetic field exhibits bends and reversals highly correlated with similar density features. These results suggest that clouds are formed by colliding gas streams. Within this framework, we argue that thermal pressure equilibrium is irrelevant for cloud confinement in a turbulent medium, since inertial motions can still distort or disrupt a cloud. Turbulent pressure confinement appears self-defeating, because turbulence contains large-scale motions which necessarily distort cloud boundaries. Density-weighted velocity histograms show similar FWHMs and similar multi-component structure to those of observational line profiles, though the histogram features do not correspond to isolated "clumps", but rather to extended regions throughout a cloud. We argue that the results presented here may be also applicable to small scales with larger densities (molecular clouds and cores) and suggest that quasi- hydrostatic configurations cannot be produced from turbulent fluctuations unless the thermodynamic behavior of the flow becomes nearly adiabatic at late stages of collapse. We expect this to occur only at protostellar densities.Comment: 20 pages, 11 PostScript figures, LaTex, ApJ submitted. Added reference to Chandrasekhar & Munch (1952) and corresponding discussio