Implicit equations involving the pp-Laplace operator

In this work we study the existence of solutions $u \in W^{1,p}_0(\Omega)$ to the implicit elliptic problem $f(x, u, \nabla u, \Delta_p u)= 0$ in $\Omega$, where $\Omega$ is a bounded domain in $\mathbb R^N$, $N \ge 2$, with smooth boundary $\partial \Omega$, $1< p< +\infty$, and $f\colon \Omega \times \mathbb R \times \mathbb R^N \times \R \to \R$. We choose the particular case when the function $f$ can be expressed in the form $f(x, z, w, y)= \varphi(x, z, w)- \psi(y)$, where the function $\psi$ depends only on the $p$-Laplacian $\Delta_p u$. We also present some applications of our results.Comment: 15 pages; comments are welcom

Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease

Hirschsprung disease, or congenital megacolon, is characterized by aganglionosis of the terminal bowel, which leads to intestinal obstruction and chronic constipation. Several genes involved in the disease have been identified. In particular, haploinsufficiency of SOX10, which encodes a transcription factor, results in megacolon, often in combination with other disorders. Although Hirschsprung disease has been recognized as a neurocristopathy, the cellular mechanisms that lead to aganglionosis in affected individuals are unclear. Failure of mutant enteric progenitor cells to migrate into the gut, to survive, or to differentiate into appropriate cell types at the appropriate time and in correct numbers might contribute to the disease phenotype. In the present study, we use mice with a targeted deletion of Sox10 to study the etiology of Hirschsprung disease. We demonstrate that neural crest-derived enteric progenitors that are heterozygous for the Sox10 mutation colonize the proximal intestine and are unaffected in their survival capacity. However, unlike their wild-type counterparts, mutant enteric neural crest-derived cells are unable to maintain their progenitor state and acquire preneuronal traits, which results in a reduction of the progenitor pool size. Thus, the cells that normally colonize the hindgut are depleted in the Sox10 mutant, causing the distal bowel to become aganglioni

Financial support of the instrumental department in the public schools of Massachusetts, population of 3,000 - 11,000

Thesis (M.M.)--Boston Universit

Using haptic feedback to support cognitive mapping in mobile applications for orientation and mobility

The aim of this study, which is currently underway, is to investigate how the haptic channel can be effectively exploited in a mobile app devoted to visually impaired users, for the preliminary exploration of a complex indoor environment, such as a shopping mall

Using localisation technologies and haptic feedback for a more inclusive society

People with special needs face specific challenges in everyday activities. People with visual impairments, for example, have problems with orientation and mobility; moreover, they face serious issues when it comes to accessing information and services or perceiving the surrounding environment. Technologies such as the Internet of Things (IoT) and artificial systems can offer interesting solutions to overcome these limitations and can support users with special needs in an inclusive way

I siti UNESCO "Eredità del Mondo" - Considerazioni Geografiche

The 1972 Convention for the world cultural and natural inheritance protection is presented and commented. Subsequently, the data containing timing of adhesion and the signalling of the sites, was received from the 182 adherent countries and analysed. A most thorough analysis relates to the sites which contain heritage, adhering to the guidelines presented by UNESCO. Any historical classification is also indicated. The rigid criteria used to select locations are also indicated together with an estimate of the heritage of each country. Finally the list of sites which are currently in danger is signalled to highlight UNESCO’s attention to this area. In conclusions the aim is to indicate the level of attention each country dedicates to each site. Italy is proudly the country with the highest number of signalled sites: 40

Meccanismi dell’umorismo verbale in ‘Cuatro corazones con freno y marcha atràs’ di E. Jardiel Poncela: i giochi di parole

The aim of this paper is to examine one of the essential mechanisms in the verbal humour of Enrique Jardiel Poncela’s theatrical works, specifically focusing on one of his plays: Cuatro corazones con freno y marcha atrás (1936). In this text, the use of the pun is almost always present and it is often the basis upon which misunderstanding is produced by exploiting the language polysemous potentialities. In some cases, this strategy results as self-sufficient with respect to the action; in others, it unfolds along with the events, thus highlighting their effects