1,169 research outputs found
The Australian Charter of Employment Rights: The missing dimensions
Just prior to the 2007 General Election, a group of labour lawyers and economists, broadly sympathetic to the Labor Party, produced a Charter of Employment Rights. This article examines the Charter's proposals and its underlying framework, and suggests significant aspects of work and labour have been omitted. It contends that the Charter would have been improved if it had not retained an artificially stretched definition of workers as employees, in which the only relationship worthy of inclusion in a Charter is that between the direct employer and employee. The framework and language of the Charter convey a paternalistic approach and an outdated focus on industrial labour, while ignoring aspects of the emerging global system of work linked to the concept of occupation
Conformal Hamiltonian Dynamics of General Relativity
The General Relativity formulated with the aid of the spin connection
coefficients is considered in the finite space geometry of similarity with the
Dirac scalar dilaton. We show that the redshift evolution of the General
Relativity describes the vacuum creation of the matter in the empty Universe at
the electroweak epoch and the dilaton vacuum energy plays a role of the dark
energy.Comment: 9 pages, 1 figure, submitted to PL
Gravitons and Lightcone Fluctuations
Gravitons in a squeezed vacuum state, the natural result of quantum creation
in the early universe or by black holes, will introduce metric fluctuations.
These metric fluctuations will introduce fluctuations of the lightcone. It is
shown that when the various two-point functions of a quantized field are
averaged over the metric fluctuations, the lightcone singularity disappears for
distinct points. The metric averaged functions remain singular in the limit of
coincident points. The metric averaged retarded Green's function for a massless
field becomes a Gaussian which is nonzero both inside and outside of the
classical lightcone. This implies some photons propagate faster than the
classical light speed, whereas others propagate slower. The possible effects of
metric fluctuations upon one-loop quantum processes are discussed and
illustrated by the calculation of the one-loop electron self-energy.Comment: 18pp, LATEX, TUTP-94-1
Superfluidity of flexible chains of polar molecules
We study properties of quantum chains in a gas of polar bosonic molecules
confined in a stack of N identical one- and two- dimensional optical lattice
layers, with molecular dipole moments aligned perpendicularly to the layers.
Quantum Monte Carlo simulations of a single chain (formed by a single molecule
on each layer) reveal its quantum roughening transition. The case of finite
in-layer density of molecules is studied within the framework of the J-current
model approximation, and it is found that N-independent molecular superfluid
phase can undergo a quantum phase transition to a rough chain superfluid. A
theorem is proven that no superfluidity of chains with length shorter than N is
possible. The scheme for detecting chain formation is proposed.Comment: Submitted to Proceedings of the QFS2010 satellite conference "Cold
Gases meet Many-Body Theory", Grenoble, August 7, 2010. This is the expanded
version of V.
Locating current sheets in the solar corona
Current sheets are essential for energy dissipation in the solar corona, in
particular by enabling magnetic reconnection. Unfortunately, sufficiently thin
current sheets cannot be resolved observationally and the theory of their
formation is an unresolved issue as well. We consider two predictors of coronal
current concentrations, both based on geometrical or even topological
properties of a force free coronal magnetic field. First, there are
separatrices related to magnetic nulls. Through separatrices the magnetic
connectivity changes discontinuously. Coronal magnetic nulls are, however, very
rare. At second, inspired by the concept of generalized magnetic reconnection
without nulls, quasi-separatrix layers (QSL) were suggested. Through QSL the
magnetic connectivity changes continuously, though strongly. The strength of
the connectivity change can be quantified by measuring the squashing of the
flux tubes which connect the magnetically conjugated photospheres.
We verify the QSL and separatrix concepts by comparing the sites of magnetic
nulls and enhanced squashing with the location of current concentrations in the
corona. Due to the known difficulties of their direct observation we simulated
the coronal current sheets by numerically calculating the response of the
corona to energy input from the photosphere heating a simultaneously observed
EUV Bright Point. We did not find coronal current sheets not at the
separatrices but at several QSL locations. The reason is that although the
geometrical properties of force free extrapolated magnetic fields can indeed,
hint at possible current concentrations, a necessary condition for current
sheet formation is the local energy input into the corona
Comprehensive molecular characterization of urachal adenocarcinoma reveals commonalities with colorectal cancer, including a hypermutable phenotype
Purpose Urachal adenocarcinoma is a rare type of primary bladder adenocarcinoma that comprises less than 1% of all bladder cancers. The low incidence of urachal adenocarcinomas does not allow for an evidence-based approach to therapy. Transcriptome profiling of urachal adenocarcinomas has not been previously reported.Wehypothesized that an in-depth molecular understanding of urachal adenocarcinoma would uncover rational therapeutic strategies. Patients and Methods We performed targeted exon sequencing and global transcriptome profiling of 12 urachal tumors to generate a comprehensive molecular portrait of urachal adenocarcinoma. A single patient with an MSH6 mutation was treated with the anti-programmed death-ligand 1 antibody, atezolizumab. Results Urachal adenocarcinoma closely resembles colorectal cancer at the level of RNA expression, which extends previous observations that urachal tumors harbor genomic alterations that are found in colorectal adenocarcinoma. A subset of tumors was found to have alterations in genes that are associated with microsatellite instability (MSH2 and MSH6) and hypermutation (POLE).Apatient with anMSH6mutation was treated withimmunecheckpoint blockade, which resulted in stable disease. Conclusion Because clinical trials are next to impossible for patients with rare tumors, precision oncology may be an important adjunct for treatment decisions. Our findings demonstrate that urachal adenocarcinomas molecularly resemble colorectal adenocarcinomas at the level ofRNA expression, are the first report, to our knowledge, of MSH2andMSH6mutations in this disease, and support the consideration of immune checkpoint blockade as a rational therapeutic treatment of this exceedingly rare tumor
Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study
Background: Most patients with juvenile myelomonocytic leukemia (JMML) are curable only with allogeneic hematopoietic cell transplantation (HCT). However, the current standard conditioning regimen, busulfan-cyclophosphamide-melphalan (Bu-Cy-Mel), may be associated with higher risks of morbidity and mortality. ASCT1221 was designed to test whether the potentially less-toxic myeloablative conditioning regimen containing busulfan-fludarabine (Bu-Flu) would be associated with equivalent outcomes. Procedure: Twenty-seven patients were enrolled on ASCT1221 from 2013 to 2015. Pre- and post-HCT (starting Day +30) mutant allele burden was measured in all and pre-HCT therapy was administered according to physician discretion. Results: Fifteen patients were randomized (six to Bu-Cy-Mel and nine to Bu-Flu) after meeting diagnostic criteria for JMML. Pre-HCT low-dose chemotherapy did not appear to reduce pre-HCT disease burden. Two patients, however, received aggressive chemotherapy pre-HCT and achieved low disease-burden state; both are long-term survivors. All four patients with detectable mutant allele burden at Day +30 post-HCT eventually progressed compared to two of nine patients with unmeasurable allele burden (P = 0.04). The 18-month event-free survival of the entire cohort was 47% (95% CI, 21–69%), and was 83% (95% CI, 27–97%) and 22% (95% CI, 03–51%) for Bu-Cy-Mel and Bu-Flu, respectively (P = 0.04). ASCT1221 was terminated early due to concerns that the Bu-Flu arm had inferior outcomes. Conclusions: The regimen of Bu-Flu is inadequate to provide disease control in patients with JMML who present to HCT with large burdens of disease. Advances in molecular testing may allow better characterization of biologic risk, pre-HCT responses to chemotherapy, and post-HCT management
Schwinger Pair Production via Instantons in Strong Electric Fields
In the space-dependent gauge, each mode of the Klein-Gordon equation in a
strong electric field takes the form of a time-independent Schr\"{o}dinger
equation with a potential barrier. We propose that the single- and
multi-instantons of quantum tunneling may be related with the single- and
multi-pair production of bosons and the relative probability for the no-pair
production is determined by the total tunneling probability via instantons. In
the case of a uniform electric field, the instanton interpretation recovers
exactly the well-known pair production rate for bosons and when the Pauli
blocking is taken into account, it gives the correct fermion production rate.
The instanton is used to calculate the pair production rate even in an
inhomogeneous electric field. Furthermore, the instanton interpretation
confirms the fact that bosons and fermions can not be produced by a static
magnetic field only.Comment: RevTex 7 Pages, No figure; Formulae for the production rate in very
strong fields and references added; the final version accepted in Phys. Rev.
Theory and Applications of Non-Relativistic and Relativistic Turbulent Reconnection
Realistic astrophysical environments are turbulent due to the extremely high
Reynolds numbers. Therefore, the theories of reconnection intended for
describing astrophysical reconnection should not ignore the effects of
turbulence on magnetic reconnection. Turbulence is known to change the nature
of many physical processes dramatically and in this review we claim that
magnetic reconnection is not an exception. We stress that not only
astrophysical turbulence is ubiquitous, but also magnetic reconnection itself
induces turbulence. Thus turbulence must be accounted for in any realistic
astrophysical reconnection setup. We argue that due to the similarities of MHD
turbulence in relativistic and non-relativistic cases the theory of magnetic
reconnection developed for the non-relativistic case can be extended to the
relativistic case and we provide numerical simulations that support this
conjecture. We also provide quantitative comparisons of the theoretical
predictions and results of numerical experiments, including the situations when
turbulent reconnection is self-driven, i.e. the turbulence in the system is
generated by the reconnection process itself. We show how turbulent
reconnection entails the violation of magnetic flux freezing, the conclusion
that has really far reaching consequences for many realistically turbulent
astrophysical environments. In addition, we consider observational testing of
turbulent reconnection as well as numerous implications of the theory. The
former includes the Sun and solar wind reconnection, while the latter include
the process of reconnection diffusion induced by turbulent reconnection, the
acceleration of energetic particles, bursts of turbulent reconnection related
to black hole sources as well as gamma ray bursts. Finally, we explain why
turbulent reconnection cannot be explained by turbulent resistivity or derived
through the mean field approach.Comment: 66 pages, 24 figures, a chapter of the book "Magnetic Reconnection -
Concepts and Applications", editors W. Gonzalez, E. N. Parke
Current status of turbulent dynamo theory: From large-scale to small-scale dynamos
Several recent advances in turbulent dynamo theory are reviewed. High
resolution simulations of small-scale and large-scale dynamo action in periodic
domains are compared with each other and contrasted with similar results at low
magnetic Prandtl numbers. It is argued that all the different cases show
similarities at intermediate length scales. On the other hand, in the presence
of helicity of the turbulence, power develops on large scales, which is not
present in non-helical small-scale turbulent dynamos. At small length scales,
differences occur in connection with the dissipation cutoff scales associated
with the respective value of the magnetic Prandtl number. These differences are
found to be independent of whether or not there is large-scale dynamo action.
However, large-scale dynamos in homogeneous systems are shown to suffer from
resistive slow-down even at intermediate length scales. The results from
simulations are connected to mean field theory and its applications. Recent
work on helicity fluxes to alleviate large-scale dynamo quenching, shear
dynamos, nonlocal effects and magnetic structures from strong density
stratification are highlighted. Several insights which arise from analytic
considerations of small-scale dynamos are discussed.Comment: 36 pages, 11 figures, Spa. Sci. Rev., submitted to the special issue
"Magnetism in the Universe" (ed. A. Balogh
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