Electrical conductivity images of Quaternary faults and Tertiary detachments in the California Basin and Range

Comparison of an electrical resistivity section derived from magnetotelluric (MT) data to a geologic section extending eastward from the Sierra Nevada near latitude 36°20′N shows that the crust is dominated by steeply dipping conductive features that correlate with active strike-slip faults. While there is a subhorizontal conductor at a depth ∼20 km beneath some of the profile, it is broken by vertical structures associated with the active strike-slip faults. The continuous subhorizontal anomalies in the lower crust typically observed in extensional regions are therefore absent in the resistivity section. The present-day strike-slip tectonic regime as indicated by geodetic data in this part of the Basin and Range is not producing features that could be inferred to indicate subhorizontal shear zones resulting from lateral crustal flow during extension. Because the Miocene tectonic regime resulted in the formation of metamorphic core complexes and thus was accompanied by such flow, the present regime appears to represent a fundamental transition in the mode of crustal deformation in the region. A serendipitous result of our study was the identification on resistivity sections of carbonate aquifers in the upper crust. Comparison of resistivities from the MT section to measured fluid resistivities from springs and boreholes suggests that the aquifers must be heterogeneous, with more saline brines occupying the deepest portions of the carbonates

Point-of-care versus central testing of hemoglobin during large volume blood transfusion.

BACKGROUND: Point-of-care (POC) hemoglobin testing has the potential to revolutionize massive transfusion strategies. No prior studies have compared POC and central laboratory testing of hemoglobin in patients undergoing massive transfusions. METHODS: We retrospectively compared the results of our point-of-care hemoglobin test (EPOC®) to our core laboratory complete blood count (CBC) hemoglobin test (Sysmex XE-5000™) in patients undergoing massive transfusion protocols (MTP) for hemorrhage. One hundred seventy paired samples from 90 patients for whom MTP was activated were collected at a single, tertiary care hospital between 10/2011 and 10/2017. Patients had both an EPOC® and CBC hemoglobin performed within 30 min of each other during the MTP. We assessed the accuracy of EPOC® hemoglobin testing using two variables: interchangeability and clinically significant differences from the CBC. The Clinical Laboratory Improvement Amendments (CLIA) proficiency testing criteria defined interchangeability for measurements. Clinically significant differences between the tests were defined by an expert panel. We examined whether these relationships changed as a function of the hemoglobin measured by the EPOC® and specific patient characteristics. RESULTS: Fifty one percent (86 of 170) of paired samples\u27 hemoglobin results had an absolute difference of ≤7 and 73% (124 of 170) fell within ±1 g/dL of each other. The mean difference between EPOC® and CBC hemoglobin had a bias of - 0.268 g/dL (p = 0.002). When the EPOC® hemoglobin was \u3c 7 g/dL, 30% of the hemoglobin values were within ±7, and 57% were within ±1 g/dL. When the measured EPOC® hemoglobin was ≥7 g/dL, 55% of the EPOC® and CBC hemoglobin values were within ±7, and 76% were within ±1 g/dL. EPOC® and CBC hemoglobin values that were within ±1 g/dL varied by patient population: 77% for cardiac surgery, 58% for general surgery, and 72% for non-surgical patients. CONCLUSIONS: The EPOC® device had minor negative bias, was not interchangeable with the CBC hemoglobin, and was less reliable when the EPOC® value was \u3c 7 g/dL. Clinicians must consider speed versus accuracy, and should check a CBC within 30 min as confirmation when the EPOC® hemoglobin is \u3c 7 g/dL until further prospective trials are performed in this population

Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease

AbstractThe incidence of end stage kidney disease is rising annually and it is now a global public health problem. Current treatment options are dialysis or renal transplantation, which apart from their significant drawbacks in terms of increased morbidity and mortality, are placing an increasing economic burden on society. Cell-based Regenerative Medicine Therapies (RMTs) have shown great promise in rodent models of kidney disease, but clinical translation is hampered due to the lack of adequate safety and efficacy data. Furthermore, the mechanisms whereby the cell-based RMTs ameliorate injury are ill-defined. For instance, it is not always clear if the cells directly replace damaged renal tissue, or whether paracrine effects are more important. Knowledge of the mechanisms responsible for the beneficial effects of cell therapies is crucial because it could lead to the development of safer and more effective RMTs in the future. To address these questions, novel in vivo imaging strategies are needed to monitor the biodistribution of cell-based RMTs and evaluate their beneficial effects on host tissues and organs, as well as any potential adverse effects. In this review we will discuss how state-of-the-art imaging modalities, including bioluminescence, magnetic resonance, nuclear imaging, ultrasound and an emerging imaging technology called multispectral optoacoustic tomography, can be used in combination with various imaging probes to track the fate and biodistribution of cell-based RMTs in rodent models of kidney disease, and evaluate their effect on renal function

Emergence of Superlattice Dirac Points in Graphene on Hexagonal Boron Nitride

The Schr\"odinger equation dictates that the propagation of nearly free electrons through a weak periodic potential results in the opening of band gaps near points of the reciprocal lattice known as Brillouin zone boundaries. However, in the case of massless Dirac fermions, it has been predicted that the chirality of the charge carriers prevents the opening of a band gap and instead new Dirac points appear in the electronic structure of the material. Graphene on hexagonal boron nitride (hBN) exhibits a rotation dependent Moir\'e pattern. In this letter, we show experimentally and theoretically that this Moir\'e pattern acts as a weak periodic potential and thereby leads to the emergence of a new set of Dirac points at an energy determined by its wavelength. The new massless Dirac fermions generated at these superlattice Dirac points are characterized by a significantly reduced Fermi velocity. The local density of states near these Dirac cones exhibits hexagonal modulations indicating an anisotropic Fermi velocity.Comment: 16 pages, 6 figure

Early (and Later) LHC Search Strategies for Broad Dimuon Resonances

Resonance searches generally focus on narrow states that would produce a sharp peak rising over background. Early LHC running will, however, be sensitive primarily to broad resonances. In this paper we demonstrate that statistical methods should suffice to find broad resonances and distinguish them from both background and contact interactions over a large range of previously unexplored parameter space. We furthermore introduce an angular measure we call ellipticity, which measures how forward (or backward) the muon is in eta, and allows for discrimination between models with different parity violation early in the LHC running. We contrast this with existing angular observables and demonstrate that ellipticity is superior for discrimination based on parity violation, while others are better at spin determination.Comment: 31 pages, 19 figures. References added, minor modifications made to section

CPPN2GAN: Combining Compositional Pattern Producing Networks and GANs for Large-Scale Pattern Generation

Generative Adversarial Networks (GANs) are proving to be a powerful indirect genotype-to-phenotype mapping for evolutionary search, but they have limitations. In particular, GAN output does not scale to arbitrary dimensions, and there is no obvious way of combining multiple GAN outputs into a cohesive whole, which would be useful in many areas, such as the generation of video game levels. Game levels often consist of several segments, sometimes repeated directly or with variation, organized into an engaging pattern. Such patterns can be produced with Compositional Pattern Producing Networks (CPPNs). Specifically, a CPPN can define latent vector GAN inputs as a function of geometry, which provides a way to organize level segments output by a GAN into a complete level. This new CPPN2GAN approach is validated in both Super Mario Bros. and The Legend of Zelda. Specifically, divergent search via MAP-Elites demonstrates that CPPN2GAN can better cover the space of possible levels. The layouts of the resulting levels are also more cohesive and aesthetically consistent.Comment: GECCO 2020. arXiv admin note: text overlap with arXiv:2004.0015

Student perceptions of iPads as mobile learning devices for fieldwork

This paper reports findings from six field courses about student’s perceptions of iPads as mobile learning devices for fieldwork. Data were collected through surveys and focus groups. The key findings suggest that the multi-tool nature of the iPads and their portability were the main strengths. Students had some concerns over the safety of the iPads in adverse weather and rugged environments, though most of these concerns were eliminated after using the devices with protective cases. Reduced connectivity was found to be one of the main challenges for mobile learning. Finally, students and practitioners views of why they used the mobile devices for fieldwork did not align

Two nonmagnetic impurities in the DSC and DDW state of the cuprate superconductors as a probe for the pseudogap

The quantum interference between two nonmagnetic impurities is studied numerically in both the d-wave superconducting (DSC) and the d-density wave (DDW) state. In all calculations we include the tunnelling through excited states from the CuO$_2$ planes to the BiO layer probed by the STM tip. Compared to the single impurity case, a systematic study of the modulations in the two-impurity local density of states can distinguish between the DSC or DDW states. This is important if the origin of the pseudogap phase is caused by preformed pairs or DDW order. Furthermore, in the DSC state the study of the LDOS around two nonmagnetic impurities provide further tests for the potential scattering model versus more strongly correlated models.Comment: 6 pages, 6 figure

The Axial-Vector Current in Nuclear Many-Body Physics

Weak-interaction currents are studied in a recently proposed effective field theory of the nuclear many-body problem. The Lorentz-invariant effective field theory contains nucleons, pions, isoscalar scalar ($\sigma$) and vector ($\omega$) fields, and isovector vector ($\rho$) fields. The theory exhibits a nonlinear realization of $SU(2)_L \times SU(2)_R$ chiral symmetry and has three desirable features: it uses the same degrees of freedom to describe the axial-vector current and the strong-interaction dynamics, it satisfies the symmetries of the underlying theory of quantum chromodynamics, and its parameters can be calibrated using strong-interaction phenomena, like hadron scattering or the empirical properties of finite nuclei. Moreover, it has recently been verified that for normal nuclear systems, it is possible to systematically expand the effective lagrangian in powers of the meson fields (and their derivatives) and to reliably truncate the expansion after the first few orders. Here it is shown that the expressions for the axial-vector current, evaluated through the first few orders in the field expansion, satisfy both PCAC and the Goldberger--Treiman relation, and it is verified that the corresponding vector and axial-vector charges satisfy the familiar chiral charge algebra. Explicit results are derived for the Lorentz-covariant, axial-vector, two-nucleon amplitudes, from which axial-vector meson-exchange currents can be deduced.Comment: 32 pages, REVTeX 4.0 with 12pt.rtx, aps.rtx, revsymb.sty, revtex4.cls, plus 14 figures; two sentences added in Summary; two references adde