Bringing wonder into medicine: a film-based curriculum

The proposed workshop presents a film-based curriculum in whole person care.This curriculum includes one 37-minute film (A Certain Kind of Light – screened in 18 film festivals around the world) and six smaller films that are each 5-10 minutes in length, and are accompanied by a journaling process (all of which explore whole person care in medicine). These are not the traditional “teaching” films, but films developed from a more artistic/creative standpoint, for the purposes of affecting attitudes, as much as teaching skills. The workshop will include the following: Introduction: Discussion of how the film-based curriculum impacts culture change as much as personal change of the healthcare practitioner. Content: If there is not enough time to show all 7 films, we would present at least four of them to help the participant understand both philosophy and content of the films, illustrating how whole person care concepts can be taught through an aesthetic avenue to more immediately affect thoughts, feelings, attitudes, and behaviors. In addition, we will discuss the journaling process, clinical rounds, and research that accompany the film curriculum. Finally, the panel will join together in discussing how this type of mechanism contributes to culture shift within an organization. Those presenting in this workshop are those who developed, teach and conduct research on this curriculum. This curriculum is newly developed (as of 2017) and is being used in a variety of healthcare disciplines within one healthcare educational and clinical entity and has been requested by several others

Farm Management Practices Used by Wheat Producers in the Western Great Plains: Estimating Their Productivity and Profitability

Changes in government farm programs and the introduction of new technology offer wheat producers in the western Great Plains a variety of management practices to alleviate biotic and agronomic constraints inherent in a wheat monoculture. Producers have adopted alternative tillage systems, crop diversification, and insect-resistant varieties in response to the hot, semiarid growing conditions and increased pest pressure. The objective of this study was to determine if those practices generated positive impacts on wheat yield and corresponding net returns. Panel data collected from a group of 141 producers over a four-year period (N = 564) were analyzed using econometric models. The most significant impacts were from crop diversification, which on average more than doubled returns from $29 to$69 per acre compared to a wheat monoculture. Pest-resistant varieties increased returns by 59%, from $32 to$51 per acre. The use of no-till reduced returns by an average of $13 per acre, but when combined with a modest level of crop diversity, returns approached breakeven. Stakeholders should aspire to increase the profitability of no-till to increase its adoption in this environmentally sensitive region

Dehydration entropy drives liquid-liquid phase separation by molecular crowding

Liquid-liquid phase separation occurs in cells and can be induced in artificial systems, but the mechanism of the effect of molecular crowders is unclear. Here dehydration entropy-driven phase separation of model charged polymers lacking any chemical complexity or hydrophobicity is shown to be enhanced by polyethylene glycol. Complex coacervation driven liquid-liquid phase separation (LLPS) of biopolymers has been attracting attention as a novel phase in living cells. Studies of LLPS in this context are typically of proteins harboring chemical and structural complexity, leaving unclear which properties are fundamental to complex coacervation versus protein-specific. This study focuses on the role of polyethylene glycol (PEG)-a widely used molecular crowder-in LLPS. Significantly, entropy-driven LLPS is recapitulated with charged polymers lacking hydrophobicity and sequence complexity, and its propensity dramatically enhanced by PEG. Experimental and field-theoretic simulation results are consistent with PEG driving LLPS by dehydration of polymers, and show that PEG exerts its effect without partitioning into the dense coacervate phase. It is then up to biology to impose additional variations of functional significance to the LLPS of biological systems.11Ysciescopu

Epidermal Growth Factor Receptor Mutations and the Clinical Outcome in Male Smokers with Squamous Cell Carcinoma of Lung

Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been reported to be related to certain clinical characteristics (i.e., female, non-smokers with adenocarcinoma) and gefitinib responsiveness. This exploratory analysis was performed to determine the incidence of EGFR mutations in male smokers with squamous cell carcinoma, who were treated with EGFR tyrosine kinase inhibitor, gefitinib. Sixty-nine Korean NSCLC patients were treated with gefitinib in a prospective study. For a subset of 20 male patients with squamous cell carcinoma and a history of smoking, pretreatment tumor tissue samples were obtained and analyzed for EGFR mutations (exons 18 to 21). EGFR mutations were found in 3 (15%) patients, including in-frame deletions within exon 19 (n=2) and L858R missence mutation in exon 21 (n=1). These 3 patients with EGFR mutations responded to gefitinib, whereas only one of remaining 17 patients with wild-type EGFR achieved clinical response. Trend toward longer progression-free (5.8 vs. 2.4 months; P=0.07) was noted in patients with EGFR mutations compared to those with wild-type EGFR. Although male smokers with squamous cell carcinoma have not been considered ideal candidates for gefitinib treatment, significant incidence of EGFR mutations was observed. The molecular markers should be considered to predict clinical benefits from gefitinib

Composition of dissolved organic matter within a lacustrine environment

Freshwater dissolved organic matter (DOM) is a complex mixture of chemical components that are central to many environmental processes, including carbon and nitrogen cycling. However, questions remain as to its chemical characteristics, sources and transformation mechanisms. Here, we employ 1- and 2-D nuclear magnetic resonance (NMR) spectroscopy to investigate the structural components of lacustrine DOM from Ireland, and how it varies within a lake system, as well as to assess potential sources. Major components found, such as carboxyl-rich alicyclic molecules (CRAM) are consistent with those recently identified in marine and freshwater DOM. Lignin-type markers and protein/peptides were identified and vary spatially. Phenylalanine was detected in lake areas influenced by agriculture, whereas it is not detectable where zebra mussels are prominent. The presence of peptidoglycan, lipoproteins, large polymeric carbo- hydrates and proteinaceous material supports the substantial contribution of material derived from microorganisms. Evidence is provided that peptidoglycan and silicate species may in part originate from soil microbes

Comparing Dawn, Hubble Space Telescope, and Ground-Based Interpretations of (4) Vesta

Observations of asteroid 4 Vesta by NASA's Dawn spacecraft are interesting because its surface has the largest range of albedo, color and composition of any other asteroid visited by spacecraft to date. These hemispherical and rotational variations in surface brightness and composition have been attributed to impact processes since Vesta's formation. Prior to Dawn's arrival at Vesta, its surface properties were the focus of intense telescopic investigations for nearly a hundred years. Ground-based photometric and spectroscopic observations first revealed these variations followed later by those using Hubble Space Telescope. Here we compare interpretations of Vesta's rotation period, pole, albedo, topographic, color, and compositional properties from ground-based telescopes and HST with those from Dawn. Rotational spectral variations observed from ground-based studies are also consistent with those observed by Dawn. While the interpretation of some of these features was tenuous from past data, the interpretations were reasonable given the limitations set by spatial resolution and our knowledge of Vesta and HED meteorites at that time. Our analysis shows that ground-based and HST observations are critical for our understanding of small bodies and provide valuable support for ongoing and future spacecraft missions.Comment: Pages: 51, Figures: 9, Tables: