3,881 research outputs found

    Family affairs: cohabitation, marriage and the law

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    The findings of a project on marriage and cohabitation, which included a module of questions in the British Social Attitudes Survey 2001.Nuffield Foundatio

    Social-science research and the general social surveys

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    'Social-science research has been transformed over the last generation by the advent and expansion of the general social surveys (GSS). The GSS model of research has created a infrastructure for the social sciences designed to address the interests and research agenda of scholars and their students; cover a wide range of topics; utilize reliable, valid, and generalizable measurement; and provide data both across nations and across time. This design in turn has generated widespread analysis and notably contributed to our understanding of social processes and societal change.' (author's abstract)

    A dual function for Pex3p in peroxisome formation and inheritance

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    Saccharomyces cerevisiae Pex3p has been shown to act at the ER during de novo peroxisome formation. However, its steady state is at the peroxisomal membrane, where its role is debated. Here we show that Pex3p has a dual function: one in peroxisome formation and one in peroxisome segregation. We show that the peroxisome retention factor Inp1p interacts physically with Pex3p in vitro and in vivo, and split-GFP analysis shows that the site of interaction is the peroxisomal membrane. Furthermore, we have generated PEX3 alleles that support peroxisome formation but fail to support recruitment of Inp1p to peroxisomes, and as a consequence are affected in peroxisome segregation. We conclude that Pex3p functions as an anchor for Inp1p at the peroxisomal membrane, and that this function is independent of its role at the ER in peroxisome biogenesis
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