Power flow analysis with TCSC using Newton- Raphson method

In this paper, Newton Raphson power flow algorithm in matlab incorporating TCSC is presented. Overview of the different static load models for distribution system has been covered and included in N - R power flow. This paper present effect of TCSC level on transmission system voltage profile for different types of static load types , in which active and reactive power vary with its terminal voltages with as in exponential form, variation of the load voltage for different sizes of TCSC are simulated with 3 b us . It has also been observed that the proposed algorithm can be applied to larger systems and does not suffer with computational difficultie

Growth and yield responses of West Indian lemongrass (Cymbopogon citratus) to bio-inoculants under field conditions

The efficacy of commercial microbial treatment on plant growth, nutrient uptake and yield is very well recognized for medicinal plants grown in field conditions. However, the use of commercial and native microbes for Cymbopogon citratus has rarely been exploited under field conditions. Therefore, in the present study we evaluated the efficacy of single and native arbuscular mycorrhizal fungal species (AMF) to mixture of mycorrhizal fungal species plus commercial plant growth promoting bacteria (PGPR) on morphological, biochemical and traits of mycorrhizal fungi associated with C. citratus. Two native AMF species, i.e. Glomus mosseae (G) and Acaulospora laevis (A), and Pseudomonas fluorescens (P) as commercial PGPR were used in this study. Three different treatments composition of selected microbes, i.e. G, G+P, and G+A+P, were utilized along control for crop production under open field conditions in a randomized complete block design. The plantlets were grown without external application of synthetic fertilizers. The results showed that the mixture of AMF and PGPR significantly increased the survival, biomass, P content of shoot as well as root, essential oil yield, and in vitro antibacterial potential of C. citratus against Escherichia coli and Staphylococcus aureus. In general, this study provides useful insight into the mixture AMF and PGPR treatment that can be applied to improve not only the biomass, phosphorus content, antibacterial potential, and yield attributes of C. citratus under open field conditions but also to improve AMF diversity in rhizosphere soil

Microfluidic Platforms to Unravel Mysteries of Alzheimer's Disease: How Far Have We Come?

Alzheimer’s disease (AD) is a significant health concern with enormous social and economic impact globally. The gradual deterioration of cognitive functions and irreversible neuronal losses are primary features of the disease. Even after decades of research, most therapeutic options are merely symptomatic, and drugs in clinical practice present numerous side effects. Lack of effective diagnostic techniques prevents the early prognosis of disease, resulting in a gradual deterioration in the quality of life. Furthermore, the mechanism of cognitive impairment and AD pathophysiology is poorly understood. Microfluidics exploits different microscale properties of fluids to mimic environments on microfluidic chip-like devices. These miniature multichambered devices can be used to grow cells and 3D tissues in vitro, analyze cell-to-cell communication, decipher the roles of neural cells such as microglia, and gain insights into AD pathophysiology. This review focuses on the applications and impact of microfluidics on AD research. We discuss the technical challenges and possible solutions provided by this new cutting-edge technique to understand disease-associated pathways and mechanisms

Prevalence and implications of microplastics in potable water system: An update

Synthetic plastics, which are lightweight, durable, elastic, mouldable, cheap, and hydrophobic, were originally invented for human convenience. However, their non-biodegradability and continuous accumulation at an alarming rate as well as subsequent conversion into micro/nano plastic scale structures via mechanical and physio-chemical degradation pose significant threats to living beings, organisms, and the environment. Various minuscule forms of plastics detected in water, soil, and air are making their passage into living cells. High temperature and ambient humidity increase the degradation potential of plastic polymers photo-catalytically under sunlight or UV-B radiations. Microplastics (MPs) of polyethylene terephthalate, polyethylene, polystyrene, polypropylene, and polyvinyl chloride have been detected in bottled water. These microplastics are entering into the food chain cycle, causing serious harm to all living organisms. MPs entering into the food chain are usually inert in nature, possessing different sizes and shapes. Once they enter a cell or tissue, it causes mechanical damage, induces inflammation, disturbs metabolism, and even lead to necrosis. Various generation routes, types, impacts, identification, and treatment of microplastics entering the water bodies and getting associated with various pollutants are discussed in this review. It emphasizes potential detection techniques like pyrolysis, gas chromatography-mass spectrometry (GC-MS), micro-Raman spectroscopy, and fourier transform infrared spectroscopy (FT IR) spectroscopy for microplastics from water samples

Adherence to prescribed medications in patients with heart failure – insights from liquid chromatography-tandem mass spectrometry-based urine analysis

Aims: None of the existing studies on adherence have directly measured levels of medications (or their metabolites) in patients with heart failure. Methods and Results: We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4 to 6 weeks after hospitalisation with heart failure. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only 7 out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed heart failure drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients. Conclusion: Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in 1 of 5 patients evaluated 4 to 6 weeks after hospitalisation with heart failure

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Določanje ključnih akterjev za poslovno odličnost v organizacijah po procesu učinkovitega razlagalnega rangiranja (eIRP)

Flexibilities are involved in the process of decision-making. They offer much freedom of choice in terms of the selection of suitable actors who interact with the dynamic environment of the organization. This paper presents a systematic and holistic approach to ranking key actors responsible for the business excellence of an organization. The study highlights the area where the actors of the organization should focus on achieving desired business excellence. It portrays the outcome in the form that top management is the most influential actor since it is responsible for the formulation of the vision/mission of the organization along with the setting of plant quality targets, cost-saving targets, manpower planning, and policy formulation for energy-saving. Top management is followed by cross-function teams (CFTs) and the government of India (GOI) in terms of interaction with the various processes. The novelty of this case study is that it utilizes qualitative and interpretive tools for the analysis, which does not require much statistical knowledge to produce outcomes, and the results are easy to understand. The reported results are in consensus with the results reported by various studies that are conducted using quantitative tools like Analytic Hierarchy Process (AHP), Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), total interpretive structural modelling (TISM), etc. that require statistical excellence for the calculation, interpretation, and dissemination of results to the general public and shopfloor employees

Prioritizing Key Business Actions of an Indian Automobile Industry Using Efficient Interpretive Ranking Process (eIRP)

Management processes in an organization involve decision-making based on many criteria (MCDM), and in this process ranking of variables plays a vital role. This paper presents the analysis of key business issues of an Indian automotive organization using an efficient interpretive ranking (eIRP) approach. This paper integrates the Situation-Actor-Process (SAP) and Learning-Action-Performance (LAP) framework of the organization with eIRP. It evaluates the ranking of actions to be carried out in an organization with respect to performance parameters. The study highlights the area where the organization should focus on achieving desired business excellence. From the analysis, it is revealed that the top-ranked suggested action for the organization is the adoption of energy policy as a core business policy followed by technology management, maintenance management, and the use of information technology for cost management. This case study is one of the few that uses the SAP-LAP framework for ranking the actors and actions of the organization using the eIRP approach, to make MCDM an easy task