Sinusoidal fetal heart rate pattern

We describe 2 cases of term anemic fetuses with different sinusoidal pattern morphology, and possible mechanisms.nbspCasesmdashThe first patient noted sudden cessation of fetal movement on the day of presentation. She had a sinusoidal FHR pattern. The newborn had a hemoglobin of 3.7 g/dl, and umbilical artery pH was 7.10 and BE -7 mEq/l. The second patient noted decreased fetal movement for several days. She had a FHR pattern with absent FHR variability, and intermittent sinusoidal elements, with late decelerations. The newbornrsquos hemoglobin was 1.5 g/dl, umbilical artery pH was 7.07 and BE -10.2 mEq/l. Both cases had positive Kleihauer-Betke tests

The Last Avant-garde Phenomenon in Russian Modernization: OBERIU (A Diary of OBERIU)

OBERIU, for the Russian literature at the threshold of the 20th century when the modernization process took place in culture and the art world, is the symbol of the end of an era and actually the beginning of Stalin's dictatorship in literature by the demolition of innovative and liberal sense of art. As the last bright example of avant-garde movements in the Silver Age, OBERIU, existed for less than three years between 1927 and 1930, and left no artwork except his common manifesto. However, Kharms, better known for his miniature prose and plays than his poems, became the leading representative of the group most of whose members were young poets who came together with the aim of conveying the realities of the period with their turns of phrase which drew inspiration from their original talent. Kharms who made use of parody, absurd dialogues and elements of the grotesque, conveyed the essence of Theater of the Absurd, which was discovered late by Western European theater, in his play Yelizaveta Bam. Children’s writings, in which representatives of OBERIU took refuge as an escape, are still distinguished examples of this area. In this article, conditions under which OBERIU emerged and were tried to be erased from history, and its representatives, manifesto, principles and sense of art are studied

Cardiovascular changes during pregnancy in the ewe

In order to study maternal cardiovascular adjustments to pregnancy, serial determinations were carried out on five pregnant and lour nonpregnant ewes. Measurements were made at approximately two to three week intervals, and continued for nine weeks after delivery. Cardiac output was measured with the dye dilution technique using Evans blue dye and a continuously recording densitometer. Plasma volume was simultaneously estimated. Intra-arterial blood pressure was measured with a strain gauge transducer. All measurements were made on the sheep while they stood quietly in a stanchion, only local anesthesia being used at the sites of vessel puncture. Carotid loops were constructed to facilitate arterial catheterization. Statistical analysis was carried out by subtracting the average value of each function in each sheep for 30 days after delivery from the average value of the same function for 30 days before delivery. The differences obtained in the pregnant sheep were compared with figures similarly obtained in the nonpregnant sheep by means of the t-test. The average values of the measurements in the pregnant ewes in the last three weeks of pregnancy were as follows: a. Cardiac output, 10.3 lit/min. This was 41% greater than the average postpartum value, and the difference was statistically significant (P <0.01). Cardiac output per unit of body weight, 157 m /kg/min. This was 31% greater than the postpartum average (P <0.02). c. Heart rate, 109 beats per minute. This was 30% greater than the postpartum average (P <0.02). d. Arterial systolic blood pressure, 88 mm Hg. This was 18% less than the postpartum average (P <0.1). e. Arterial diastolic blood pressure, 74 mm Hg. This was 15% less than the postpartum average (N.S.). f. Peripheral resistance, 616 dyne sec cm⁻⁵. This was 42% less than the postpartum average (P <0.01). g. Blood volume, 4.9 liters. This was 9% greater than the postpartum average (P <0.05). h. Blood volume per unit of body weight, 74 ml/kg. This was 1% greater than the postpartum average (N.S.). i. Plasma volume, 3.4 liters. This was 10% greater than the postpartum average (P <0.05). j. Hematocrit, 31 %. This was the same as the postpartum average (N.S.). k. Body weight, 66.8 kg. This was 8% greater than the postpartum average (P <0.01). The changes accompanying pregnancy in the ewes were similar in many respects to those reported for the human. The main differences noted were the smaller increase in blood volume and absence of "anemia of pregnancy" in the sheep. The possible distribution of the increased blood flow and mechanisms involved in the circulatory adjustments to pregnancy are discussed

Comparative diffusion assay to assess efficacy of topical antimicrobial agents against Pseudomonas aeruginosa in burns care

<p>Abstract</p> <p>Background</p> <p>Severely burned patients may develop life-threatening nosocomial infections due to <it>Pseudomonas aeruginosa</it>, which can exhibit a high-level of resistance to antimicrobial drugs and has a propensity to cause nosocomial outbreaks. Antiseptic and topical antimicrobial compounds constitute major resources for burns care but in vitro testing of their activity is not performed in practice.</p> <p>Results</p> <p>In our burn unit, a <it>P. aeruginosa </it>clone multiresistant to antibiotics colonized or infected 26 patients over a 2-year period. This resident clone was characterized by PCR based on ERIC sequences. We investigated the susceptibility of the resident clone to silver sulphadiazine and to the main topical antimicrobial agents currently used in the burn unit. We proposed an optimized diffusion assay used for comparative analysis of <it>P. aeruginosa </it>strains. The resident clone displayed lower susceptibility to silver sulphadiazine and cerium silver sulphadiazine than strains unrelated to the resident clone in the unit or unrelated to the burn unit.</p> <p>Conclusions</p> <p>The diffusion assay developed herein detects differences in behaviour against antimicrobials between tested strains and a reference population. The method could be proposed for use in semi-routine practice of medical microbiology.</p