105 research outputs found

    Π”ΠΈΠ½Π°ΠΌΠΈΠΊΠ° внСшнСй Ρ‚ΠΎΡ€Π³ΠΎΠ²Π»ΠΈ ΠšΠΈΡ‚Π°Ρ ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ страны Π² ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ экономикС

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    The article presents the analysis of dynamics of foreign trade of the Peoples Republic of China, shifts in geographical and commodity structure of export and import since 1995 until present. Their influence on change of country's position in world economy and international trade is revealed. Analyzing the statistical data, authors come to a conclusion that modernization and transparency of economy, expansion of foreign economic relations, considering direct correlation of rates of gross domestic product (GDP) and rates of development of foreign trade of the country, have led to essential strengthening of China's position in world production of manufacturing industry, in world economy, and international trade.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСн Π°Π½Π°Π»ΠΈΠ· Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ внСшнСй Ρ‚ΠΎΡ€Π³ΠΎΠ²Π»ΠΈ КНР, сдвигов Π² гСографичСской ΠΈ Ρ‚ΠΎΠ²Π°Ρ€Π½ΠΎΠΉ структурС экспорта ΠΈ ΠΈΠΌΠΏΠΎΡ€Ρ‚Π° с 1995 Π³. ΠΏΠΎ настоящСС врСмя. ВыявляСтся ΠΈΡ… влияниС Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ страны Π² ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ экономикС ΠΈ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ Ρ‚ΠΎΡ€Π³ΠΎΠ²Π»Π΅. Анализируя статистичСскиС Π΄Π°Π½Π½Ρ‹Π΅, Π°Π²Ρ‚ΠΎΡ€Ρ‹ приходят ΠΊ Π²Ρ‹Π²ΠΎΠ΄Ρƒ, Ρ‡Ρ‚ΠΎ модСрнизация ΠΈ ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚ΠΎΡΡ‚ΡŒ экономики, Ρ€Π°ΡΡˆΠΈΡ€Π΅Π½ΠΈΠ΅ Π²Π½Π΅ΡˆΠ½Π΅ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡ‡Π΅ΡΠΊΠΈΡ… связСй, учитывая ΠΏΡ€ΡΠΌΡƒΡŽ ΠΊΠΎΡ€Ρ€Π΅Π»ΡΡ†ΠΈΡŽ Ρ‚Π΅ΠΌΠΏΠΎΠ² Π’Π’ΠŸ ΠΈ Ρ‚Π΅ΠΌΠΏΠΎΠ² развития внСшнСй Ρ‚ΠΎΡ€Π³ΠΎΠ²Π»ΠΈ страны, ΠΏΡ€ΠΈΠ²Π΅Π»ΠΈ ΠΊ сущСствСнному ΡƒΠΊΡ€Π΅ΠΏΠ»Π΅Π½ΠΈΡŽ ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ ΠšΠΈΡ‚Π°Ρ Π² ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΌ производствС ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ ΠΎΠ±Ρ€Π°Π±Π°Ρ‚Ρ‹Π²Π°ΡŽΡ‰Π΅ΠΉ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΡΡ‚ΠΈ, Π² ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ экономикС ΠΈ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ Ρ‚ΠΎΡ€Π³ΠΎΠ²Π»Π΅

    Π˜ΡΡ…ΠΎΠ΄Ρ‹ Π½ΠΎΠ²ΠΎΠΉ коронавирусной ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ COVID-19 Ρƒ 68 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌΠΈ заболСваниями ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ°

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    Background. COVID-19 is an infectious respiratory syndrome with a wide range of manifestations and outcomes. Patients with inflammatory bowel disease (IBD) generally have a higher risk of infection, especially if they receive immunosuppressive therapy. Aim to describe the manifestations of COVID-19 in patients with IBD and to determine the risk factors for severe COVID-19. Methods. The analysis included 68 patients with an established diagnosis of Crohns disease (CD) or ulcerative colitis and a confirmed new coronavirus infection. The diagnosis of coronavirus infection was established when SARS-CoV-2 was detected by PCR using nasopharyngeal smears, and computer tomography (CT) of the chest revealed inflammatory changes characteristic of coronavirus lung damage or high IgG and IgM titers based on the results of immunological blood analysis. Results. 68 patients with IBD and COVID-19 were observed in the Department of IBD, including 27 (39.7%) patients with CD, 41 (60.3%) patients with UC. Among patients diagnosed with pneumonia, 100 % of patients received therapy with thiopurines and infliximab. 8 (11.8%) patients were diagnosed with COVID-19 during hospitalization for a severe IBD attack. There was no statistically significant difference between UC and CD patients in terms of disease activity (p = 0.13) during the period of coronavirus infection. In 37 patients (26 UC, 11 BC) with pneumonia (100%), there was an exacerbation of IBD. Statistical significance was found between the development of more severe lung damage (CT 34) and IBD activity at the time of diagnosis of COVID-19 (p 0.001), the presence of comorbidities (p 0.001) and taking GCS (p 0.001) at the time of detection of COVID-19. However, the use of biological and immunosuppressive therapy was not associated with a higher risk of severe lung damage and the need for a ventilator. It was shown that the age of patients over 65 years was statistically correlated with the need for a ventilator (p = 0.02). Conclusion. The exacerbation of the disease, especially in elderly patients with comorbidities, the use of glucocorticosteroids was associated with negative consequences of COVID-19, while biological and immunosuppressant drugs used for the treatment of IBD did not have such a negative effect.ОбоснованиС. COVID-19 это ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ рСспираторный синдром с ΡˆΠΈΡ€ΠΎΠΊΠΈΠΌ спСктром проявлСний ΠΈ исходов. ΠŸΠ°Ρ†ΠΈΠ΅Π½Ρ‚Ρ‹ с Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌΠΈ заболСваниями ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ° (Π’Π—Πš) ΠΈΠΌΠ΅ΡŽΡ‚ больший риск инфицирования SARS-CoV-2, Π² особСнности Ссли ΠΎΠ½ΠΈ ΠΏΠΎΠ»ΡƒΡ‡Π°ΡŽΡ‚ ΠΈΠΌΠΌΡƒΠ½ΠΎΡΡƒΠΏΡ€Π΅ΡΡΠΈΠ²Π½ΡƒΡŽ Ρ‚Π΅Ρ€Π°ΠΏΠΈΡŽ. ЦСль исслСдования ΠΎΠΏΠΈΡΠ°Ρ‚ΡŒ проявлСния COVID-19 Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π’Π—Πš ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΡ‚ΡŒ Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹ риска тяТСлого тСчСния COVID-19. ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ Π°Π½Π°Π»ΠΈΠ· Π±Ρ‹Π»ΠΈ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½Ρ‹ 68 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² c установлСнным Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠšΡ€ΠΎΠ½Π° (Π‘Πš) ΠΈΠ»ΠΈ язвСнного ΠΊΠΎΠ»ΠΈΡ‚Π° (ЯК) ΠΈ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π½ΠΎΠΉ Π½ΠΎΠ²ΠΎΠΉ коронавирусной ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠ΅ΠΉ. Π”ΠΈΠ°Π³Π½ΠΎΠ· коронавирусной ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ устанавливался ΠΏΡ€ΠΈ выявлСнии SARS-CoV-2 ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ПЦР Π½Π°Π·ΠΎΡ„Π°Ρ€ΠΈΠ½Π³Π΅Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ°Π·ΠΊΠΎΠ², выявлСнии ΠΏΡ€ΠΈ ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠΉ Ρ‚ΠΎΠΌΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ (КВ) ΠΎΡ€Π³Π°Π½ΠΎΠ² Π³Ρ€ΡƒΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ, Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹Ρ… для коронавирусного пораТСния Π»Π΅Π³ΠΊΠΈΡ…, ΠΈΠ»ΠΈ высокого Ρ‚ΠΈΡ‚Ρ€Π° IgG ΠΈ IgM ΠΏΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ иммунологичСского Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΡ€ΠΎΠ²ΠΈ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. 68 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π’Π—Πš ΠΈ COVID-19 наблюдались Π² ΠΎΡ‚Π΄Π΅Π»Π΅Π½ΠΈΠΈ лСчСния Московского клиничСского Π½Π°ΡƒΡ‡Π½ΠΎ-практичСского Ρ†Π΅Π½Ρ‚Ρ€Π° ΠΈΠΌΠ΅Π½ΠΈ А.Π‘. Π›ΠΎΠ³ΠΈΠ½ΠΎΠ²Π°, ΠΈΠ· Π½ΠΈΡ… 27 (39,7%) ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π‘Πš, 41 (60,3%) ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ с ЯК. НС Π±Ρ‹Π»ΠΎ выявлСно статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎΠ³ΠΎ различия ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°ΠΌΠΈ ЯК ΠΈ Π‘Πš Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ активности заболСвания (p = 0,13) Π² ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ коронавирусной ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ. Π£ 37 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² (26 с ЯК, 11 с Π‘Πš) с ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ (100%) имСлось обострСниС Π’Π—Πš. Π£ 8 (11,8%) ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π±Ρ‹Π» диагностирован COVID-19 Π²ΠΎ врСмя госпитализации ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρƒ тяТСлой Π°Ρ‚Π°ΠΊΠΈ Π’Π—Πš. Π‘Ρ‹Π»Π° выявлСна статистичСская Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ Π±ΠΎΠ»Π΅Π΅ тяТСлого пораТСния Π»Π΅Π³ΠΊΠΈΡ… (КВ 34) ΠΈ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ Π’Π—Πš Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ‚ диагностирования COVID-19 (p 0,001), Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ΠΌ ΡΠΎΠΏΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ (p 0,001) ΠΈ ΠΏΡ€ΠΈΠ΅ΠΌΠΎΠΌ Π“ΠšΠ‘ (p 0,001) Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ‚ выявлСния COVID-19. ΠŸΡ€ΠΈ этом ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ биологичСской ΠΈ иммуносупрСссивной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Π½Π΅ Π±Ρ‹Π»ΠΎ связано с Π±ΠΎΠ»Π΅Π΅ высоким риском тяТСлого пораТСния Π»Π΅Π³ΠΊΠΈΡ… ΠΈ ΠΏΠΎΡ‚Ρ€Π΅Π±Π½ΠΎΡΡ‚ΡŒΡŽ Π² Π˜Π’Π›. Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ возраст ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π±ΠΎΠ»Π΅Π΅ 65 Π»Π΅Ρ‚ статистичСски ΠΊΠΎΡ€Ρ€Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π» с ΠΏΠΎΡ‚Ρ€Π΅Π±Π½ΠΎΡΡ‚ΡŒΡŽ Π² Π˜Π’Π› (p = 0,02). Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ΠžΠ±ΠΎΡΡ‚Ρ€Π΅Π½ΠΈΠ΅ заболСвания, Π² особСнности Ρƒ ΠΏΠΎΠΆΠΈΠ»Ρ‹Ρ… ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΡΠΎΠΏΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π΅ΠΉ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ, ΠΈ ΠΏΡ€ΠΈΠ΅ΠΌ Π³Π»ΡŽΠΊΠΎΠΊΠΎΡ€Ρ‚ΠΈΠΊΠΎΡΡ‚Π΅Ρ€ΠΎΠΈΠ΄ΠΎΠ² ΠΈΠΌΠ΅Π»ΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡ‚ΡŒ с Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ послСдствиями COVID-19, Π² Ρ‚ΠΎ врСмя ΠΊΠ°ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ‹ биологичСской ΠΈ иммуносупрСссорной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ, примСняСмыС для лСчСния Π’Π—Πš, Π½Π΅ ΠΎΠΊΠ°Π·Ρ‹Π²Π°Π»ΠΈ Ρ‚Π°ΠΊΠΎΠ³ΠΎ Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ влияния

    Registration of atmospheric neutrinos with the Baikal neutrino telescope

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    We present first neutrino induced events observed with a deep underwater neutrino telescope. Data from 70 days effective life time of the BAIKAL prototype telescope NT-96 have been analyzed with two different methods. With the standard track reconstruction method, 9 clear upward muon candidates have been identified, in good agreement with 8.7 events expected from Monte Carlo calculations for atmospheric neutrinos. The second analysis is tailored to muons coming from close to the opposite zenith. It yields 4 events, compared to 3.5 from Monte Carlo expectations. From this we derive a 90 % upper flux limit of 1.1 * 10^-13 cm^-2 sec^-1 for muons in excess of those expected from atmospheric neutrinos with zenith angle > 150 degrees and energy > 10GeV.Comment: 20 pages, 11 figure

    The Baikal Deep Underwater Neutrino Experiment: Results, Status, Future

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    We review the present status of the Baikal Underwater Neutrino Experiment and present results obtained with the various stages of the stepwise increasing detector: NT-36 (1993-95), NT-72 (1995-96) and NT-96 (1996-97). Results cover atmospheric muons, first clear neutrino events, search for neutrinos from WIMP annihilation in the center of the Earth, search for magnetic monopoles, and -- far from astroparticle physics -- limnology.Comment: Talk given at the Int. School on Nuclear Physics, Erice, Sept.199

    First record of Rhabdoceras suessi (Ammonoidea, Late Triassic) from the Transylvanian Triassic Series of the Eastern Carpathians (Romania) and a review of its biochronology, paleobiogeography and paleoecology

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    Abstract The occurrence of the heteromorphic ammonoid Rhabdoceras suessi Hauer, 1860, is recorded for the first time in the Upper Triassic limestone of the Timon-Ciungi olistolith in the Rarău Syncline, Eastern Carpathians. A single specimen of Rhabdoceras suessi co-occurs with Monotis (Monotis) salinaria that constrains its occurrence here to the Upper Norian (Sevatian 1). It is the only known heteromorphic ammonoid in the Upper Triassic of the Romanian Carpathians. Rhabdoceras suessi is a cosmopolitan species widely recorded in low and mid-paleolatitude faunas. It ranges from the Late Norian to the Rhaetian and is suitable for high-resolution worldwide correlations only when it co-occurs with shorter-ranging choristoceratids, monotid bivalves, or the hydrozoan Heterastridium. Formerly considered as the index fossil for the Upper Norian (Sevatian) Suessi Zone, by the latest 1970s this species lost its key biochronologic status among Late Triassic ammonoids, and it generated a controversy in the 1980s concerning the status of the Rhaetian stage. New stratigraphic data from North America and Europe in the subsequent decades resulted in a revised ammonoid biostratigraphy for the uppermost Triassic, the Rhaetian being reinstalled as the topmost stage in the current standard timescale of the Triassic. The geographic distribution of Rhabdoceras is compiled from published worldwide records, and its paleobiogeography and paleoecology are discussed

    First record of Rhabdoceras suessi

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    ЭпидСмиология Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ Π² ΠΌΠΈΡ€Π΅

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    The review presents the data on the prevalence of celiac disease in various world regions. The numbers of patients with celiac disease continues to rise every year. According to some authors, this is to be related not only to improvement in diagnosis, but to other extrinsic factors, as well, that require additional studies. In the 1980s the prevalence of this disease was 1.05%, and by the beginning of 2000s, it amounted to 1.99%. In particular, from 1993 to 2002 in Britain its incidence increased from 6 to 13.3 per 100,000. Both raised awareness of doctors and conduction of epidemiological studies play aΒ decisive role in the improvement of the diagnosis of celiac disease. The information cumulated up to now makes it possible to conclude that the highest diagnostic rates of celiac disease can be found in the risk groups. They include 1st and 2nd degree relatives of patients with celiac disease, patients with autoimmune disorders (typeΒ 1 diabetes mellitus, autoimmune thyroiditis); those with clinical signs of an intestinal disorder, such as chronic diarrhea, as well as patients with anemia, osteoporosis and high transaminase levels of unknown origin. According to the Finnish epidemiological study, the prevalence of celiac disease, depending on the risk group, may vary from 6.6 to 16.3%. The guidelines by the American College of Gastroenterology, British Society of Gastroenterology, North-American Society of Pediatric Gastroenterology, and the Russian Consensus on Diagnosis and Treatment of Celiac Disease in Adults and Children all recommend thorough examination of patients from the risk groups. Active diagnosis of celiac disease (screening) has been recognized as one of the approaches to primary prevention to autoimmune disorders and cancer.Π’ ΠΎΠ±Π·ΠΎΡ€Π΅ ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ свСдСния ΠΎΒ  распространСнности Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ Π²Β Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Ρ€Π΅Π³ΠΈΠΎΠ½Π°Ρ… ΠΌΠΈΡ€Π°. ΠšΠΎΠ»ΠΈΡ‡Π΅ΡΡ‚Π²ΠΎ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠ΅ΠΉ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅Ρ‚ ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ²Π°Ρ‚ΡŒΡΡ с каТдым Π³ΠΎΠ΄ΠΎΠΌ. По мнСнию Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Π°Π²Ρ‚ΠΎΡ€ΠΎΠ², это связано Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ ΡΒ ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΠ΅ΠΌ диагностики, Π½ΠΎ и с Π΄Ρ€ΡƒΠ³ΠΈΠΌΠΈ внСшними Ρ„Π°ΠΊΡ‚ΠΎΡ€Π°ΠΌΠΈ, Ρ‚Ρ€Π΅Π±ΡƒΡŽΡ‰ΠΈΠΌΠΈ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ исслСдования. Если Π²Β 80-Ρ… Π³ΠΏΡ€ΠΎΡˆΠ»ΠΎΠ³ΠΎ Π²Π΅ΠΊΠ° Ρ€Π°ΡΠΏΡ€ΠΎΡΡ‚Ρ€Π°Π½Π΅Π½Π½ΠΎΡΡ‚ΡŒ этого заболСвания составляла 1,05%, Ρ‚ΠΎ Π²Β Π½Π°Ρ‡Π°Π»Π΅ 2000-Ρ… Π΄Π°Π½Π½Ρ‹ΠΉ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒ достиг 1,99%. В частности, Π²Β Π’Π΅Π»ΠΈΠΊΠΎΠ±Ρ€ΠΈΡ‚Π°Π½ΠΈΠΈ Π²Β ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 1993 ΠΏΠΎ 2002Β Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡ‚ΡŒ возросла с 6 Π΄ΠΎ 13,3 Π½Π° 100 тыс. Π Π΅ΡˆΠ°ΡŽΡ‰ΡƒΡŽ Ρ€ΠΎΠ»ΡŒ Π²Β ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΠΈ диагностики Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ ΠΈΠ³Ρ€Π°Π΅Ρ‚ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ освСдомлСнности Π²Ρ€Π°Ρ‡Π΅ΠΉ ΠΎΒ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΈ ΠΈΒ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ эпидСмиологичСских исслСдований. НакоплСнная ΠΊΒ  настоящСму Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ информация Π΄Π°Π΅Ρ‚ основания ΡƒΡ‚Π²Π΅Ρ€ΠΆΠ΄Π°Ρ‚ΡŒ, Ρ‡Ρ‚ΠΎ наибольшая частота выявлСния Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ ΠΎΡ‚ΠΌΠ΅Ρ‡Π΅Π½Π° Π²Β Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… риска, ΠΊΒ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ относят родствСнников ΠΏΠ΅Ρ€Π²ΠΎΠΉ ΠΈΒ Π²Ρ‚ΠΎΡ€ΠΎΠΉ стСпСни родства Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠ΅ΠΉ; Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с аутоиммунной ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ (сахарный Π΄ΠΈΠ°Π±Π΅Ρ‚ 1-Π³ΠΎΒ  Ρ‚ΠΈΠΏΠ°, Π°ΡƒΡ‚ΠΎΠΈΠΌΠΌΡƒΠ½Π½Ρ‹ΠΉ Ρ‚ΠΈΡ€Π΅ΠΎΠΈΠ΄ΠΈΡ‚); Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с клиничСской симптоматикой со стороны ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ°Β  – хроничСскими поносами, Π°Β  Ρ‚Π°ΠΊΠΆΠ΅ с  Π°Π½Π΅ΠΌΠΈΠ΅ΠΉ, остСопорозом; Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с гипСртрансаминазСмиСй Π½Π΅ΡƒΡ‚ΠΎΡ‡Π½Π΅Π½Π½ΠΎΠΉ этиологии. По Π΄Π°Π½Π½Ρ‹ΠΌ эпидСмиологичСского исслСдования, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ в Ѐинляндии, частота Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ в зависимости ΠΎΡ‚ Π³Ρ€ΡƒΠΏΠΏΡ‹ риска Π²Π°Ρ€ΡŒΠΈΡ€ΡƒΠ΅Ρ‚ ΠΎΡ‚ 6,6 Π΄ΠΎ 16,3%. Π’Ρ‰Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ обслСдованиС ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΠΈΠ· Π³Ρ€ΡƒΠΏΠΏ риска прСдписываСтся рСкомСндациями АмСриканской ассоциации гастроэнтСрологов, Британского общСства гастроэнтСрологов, БСвСроамСриканского общСства пСдиатричСской гастроэнтСрологии, ВсСроссийским консСнсусом ΠΏΠΎ диагностикС ΠΈΒ  Π»Π΅Ρ‡Π΅Π½ΠΈΡŽ Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ взрослых ΠΈΒ Π΄Π΅Ρ‚Π΅ΠΉ. Активная диагностика (скрининг) Ρ†Π΅Π»ΠΈΠ°ΠΊΠΈΠΈ ΠΏΡ€ΠΈΠ·Π½Π°Π½Π° ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· способов ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½ΠΎΠΉ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ Π°ΡƒΡ‚ΠΎΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… и онкологичСских Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ
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